Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior
<p>Abstract</p> <p>Background</p> <p>Sleep homeostasis is characterized by a positive correlation between sleep length and intensity with the duration of the prior waking period. A causal role for brain-derived neurotrophic factor (BDNF) in sleep homeostasis has been su...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-03-01
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| Series: | Molecular Brain |
| Online Access: | http://www.molecularbrain.com/content/4/1/11 |
| _version_ | 1818351537057955840 |
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| author | Martinowich Keri Schloesser Robert J Jimenez Dennisse V Weinberger Daniel R Lu Bai |
| author_facet | Martinowich Keri Schloesser Robert J Jimenez Dennisse V Weinberger Daniel R Lu Bai |
| author_sort | Martinowich Keri |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Sleep homeostasis is characterized by a positive correlation between sleep length and intensity with the duration of the prior waking period. A causal role for brain-derived neurotrophic factor (BDNF) in sleep homeostasis has been suggested, but the underlying mechanisms remain unclear. Cortistatin, a neuropeptide expressed primarily in a subset of cortical GABAergic interneurons, is another molecule implicated in sleep homeostasis.</p> <p>Results</p> <p>We confirmed that sleep deprivation leads to an increase in cortical cortistatin mRNA expression. Disruption of activity-dependent BDNF expression in a genetically modified mouse line impairs both baseline levels of cortistatin mRNA as well as its levels following sleep deprivation. Disruption of activity-dependent BDNF also leads to a decrease in sleep time during the active (dark) phase.</p> <p>Conclusion</p> <p>Our studies suggest that regulation of cortistatin-expressing interneurons by activity-dependent BDNF expression may contribute to regulation of sleep behavior.</p> |
| first_indexed | 2024-12-13T18:39:19Z |
| format | Article |
| id | doaj.art-4e5537555092432d84ef6462c519716c |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-13T18:39:19Z |
| publishDate | 2011-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-4e5537555092432d84ef6462c519716c2022-12-21T23:35:16ZengBMCMolecular Brain1756-66062011-03-01411110.1186/1756-6606-4-11Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behaviorMartinowich KeriSchloesser Robert JJimenez Dennisse VWeinberger Daniel RLu Bai<p>Abstract</p> <p>Background</p> <p>Sleep homeostasis is characterized by a positive correlation between sleep length and intensity with the duration of the prior waking period. A causal role for brain-derived neurotrophic factor (BDNF) in sleep homeostasis has been suggested, but the underlying mechanisms remain unclear. Cortistatin, a neuropeptide expressed primarily in a subset of cortical GABAergic interneurons, is another molecule implicated in sleep homeostasis.</p> <p>Results</p> <p>We confirmed that sleep deprivation leads to an increase in cortical cortistatin mRNA expression. Disruption of activity-dependent BDNF expression in a genetically modified mouse line impairs both baseline levels of cortistatin mRNA as well as its levels following sleep deprivation. Disruption of activity-dependent BDNF also leads to a decrease in sleep time during the active (dark) phase.</p> <p>Conclusion</p> <p>Our studies suggest that regulation of cortistatin-expressing interneurons by activity-dependent BDNF expression may contribute to regulation of sleep behavior.</p>http://www.molecularbrain.com/content/4/1/11 |
| spellingShingle | Martinowich Keri Schloesser Robert J Jimenez Dennisse V Weinberger Daniel R Lu Bai Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior Molecular Brain |
| title | Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior |
| title_full | Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior |
| title_fullStr | Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior |
| title_full_unstemmed | Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior |
| title_short | Activity-dependent brain-derived neurotrophic factor expression regulates cortistatin-interneurons and sleep behavior |
| title_sort | activity dependent brain derived neurotrophic factor expression regulates cortistatin interneurons and sleep behavior |
| url | http://www.molecularbrain.com/content/4/1/11 |
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