A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders
Cognitive impairments are core features of established schizophrenia spectrum disorders (SSD). However, it remains unclear whether specific cognitive functions are differentially impaired pre-onset and at what age these impairments can be detected. The purpose of this review was to elucidate these i...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-06-01
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| Series: | Schizophrenia Research: Cognition |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2215001322000117 |
| _version_ | 1818288653613400064 |
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| author | Caroline Ranem Mohn-Haugen Christine Mohn Frank Larøi Charlotte M. Teigset Merete Glenne Øie Bjørn Rishovd Rund |
| author_facet | Caroline Ranem Mohn-Haugen Christine Mohn Frank Larøi Charlotte M. Teigset Merete Glenne Øie Bjørn Rishovd Rund |
| author_sort | Caroline Ranem Mohn-Haugen |
| collection | DOAJ |
| description | Cognitive impairments are core features of established schizophrenia spectrum disorders (SSD). However, it remains unclear whether specific cognitive functions are differentially impaired pre-onset and at what age these impairments can be detected. The purpose of this review was to elucidate these issues through a systematic summary of results from longitudinal studies investigating impairment in specific cognitive domains as antecedents of SSD.Relevant studies were identified by electronic and manual literature searches and included any original study of cognitive domains any time pre-onset of SSDs that included a control group. Effect sizes were calculated by domain for studies comparing high-risk participants who developed SSD with those who did not.The strongest evidence for impairment pre-onset was for mental processing speed, verbal learning and memory, executive function, and social cognition. Some verbal impairments, like language abilities at age 3 and verbal learning and memory at age 7, may develop as static deficits. Conversely, some non-verbal impairments, like mental processing speed, visuospatial abilities, and visual working memory manifest as developmental lag and become significant later in life. Most effect sizes were small to moderate, except for verbal fluency (d′ = 0,85), implying this impairment as central in high-risk participants who develop SSD.The present review documents extensive cognitive impairments pre-onset of SSD, and that these impairments start early in life, in line with the neurodevelopmental hypothesis of schizophrenia. Increased knowledge about cognitive impairments preonset can provide a better basis for understanding the complex pathogenesis of SSD as well as informing cognitive remediation programs. |
| first_indexed | 2024-12-13T01:59:48Z |
| format | Article |
| id | doaj.art-4e5540da051945acb29ca653e179b75b |
| institution | Directory Open Access Journal |
| issn | 2215-0013 |
| language | English |
| last_indexed | 2024-12-13T01:59:48Z |
| publishDate | 2022-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Schizophrenia Research: Cognition |
| spelling | doaj.art-4e5540da051945acb29ca653e179b75b2022-12-22T00:03:18ZengElsevierSchizophrenia Research: Cognition2215-00132022-06-0128100246A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disordersCaroline Ranem Mohn-Haugen0Christine Mohn1Frank Larøi2Charlotte M. Teigset3Merete Glenne Øie4Bjørn Rishovd Rund5Research Department, Vestre Viken Hospital Trust, 3004 Drammen, Norway; Department of Psychology, P. O. box 1094, Blindern, University of Oslo, 0317 Oslo, Norway; Corresponding author at: Department of Psychology, P.O. box 0317, Blindern, Oslo, Norway.Norment Centre, Institute of Clinical Medicine, University of Oslo, P.O. box 4956, Nydalen, 0424 Oslo, NorwayDepartment of Psychology, P. O. box 1094, Blindern, University of Oslo, 0317 Oslo, Norway; Psychology and Neuroscience of Cognition Research Unit, University of Liège, B-4000, BelgiumResearch Department, Vestre Viken Hospital Trust, 3004 Drammen, NorwayDepartment of Psychology, P. O. box 1094, Blindern, University of Oslo, 0317 Oslo, NorwayResearch Department, Vestre Viken Hospital Trust, 3004 Drammen, Norway; Department of Psychology, P. O. box 1094, Blindern, University of Oslo, 0317 Oslo, NorwayCognitive impairments are core features of established schizophrenia spectrum disorders (SSD). However, it remains unclear whether specific cognitive functions are differentially impaired pre-onset and at what age these impairments can be detected. The purpose of this review was to elucidate these issues through a systematic summary of results from longitudinal studies investigating impairment in specific cognitive domains as antecedents of SSD.Relevant studies were identified by electronic and manual literature searches and included any original study of cognitive domains any time pre-onset of SSDs that included a control group. Effect sizes were calculated by domain for studies comparing high-risk participants who developed SSD with those who did not.The strongest evidence for impairment pre-onset was for mental processing speed, verbal learning and memory, executive function, and social cognition. Some verbal impairments, like language abilities at age 3 and verbal learning and memory at age 7, may develop as static deficits. Conversely, some non-verbal impairments, like mental processing speed, visuospatial abilities, and visual working memory manifest as developmental lag and become significant later in life. Most effect sizes were small to moderate, except for verbal fluency (d′ = 0,85), implying this impairment as central in high-risk participants who develop SSD.The present review documents extensive cognitive impairments pre-onset of SSD, and that these impairments start early in life, in line with the neurodevelopmental hypothesis of schizophrenia. Increased knowledge about cognitive impairments preonset can provide a better basis for understanding the complex pathogenesis of SSD as well as informing cognitive remediation programs.http://www.sciencedirect.com/science/article/pii/S2215001322000117Schizophrenia spectrum disordersPremorbid cognitive functionOnset of cognitive impairmentSchizophreniaCognition |
| spellingShingle | Caroline Ranem Mohn-Haugen Christine Mohn Frank Larøi Charlotte M. Teigset Merete Glenne Øie Bjørn Rishovd Rund A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders Schizophrenia Research: Cognition Schizophrenia spectrum disorders Premorbid cognitive function Onset of cognitive impairment Schizophrenia Cognition |
| title | A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders |
| title_full | A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders |
| title_fullStr | A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders |
| title_full_unstemmed | A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders |
| title_short | A systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders |
| title_sort | systematic review of premorbid cognitive functioning and its timing of onset in schizophrenia spectrum disorders |
| topic | Schizophrenia spectrum disorders Premorbid cognitive function Onset of cognitive impairment Schizophrenia Cognition |
| url | http://www.sciencedirect.com/science/article/pii/S2215001322000117 |
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