How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature
Mostafa M El-Sheekh,1 Samar Sami AlKafaas,2 Hadeer A Rady,1 Bassant E Abdelmoaty,2 Heba M Bedair,1 Abdelhamid A Ahmed,3 Mohamed T El-Saadony,4 Synan F AbuQamar,5 Khaled A El-Tarabily5 1Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt; 2Molecular Cell Biology Unit, Divisio...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-11-01
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| Series: | International Journal of Nanomedicine |
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| Online Access: | https://www.dovepress.com/how-synthesis-of-algal-nanoparticles-affects-cancer-therapy--a-complet-peer-reviewed-fulltext-article-IJN |
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| author | El-Sheekh MM AlKafaas SS Rady HA Abdelmoaty BE Bedair HM Ahmed AA El-Saadony MT AbuQamar SF El-Tarabily KA |
| author_facet | El-Sheekh MM AlKafaas SS Rady HA Abdelmoaty BE Bedair HM Ahmed AA El-Saadony MT AbuQamar SF El-Tarabily KA |
| author_sort | El-Sheekh MM |
| collection | DOAJ |
| description | Mostafa M El-Sheekh,1 Samar Sami AlKafaas,2 Hadeer A Rady,1 Bassant E Abdelmoaty,2 Heba M Bedair,1 Abdelhamid A Ahmed,3 Mohamed T El-Saadony,4 Synan F AbuQamar,5 Khaled A El-Tarabily5 1Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt; 2Molecular Cell Biology Unit, Division of Biochemistry, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt; 3Plastic Surgery Department, Faculty of Medicine, Tanta University, Tanta, 31527, Egypt; 4Department of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt; 5Department of Biology, College of Science, United Arab Emirates University, Al Ain, 15551, United Arab EmiratesCorrespondence: Synan F AbuQamar; Khaled A El-Tarabily, Department of Biology, College of Science, United Arab Emirates University, Al Ain, 15551, United Arab Emirates, Tel +971 3 713 6733 ; +971 3 713 6518, Fax +971 3 713 4927, Email sabuqamar@uaeu.ac.ae; ktarabily@uaeu.ac.aeAbstract: The necessity to engineer sustainable nanomaterials for the environment and human health has recently increased. Due to their abundance, fast growth, easy cultivation, biocompatibility and richness of secondary metabolites, algae are valuable biological source for the green synthesis of nanoparticles (NPs). The aim of this review is to demonstrate the feasibility of using algal-based NPs for cancer treatment. Blue-green, brown, red and green micro- and macro-algae are the most commonly participating algae in the green synthesis of NPs. In this process, many algal bioactive compounds, such as proteins, carbohydrates, lipids, alkaloids, flavonoids and phenols, can catalyze the reduction of metal ions to NPs. In addition, many driving factors, including pH, temperature, duration, static conditions and substrate concentration, are involved to facilitate the green synthesis of algal-based NPs. Here, the biosynthesis, mechanisms and applications of algal-synthesized NPs in cancer therapy have been critically discussed. We also reviewed the effective role of algal synthesized NPs as anticancer treatment against human breast, colon and lung cancers and carcinoma.Keywords: algae, metabolites, cancer therapy, green synthesis, medical applications, nanoparticles |
| first_indexed | 2024-03-11T10:59:05Z |
| format | Article |
| id | doaj.art-4e4a5590fd754b788df66e436d1d68d6 |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-11T10:59:05Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-4e4a5590fd754b788df66e436d1d68d62023-11-12T18:07:01ZengDove Medical PressInternational Journal of Nanomedicine1178-20132023-11-01Volume 186601663888099How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the LiteratureEl-Sheekh MMAlKafaas SSRady HAAbdelmoaty BEBedair HMAhmed AAEl-Saadony MTAbuQamar SFEl-Tarabily KAMostafa M El-Sheekh,1 Samar Sami AlKafaas,2 Hadeer A Rady,1 Bassant E Abdelmoaty,2 Heba M Bedair,1 Abdelhamid A Ahmed,3 Mohamed T El-Saadony,4 Synan F AbuQamar,5 Khaled A El-Tarabily5 1Botany Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt; 2Molecular Cell Biology Unit, Division of Biochemistry, Chemistry Department, Faculty of Science, Tanta University, Tanta, 31527, Egypt; 3Plastic Surgery Department, Faculty of Medicine, Tanta University, Tanta, 31527, Egypt; 4Department of Agricultural Microbiology, Faculty of Agriculture, Zagazig University, Zagazig, 44511, Egypt; 5Department of Biology, College of Science, United Arab Emirates University, Al Ain, 15551, United Arab EmiratesCorrespondence: Synan F AbuQamar; Khaled A El-Tarabily, Department of Biology, College of Science, United Arab Emirates University, Al Ain, 15551, United Arab Emirates, Tel +971 3 713 6733 ; +971 3 713 6518, Fax +971 3 713 4927, Email sabuqamar@uaeu.ac.ae; ktarabily@uaeu.ac.aeAbstract: The necessity to engineer sustainable nanomaterials for the environment and human health has recently increased. Due to their abundance, fast growth, easy cultivation, biocompatibility and richness of secondary metabolites, algae are valuable biological source for the green synthesis of nanoparticles (NPs). The aim of this review is to demonstrate the feasibility of using algal-based NPs for cancer treatment. Blue-green, brown, red and green micro- and macro-algae are the most commonly participating algae in the green synthesis of NPs. In this process, many algal bioactive compounds, such as proteins, carbohydrates, lipids, alkaloids, flavonoids and phenols, can catalyze the reduction of metal ions to NPs. In addition, many driving factors, including pH, temperature, duration, static conditions and substrate concentration, are involved to facilitate the green synthesis of algal-based NPs. Here, the biosynthesis, mechanisms and applications of algal-synthesized NPs in cancer therapy have been critically discussed. We also reviewed the effective role of algal synthesized NPs as anticancer treatment against human breast, colon and lung cancers and carcinoma.Keywords: algae, metabolites, cancer therapy, green synthesis, medical applications, nanoparticleshttps://www.dovepress.com/how-synthesis-of-algal-nanoparticles-affects-cancer-therapy--a-complet-peer-reviewed-fulltext-article-IJNalgaemetabolitescancer therapygreen synthesismedical applicationsnanoparticles |
| spellingShingle | El-Sheekh MM AlKafaas SS Rady HA Abdelmoaty BE Bedair HM Ahmed AA El-Saadony MT AbuQamar SF El-Tarabily KA How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature International Journal of Nanomedicine algae metabolites cancer therapy green synthesis medical applications nanoparticles |
| title | How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature |
| title_full | How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature |
| title_fullStr | How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature |
| title_full_unstemmed | How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature |
| title_short | How Synthesis of Algal Nanoparticles Affects Cancer Therapy? – A Complete Review of the Literature |
| title_sort | how synthesis of algal nanoparticles affects cancer therapy ndash a complete review of the literature |
| topic | algae metabolites cancer therapy green synthesis medical applications nanoparticles |
| url | https://www.dovepress.com/how-synthesis-of-algal-nanoparticles-affects-cancer-therapy--a-complet-peer-reviewed-fulltext-article-IJN |
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