miR-124-3p sabotages lncRNA MALAT1 stability to repress chondrocyte pyroptosis and relieve cartilage injury in osteoarthritis

miR-124-3p sabotages lncRNA MALAT1 stability to repress chondrocyte pyroptosis and relieve cartilage injury in osteoarthritis

Abstract Background Osteoarthritis (OA) is a prevalent inflammatory joint disorder. microRNAs (miRNAs) are increasingly involved in OA. Aim Our study is proposed to clarify the role of miR-124-3p in chondrocyte pyroptosis and cartilage injury in OA. Methods OA mouse model was established via the tre...

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Bibliographic Details
Main Authors: Rigbat Rozi, Yubo Zhou, Kai Rong, Pingbo Chen
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Osteoarthritis
microRNA-124-3p
LncRNA MALAT1
Pyroptosis
LncRNA stability
Chondrocytes
Online Access:https://doi.org/10.1186/s13018-022-03334-8

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