Impact of Baseline and Trajectory of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus
Background and AimsThis study aimed to evaluate the association of the triglyceride-glucose (TyG) index with the cardiovascular incidence in patients with type 2 diabetes mellitus (T2DM).Methods and ResultsSecondary analysis in patients with long-lasting T2DM from the Action to Control Cardiovascula...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.858209/full |
| _version_ | 1811271656910356480 |
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| author | Shi Tai Liyao Fu Ningjie Zhang Ying Zhou Zhenhua Xing Yongjun Wang |
| author_facet | Shi Tai Liyao Fu Ningjie Zhang Ying Zhou Zhenhua Xing Yongjun Wang |
| author_sort | Shi Tai |
| collection | DOAJ |
| description | Background and AimsThis study aimed to evaluate the association of the triglyceride-glucose (TyG) index with the cardiovascular incidence in patients with type 2 diabetes mellitus (T2DM).Methods and ResultsSecondary analysis in patients with long-lasting T2DM from the Action to Control Cardiovascular Risk in Diabetes study was performed. The primary outcome was the first occurrence of major adverse cardiovascular events (MACEs). The association between the baseline and trajectories of the TyG index and MACEs was evaluated by Cox proportional hazards regression analysis. During a median follow-up period of 8.8 years, 1,815 (17.8%) patients developed MACEs. After traditional cardiovascular risk factor adjustments, each 1-standard deviation increase in the TyG index was associated with a 19.00% higher MACE risk, similar to that in the TyG index quartile characterization. Four distinct trajectories of TyG indexes were identified: low (16.17%), moderate (40.01%), high (34.60%), and very high (9.30%). In multivariate analysis, high and very high TyG index trajectories showed a greater risk of future MACE incidence than the low TyG index trajectory. A similar association was observed between the TyG index and the occurrence of coronary heart disease.ConclusionsThe baseline and trajectories of the TyG index were significantly associated with the occurrence of MACEs in patients with T2DM.Clinical Trial Registrationhttp://www.clinicaltrials.gov. Unique identifier: NCT00000620. |
| first_indexed | 2024-04-12T22:23:54Z |
| format | Article |
| id | doaj.art-4e533e3f1e9242e698ebbaae92654353 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T22:23:54Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4e533e3f1e9242e698ebbaae926543532022-12-22T03:14:13ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-03-011310.3389/fendo.2022.858209858209Impact of Baseline and Trajectory of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients With Type 2 Diabetes MellitusShi Tai0Liyao Fu1Ningjie Zhang2Ying Zhou3Zhenhua Xing4Yongjun Wang5Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, ChinaBackground and AimsThis study aimed to evaluate the association of the triglyceride-glucose (TyG) index with the cardiovascular incidence in patients with type 2 diabetes mellitus (T2DM).Methods and ResultsSecondary analysis in patients with long-lasting T2DM from the Action to Control Cardiovascular Risk in Diabetes study was performed. The primary outcome was the first occurrence of major adverse cardiovascular events (MACEs). The association between the baseline and trajectories of the TyG index and MACEs was evaluated by Cox proportional hazards regression analysis. During a median follow-up period of 8.8 years, 1,815 (17.8%) patients developed MACEs. After traditional cardiovascular risk factor adjustments, each 1-standard deviation increase in the TyG index was associated with a 19.00% higher MACE risk, similar to that in the TyG index quartile characterization. Four distinct trajectories of TyG indexes were identified: low (16.17%), moderate (40.01%), high (34.60%), and very high (9.30%). In multivariate analysis, high and very high TyG index trajectories showed a greater risk of future MACE incidence than the low TyG index trajectory. A similar association was observed between the TyG index and the occurrence of coronary heart disease.ConclusionsThe baseline and trajectories of the TyG index were significantly associated with the occurrence of MACEs in patients with T2DM.Clinical Trial Registrationhttp://www.clinicaltrials.gov. Unique identifier: NCT00000620.https://www.frontiersin.org/articles/10.3389/fendo.2022.858209/fulltriglyceride-glucose indexcardiovascular diseasetype 2 diabetes mellitusrisk factorsinsulin resistance glycated hemoglobin |
| spellingShingle | Shi Tai Liyao Fu Ningjie Zhang Ying Zhou Zhenhua Xing Yongjun Wang Impact of Baseline and Trajectory of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus Frontiers in Endocrinology triglyceride-glucose index cardiovascular disease type 2 diabetes mellitus risk factors insulin resistance glycated hemoglobin |
| title | Impact of Baseline and Trajectory of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus |
| title_full | Impact of Baseline and Trajectory of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus |
| title_fullStr | Impact of Baseline and Trajectory of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus |
| title_full_unstemmed | Impact of Baseline and Trajectory of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus |
| title_short | Impact of Baseline and Trajectory of Triglyceride-Glucose Index on Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus |
| title_sort | impact of baseline and trajectory of triglyceride glucose index on cardiovascular outcomes in patients with type 2 diabetes mellitus |
| topic | triglyceride-glucose index cardiovascular disease type 2 diabetes mellitus risk factors insulin resistance glycated hemoglobin |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.858209/full |
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