Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain
Abstract Background The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can...
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | International Journal of Behavioral Nutrition and Physical Activity |
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| Online Access: | https://doi.org/10.1186/s12966-021-01219-3 |
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| author | Mario Delgado-Velandia Vannina Gonzalez-Marrachelli Arce Domingo-Relloso Marta Galvez-Fernandez Maria Grau-Perez Pablo Olmedo Iñaki Galan Fernando Rodriguez-Artalejo Nuria Amigo Laisa Briongos-Figuero Josep Redon Juan Carlos Martin-Escudero Daniel Monleon-Salvado Maria Tellez-Plaza Mercedes Sotos-Prieto |
| author_facet | Mario Delgado-Velandia Vannina Gonzalez-Marrachelli Arce Domingo-Relloso Marta Galvez-Fernandez Maria Grau-Perez Pablo Olmedo Iñaki Galan Fernando Rodriguez-Artalejo Nuria Amigo Laisa Briongos-Figuero Josep Redon Juan Carlos Martin-Escudero Daniel Monleon-Salvado Maria Tellez-Plaza Mercedes Sotos-Prieto |
| author_sort | Mario Delgado-Velandia |
| collection | DOAJ |
| description | Abstract Background The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explain the prospective association between healthy lifestyle and incident type 2 diabetes. Methods A Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption and BMI) was estimated in 1016 Hortega Study participants, who had targeted plasma metabolomic determinations at baseline examination in 2001–2003, and were followed-up to 2015 to ascertain incident type 2 diabetes. Results The HLS was cross-sectionally associated with 32 (out of 49) plasma metabolites (2.5% false discovery rate). In the subset of 830 participants without prevalent type 2 diabetes, the rate ratio (RR) and rate difference (RD) of incident type 2 diabetes (n cases = 51) per one-point increase in HLS was, respectively, 0.69 (95% CI, 0.51, 0.93), and − 8.23 (95% CI, − 16.34, − 0.13)/10,000 person-years. In single-metabolite models, most of the HLS-related metabolites were prospectively associated with incident type 2 diabetes. In probit Bayesian Kernel Machine Regression, these prospective associations were mostly driven by medium HDL particle concentration and phenylpropionate, followed by small LDL particle concentration, which jointly accounted for ~ 50% of the HLS-related decrease in incident type 2 diabetes. Conclusions The HLS showed a strong inverse association with incident type 2 diabetes, which was largely explained by plasma metabolites measured years before the clinical diagnosis. |
| first_indexed | 2024-12-20T07:01:34Z |
| format | Article |
| id | doaj.art-4e51b3822fa24408b649cedfdde4bfab |
| institution | Directory Open Access Journal |
| issn | 1479-5868 |
| language | English |
| last_indexed | 2024-12-20T07:01:34Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | International Journal of Behavioral Nutrition and Physical Activity |
| spelling | doaj.art-4e51b3822fa24408b649cedfdde4bfab2022-12-21T19:49:11ZengBMCInternational Journal of Behavioral Nutrition and Physical Activity1479-58682022-01-0119111310.1186/s12966-021-01219-3Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from SpainMario Delgado-Velandia0Vannina Gonzalez-Marrachelli1Arce Domingo-Relloso2Marta Galvez-Fernandez3Maria Grau-Perez4Pablo Olmedo5Iñaki Galan6Fernando Rodriguez-Artalejo7Nuria Amigo8Laisa Briongos-Figuero9Josep Redon10Juan Carlos Martin-Escudero11Daniel Monleon-Salvado12Maria Tellez-Plaza13Mercedes Sotos-Prieto14Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autonoma de Madrid; Instituto de Investigacion Sanitaria Hospital Universitario La Paz (IdiPaz)Department of Physiology, School of Medicine, University of ValenciaIntegrative Epidemiology Group, Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health InstitutesDepartment of Preventive Medicine and Public Health. School of Medicine, Universidad Autonoma de Madrid; Instituto de Investigacion Sanitaria Hospital Universitario La Paz (IdiPaz)Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autonoma de Madrid; Instituto de Investigacion Sanitaria Hospital Universitario La Paz (IdiPaz)Institute for Biomedical Research Hospital Clinic de Valencia INCLIVADepartment of Preventive Medicine and Public Health. School of Medicine, Universidad Autonoma de Madrid; Instituto de Investigacion Sanitaria Hospital Universitario La Paz (IdiPaz)Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autonoma de Madrid; Instituto de Investigacion Sanitaria Hospital Universitario La Paz (IdiPaz)Biosfer Teslab, Av. UniversitatDepartment of Internal Medicine, University Hospital Rio HortegaInstitute for Biomedical Research Hospital Clinic de Valencia INCLIVADepartment of Internal Medicine, University Hospital Rio HortegaDepartment of Physiology, School of Medicine, University of ValenciaDepartment of Preventive Medicine and Public Health. School of Medicine, Universidad Autonoma de Madrid; Instituto de Investigacion Sanitaria Hospital Universitario La Paz (IdiPaz)Department of Preventive Medicine and Public Health. School of Medicine, Universidad Autonoma de Madrid; Instituto de Investigacion Sanitaria Hospital Universitario La Paz (IdiPaz)Abstract Background The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explain the prospective association between healthy lifestyle and incident type 2 diabetes. Methods A Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption and BMI) was estimated in 1016 Hortega Study participants, who had targeted plasma metabolomic determinations at baseline examination in 2001–2003, and were followed-up to 2015 to ascertain incident type 2 diabetes. Results The HLS was cross-sectionally associated with 32 (out of 49) plasma metabolites (2.5% false discovery rate). In the subset of 830 participants without prevalent type 2 diabetes, the rate ratio (RR) and rate difference (RD) of incident type 2 diabetes (n cases = 51) per one-point increase in HLS was, respectively, 0.69 (95% CI, 0.51, 0.93), and − 8.23 (95% CI, − 16.34, − 0.13)/10,000 person-years. In single-metabolite models, most of the HLS-related metabolites were prospectively associated with incident type 2 diabetes. In probit Bayesian Kernel Machine Regression, these prospective associations were mostly driven by medium HDL particle concentration and phenylpropionate, followed by small LDL particle concentration, which jointly accounted for ~ 50% of the HLS-related decrease in incident type 2 diabetes. Conclusions The HLS showed a strong inverse association with incident type 2 diabetes, which was largely explained by plasma metabolites measured years before the clinical diagnosis.https://doi.org/10.1186/s12966-021-01219-3Cohort studyHealthy lifestyleMetabolomicsSpanish populationType 2 diabetes |
| spellingShingle | Mario Delgado-Velandia Vannina Gonzalez-Marrachelli Arce Domingo-Relloso Marta Galvez-Fernandez Maria Grau-Perez Pablo Olmedo Iñaki Galan Fernando Rodriguez-Artalejo Nuria Amigo Laisa Briongos-Figuero Josep Redon Juan Carlos Martin-Escudero Daniel Monleon-Salvado Maria Tellez-Plaza Mercedes Sotos-Prieto Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain International Journal of Behavioral Nutrition and Physical Activity Cohort study Healthy lifestyle Metabolomics Spanish population Type 2 diabetes |
| title | Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain |
| title_full | Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain |
| title_fullStr | Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain |
| title_full_unstemmed | Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain |
| title_short | Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain |
| title_sort | healthy lifestyle metabolomics and incident type 2 diabetes in a population based cohort from spain |
| topic | Cohort study Healthy lifestyle Metabolomics Spanish population Type 2 diabetes |
| url | https://doi.org/10.1186/s12966-021-01219-3 |
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