Novel Gene Regulation in Normal and Abnormal Spermatogenesis
Spermatogenesis is a complex and dynamic process which is precisely controlledby genetic and epigenetic factors. With the development of new technologies (e.g., single-cell RNA sequencing), increasingly more regulatory genes related to spermatogenesis have been identified. In this review, we address...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/10/3/666 |
| _version_ | 1797541037051215872 |
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| author | Li Du Wei Chen Zixin Cheng Si Wu Jian He Lu Han Zuping He Weibing Qin |
| author_facet | Li Du Wei Chen Zixin Cheng Si Wu Jian He Lu Han Zuping He Weibing Qin |
| author_sort | Li Du |
| collection | DOAJ |
| description | Spermatogenesis is a complex and dynamic process which is precisely controlledby genetic and epigenetic factors. With the development of new technologies (e.g., single-cell RNA sequencing), increasingly more regulatory genes related to spermatogenesis have been identified. In this review, we address the roles and mechanisms of novel genes in regulating the normal and abnormal spermatogenesis. Specifically, we discussed the functions and signaling pathways of key new genes in mediating the proliferation, differentiation, and apoptosis of rodent and human spermatogonial stem cells (SSCs), as well as in controlling the meiosis of spermatocytes and other germ cells. Additionally, we summarized the gene regulation in the abnormal testicular microenvironment or the niche by Sertoli cells, peritubular myoid cells, and Leydig cells. Finally, we pointed out the future directions for investigating the molecular mechanisms underlying human spermatogenesis. This review could offer novel insights into genetic regulation in the normal and abnormal spermatogenesis, and it provides new molecular targets for gene therapy of male infertility. |
| first_indexed | 2024-03-10T13:09:34Z |
| format | Article |
| id | doaj.art-4e51dd174c0d4d21adf8e33facb8cacb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T13:09:34Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4e51dd174c0d4d21adf8e33facb8cacb2023-11-21T10:51:06ZengMDPI AGCells2073-44092021-03-0110366610.3390/cells10030666Novel Gene Regulation in Normal and Abnormal SpermatogenesisLi Du0Wei Chen1Zixin Cheng2Si Wu3Jian He4Lu Han5Zuping He6Weibing Qin7The Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Hunan Normal University, 371 Tongzipo Road, Changsha 410013, ChinaThe Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Hunan Normal University, 371 Tongzipo Road, Changsha 410013, ChinaThe Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Hunan Normal University, 371 Tongzipo Road, Changsha 410013, ChinaThe Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Hunan Normal University, 371 Tongzipo Road, Changsha 410013, ChinaThe Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Hunan Normal University, 371 Tongzipo Road, Changsha 410013, ChinaThe NHC Key Laboratory of Male Reproduction and Genetics, Family Planning Research Institute of Guangdong Province, Guangzhou 510600, ChinaThe Key Laboratory of Model Animals and Stem Cell Biology in Hunan Province, School of Medicine, Hunan Normal University, 371 Tongzipo Road, Changsha 410013, ChinaThe NHC Key Laboratory of Male Reproduction and Genetics, Family Planning Research Institute of Guangdong Province, Guangzhou 510600, ChinaSpermatogenesis is a complex and dynamic process which is precisely controlledby genetic and epigenetic factors. With the development of new technologies (e.g., single-cell RNA sequencing), increasingly more regulatory genes related to spermatogenesis have been identified. In this review, we address the roles and mechanisms of novel genes in regulating the normal and abnormal spermatogenesis. Specifically, we discussed the functions and signaling pathways of key new genes in mediating the proliferation, differentiation, and apoptosis of rodent and human spermatogonial stem cells (SSCs), as well as in controlling the meiosis of spermatocytes and other germ cells. Additionally, we summarized the gene regulation in the abnormal testicular microenvironment or the niche by Sertoli cells, peritubular myoid cells, and Leydig cells. Finally, we pointed out the future directions for investigating the molecular mechanisms underlying human spermatogenesis. This review could offer novel insights into genetic regulation in the normal and abnormal spermatogenesis, and it provides new molecular targets for gene therapy of male infertility.https://www.mdpi.com/2073-4409/10/3/666genesregulationspermatogenesisfunctions and mechanismsmale infertility |
| spellingShingle | Li Du Wei Chen Zixin Cheng Si Wu Jian He Lu Han Zuping He Weibing Qin Novel Gene Regulation in Normal and Abnormal Spermatogenesis Cells genes regulation spermatogenesis functions and mechanisms male infertility |
| title | Novel Gene Regulation in Normal and Abnormal Spermatogenesis |
| title_full | Novel Gene Regulation in Normal and Abnormal Spermatogenesis |
| title_fullStr | Novel Gene Regulation in Normal and Abnormal Spermatogenesis |
| title_full_unstemmed | Novel Gene Regulation in Normal and Abnormal Spermatogenesis |
| title_short | Novel Gene Regulation in Normal and Abnormal Spermatogenesis |
| title_sort | novel gene regulation in normal and abnormal spermatogenesis |
| topic | genes regulation spermatogenesis functions and mechanisms male infertility |
| url | https://www.mdpi.com/2073-4409/10/3/666 |
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