Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese Study
This prospective multicentric study aiming to determine the incidence of complications (malignant transformation, torsion or rupture) during conservative management of adnexal masses was performed in two Portuguese tertiary referral hospitals. It included ≥18-year-old, non-pregnant patients with asy...
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MDPI AG
2021-10-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/11/1992 |
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| author | Marta Espanhol Brito André Borges Sofia Rodrigues Paula Ambrósio Raquel Condeço Abílio Lacerda Maria José Bernardo Patrícia Pinto Dusan Djokovic |
| author_facet | Marta Espanhol Brito André Borges Sofia Rodrigues Paula Ambrósio Raquel Condeço Abílio Lacerda Maria José Bernardo Patrícia Pinto Dusan Djokovic |
| author_sort | Marta Espanhol Brito |
| collection | DOAJ |
| description | This prospective multicentric study aiming to determine the incidence of complications (malignant transformation, torsion or rupture) during conservative management of adnexal masses was performed in two Portuguese tertiary referral hospitals. It included ≥18-year-old, non-pregnant patients with asymptomatic adnexal masses (associated IOTA ADNEX risk of malignancy < 10%) sonographically diagnosed between January 2016 and December 2020. Conservative patient management consisted of serial clinical and ultrasound assessment up to 60 months of follow-up, spontaneous resolution of the formation or surgical excision (median follow-up: 17.8; range 9–48 months). From the 573 masses monitored (328 premenopausal and 245 postmenopausal adnexal masses), no complications were observed in 99.5%. The annual lesion growth rates and increases in morphological complexity were similar in the premenopausal and postmenopausal patients. Spontaneous resolution, evidenced in 16.4% of the patients, was more common in the premenopausal group (<i>p</i> < 0.05). Surgical intervention was performed in 18.4% of the cases; one borderline and one invasive FIGO IA stage cancer were diagnosed. There was an isolated case of ovary torsion (0.17%). These data support conservative management as a safe option for sonographically benign, stable and asymptomatic adnexal masses before and after menopause and highlight the need for expedite treatment of symptomatic or increased-morphological-complexity lesions. |
| first_indexed | 2024-03-10T05:34:22Z |
| format | Article |
| id | doaj.art-4e49cff6aa6747d1abc9329a4ea0914e |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T05:34:22Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4e49cff6aa6747d1abc9329a4ea0914e2023-11-22T23:00:46ZengMDPI AGDiagnostics2075-44182021-10-011111199210.3390/diagnostics11111992Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese StudyMarta Espanhol Brito0André Borges1Sofia Rodrigues2Paula Ambrósio3Raquel Condeço4Abílio Lacerda5Maria José Bernardo6Patrícia Pinto7Dusan Djokovic8Maternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, PortugalDepartment of Obstetrics and Gynecology, Hospital de S. Francisco Xavier, Centro Hospitalar Lisboa Ocidental (CHLO), 1449-005 Lisbon, PortugalMaternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, PortugalMaternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, PortugalMaternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, PortugalMaternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, PortugalMaternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, PortugalMaternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, PortugalMaternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário Lisboa Central (CHULC), 2890-495 Lisbon, PortugalThis prospective multicentric study aiming to determine the incidence of complications (malignant transformation, torsion or rupture) during conservative management of adnexal masses was performed in two Portuguese tertiary referral hospitals. It included ≥18-year-old, non-pregnant patients with asymptomatic adnexal masses (associated IOTA ADNEX risk of malignancy < 10%) sonographically diagnosed between January 2016 and December 2020. Conservative patient management consisted of serial clinical and ultrasound assessment up to 60 months of follow-up, spontaneous resolution of the formation or surgical excision (median follow-up: 17.8; range 9–48 months). From the 573 masses monitored (328 premenopausal and 245 postmenopausal adnexal masses), no complications were observed in 99.5%. The annual lesion growth rates and increases in morphological complexity were similar in the premenopausal and postmenopausal patients. Spontaneous resolution, evidenced in 16.4% of the patients, was more common in the premenopausal group (<i>p</i> < 0.05). Surgical intervention was performed in 18.4% of the cases; one borderline and one invasive FIGO IA stage cancer were diagnosed. There was an isolated case of ovary torsion (0.17%). These data support conservative management as a safe option for sonographically benign, stable and asymptomatic adnexal masses before and after menopause and highlight the need for expedite treatment of symptomatic or increased-morphological-complexity lesions.https://www.mdpi.com/2075-4418/11/11/1992adnexal massbenign lesionsconservative managementIOTA ADNEX modelultrasound |
| spellingShingle | Marta Espanhol Brito André Borges Sofia Rodrigues Paula Ambrósio Raquel Condeço Abílio Lacerda Maria José Bernardo Patrícia Pinto Dusan Djokovic Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese Study Diagnostics adnexal mass benign lesions conservative management IOTA ADNEX model ultrasound |
| title | Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese Study |
| title_full | Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese Study |
| title_fullStr | Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese Study |
| title_full_unstemmed | Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese Study |
| title_short | Conservative Management of Asymptomatic Adnexal Masses Classified as Benign by the IOTA ADNEX Model: A Prospective Multicenter Portuguese Study |
| title_sort | conservative management of asymptomatic adnexal masses classified as benign by the iota adnex model a prospective multicenter portuguese study |
| topic | adnexal mass benign lesions conservative management IOTA ADNEX model ultrasound |
| url | https://www.mdpi.com/2075-4418/11/11/1992 |
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