Engineering Rational SERS Nanotags for Parallel Detection of Multiple Cancer Circulating Biomarkers
Precision cancer medicine necessitates a personalized treatment plan for each individual patient. Given cancer’s heterogeneity and dynamic nature, the plot of patient-specific signatures composed of multiple cancer circulating biomarkers is useful to reveal the complete tumor landscape for guiding p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-02-01
|
| Series: | Chemosensors |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9040/11/2/110 |
| _version_ | 1827758097639145472 |
|---|---|
| author | Zhipeng Zhang Rui Guan Junrong Li Yao Sun |
| author_facet | Zhipeng Zhang Rui Guan Junrong Li Yao Sun |
| author_sort | Zhipeng Zhang |
| collection | DOAJ |
| description | Precision cancer medicine necessitates a personalized treatment plan for each individual patient. Given cancer’s heterogeneity and dynamic nature, the plot of patient-specific signatures composed of multiple cancer circulating biomarkers is useful to reveal the complete tumor landscape for guiding precision medicine. As an emerging new technology, surface-enhanced Raman scattering (SERS) shows the intrinsic advantage of performing multiplexed detection with the extremely narrow Raman spectral line widths. In this review, we first discuss the design principle of SERS nanotags to enable the detection of multiple circulating biomarkers, highlighting the important roles of plasmonic nanostructures and triple bond-modulated Raman reporters. Following this, we detail the use of isotropic and anisotropic nanostructures as SERS enhancement substrates for amplifying Raman signals in multi-biomarker detection. Furthermore, we present the triple bond-modulated molecules as Raman reporters in SERS nanotags to expand the multiplexing capability for biomarker measurements. Finally, we offer critical insights into the challenges and perspectives of SERS nanotags for cancer diagnosis, particularly from the aspect of future clinical transition. It is expected that this review can facilitate the design of more functional SERS nanotags with high sensitivity and multiplexing capability to assist early and accurate cancer screening. We also believe our review will be of interest in the fields of molecular imaging, biomedicine, and analytical chemistry. |
| first_indexed | 2024-03-11T08:59:51Z |
| format | Article |
| id | doaj.art-4e5591b3a0c64e30b285796f3f14fa75 |
| institution | Directory Open Access Journal |
| issn | 2227-9040 |
| language | English |
| last_indexed | 2024-03-11T08:59:51Z |
| publishDate | 2023-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Chemosensors |
| spelling | doaj.art-4e5591b3a0c64e30b285796f3f14fa752023-11-16T19:46:25ZengMDPI AGChemosensors2227-90402023-02-0111211010.3390/chemosensors11020110Engineering Rational SERS Nanotags for Parallel Detection of Multiple Cancer Circulating BiomarkersZhipeng Zhang0Rui Guan1Junrong Li2Yao Sun3Xianning Medical College, College of Pharmacy, Hubei University of Science & Technology, Xianning 437100, ChinaKey Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430072, ChinaKey Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430072, ChinaKey Laboratory of Pesticide and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430072, ChinaPrecision cancer medicine necessitates a personalized treatment plan for each individual patient. Given cancer’s heterogeneity and dynamic nature, the plot of patient-specific signatures composed of multiple cancer circulating biomarkers is useful to reveal the complete tumor landscape for guiding precision medicine. As an emerging new technology, surface-enhanced Raman scattering (SERS) shows the intrinsic advantage of performing multiplexed detection with the extremely narrow Raman spectral line widths. In this review, we first discuss the design principle of SERS nanotags to enable the detection of multiple circulating biomarkers, highlighting the important roles of plasmonic nanostructures and triple bond-modulated Raman reporters. Following this, we detail the use of isotropic and anisotropic nanostructures as SERS enhancement substrates for amplifying Raman signals in multi-biomarker detection. Furthermore, we present the triple bond-modulated molecules as Raman reporters in SERS nanotags to expand the multiplexing capability for biomarker measurements. Finally, we offer critical insights into the challenges and perspectives of SERS nanotags for cancer diagnosis, particularly from the aspect of future clinical transition. It is expected that this review can facilitate the design of more functional SERS nanotags with high sensitivity and multiplexing capability to assist early and accurate cancer screening. We also believe our review will be of interest in the fields of molecular imaging, biomedicine, and analytical chemistry.https://www.mdpi.com/2227-9040/11/2/110SERSRamannanotagescancer diagnosis |
| spellingShingle | Zhipeng Zhang Rui Guan Junrong Li Yao Sun Engineering Rational SERS Nanotags for Parallel Detection of Multiple Cancer Circulating Biomarkers Chemosensors SERS Raman nanotages cancer diagnosis |
| title | Engineering Rational SERS Nanotags for Parallel Detection of Multiple Cancer Circulating Biomarkers |
| title_full | Engineering Rational SERS Nanotags for Parallel Detection of Multiple Cancer Circulating Biomarkers |
| title_fullStr | Engineering Rational SERS Nanotags for Parallel Detection of Multiple Cancer Circulating Biomarkers |
| title_full_unstemmed | Engineering Rational SERS Nanotags for Parallel Detection of Multiple Cancer Circulating Biomarkers |
| title_short | Engineering Rational SERS Nanotags for Parallel Detection of Multiple Cancer Circulating Biomarkers |
| title_sort | engineering rational sers nanotags for parallel detection of multiple cancer circulating biomarkers |
| topic | SERS Raman nanotages cancer diagnosis |
| url | https://www.mdpi.com/2227-9040/11/2/110 |
| work_keys_str_mv | AT zhipengzhang engineeringrationalsersnanotagsforparalleldetectionofmultiplecancercirculatingbiomarkers AT ruiguan engineeringrationalsersnanotagsforparalleldetectionofmultiplecancercirculatingbiomarkers AT junrongli engineeringrationalsersnanotagsforparalleldetectionofmultiplecancercirculatingbiomarkers AT yaosun engineeringrationalsersnanotagsforparalleldetectionofmultiplecancercirculatingbiomarkers |