Association between serum osteocalcin level and blood pressure in a Chinese population
Purpose: This observational study investigated the association between serum osteocalcin level and blood pressure in a Chinese population. Materials and methods: A total of 2241 subjects (909 men and 1,332 women; age, 24–78 years) from Shanghai communities were recruited. Subjects were divided into...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2018-03-01
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| Series: | Blood Pressure |
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| Online Access: | http://dx.doi.org/10.1080/08037051.2017.1408005 |
| _version_ | 1797685071491104768 |
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| author | Yiting Xu Xiaojing Ma Qin Xiong Xiang Hu Xueli Zhang Yeqing Yuan Yuqian Bao |
| author_facet | Yiting Xu Xiaojing Ma Qin Xiong Xiang Hu Xueli Zhang Yeqing Yuan Yuqian Bao |
| author_sort | Yiting Xu |
| collection | DOAJ |
| description | Purpose: This observational study investigated the association between serum osteocalcin level and blood pressure in a Chinese population. Materials and methods: A total of 2241 subjects (909 men and 1,332 women; age, 24–78 years) from Shanghai communities were recruited. Subjects were divided into non-hypertensive and hypertensive groups according to diagnosis of hypertension based on the 1999 World Health Organization-International Society of Hypertension Guidelines. Serum osteocalcin levels were measured using an electrochemiluminescence immunoassay. Results: Men in the hypertensive group showed lower serum osteocalcin level compared with those in the non-hypertensive group, [16.37 (13.34–20.11) ng/mL versus 17.01 (14.23–20.79) ng/mL, p = .039]. No difference in serum osteocalcin level was found between the two groups of women (p = .675). An inverse association was observed between serum osteocalcin level and systolic blood pressure (SBP) in men (p = .004), but serum osteocalcin level was not associated with diastolic blood pressure (DBP) in men (p = .472). No associations were detected between serum osteocalcin level and SBP or DBP in women (SBP: p = .108; DBP: p = .575). A multiple stepwise regression analysis showed an inverse association between serum osteocalcin level and SBP in men after adjusting for age, smoking status, family history of hypertension, and lipid and C-reactive protein levels (standardized β = –0.074, p = .023), but the association disappeared after adjustment for body mass index, waist circumference, blood glucose, and homeostasis model assessment of insulin resistance (p = .327). Conclusions: Serum osteocalcin level was not independently associated with blood pressure in a Chinese population. |
| first_indexed | 2024-03-12T00:39:02Z |
| format | Article |
| id | doaj.art-4e5632f6a1aa4ea9aba5d5b31de01a58 |
| institution | Directory Open Access Journal |
| issn | 0803-7051 1651-1999 |
| language | English |
| last_indexed | 2024-03-12T00:39:02Z |
| publishDate | 2018-03-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Blood Pressure |
| spelling | doaj.art-4e5632f6a1aa4ea9aba5d5b31de01a582023-09-15T08:45:22ZengTaylor & Francis GroupBlood Pressure0803-70511651-19992018-03-0127210611110.1080/08037051.2017.14080051408005Association between serum osteocalcin level and blood pressure in a Chinese populationYiting Xu0Xiaojing Ma1Qin Xiong2Xiang Hu3Xueli Zhang4Yeqing Yuan5Yuqian Bao6Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusShanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes MellitusPurpose: This observational study investigated the association between serum osteocalcin level and blood pressure in a Chinese population. Materials and methods: A total of 2241 subjects (909 men and 1,332 women; age, 24–78 years) from Shanghai communities were recruited. Subjects were divided into non-hypertensive and hypertensive groups according to diagnosis of hypertension based on the 1999 World Health Organization-International Society of Hypertension Guidelines. Serum osteocalcin levels were measured using an electrochemiluminescence immunoassay. Results: Men in the hypertensive group showed lower serum osteocalcin level compared with those in the non-hypertensive group, [16.37 (13.34–20.11) ng/mL versus 17.01 (14.23–20.79) ng/mL, p = .039]. No difference in serum osteocalcin level was found between the two groups of women (p = .675). An inverse association was observed between serum osteocalcin level and systolic blood pressure (SBP) in men (p = .004), but serum osteocalcin level was not associated with diastolic blood pressure (DBP) in men (p = .472). No associations were detected between serum osteocalcin level and SBP or DBP in women (SBP: p = .108; DBP: p = .575). A multiple stepwise regression analysis showed an inverse association between serum osteocalcin level and SBP in men after adjusting for age, smoking status, family history of hypertension, and lipid and C-reactive protein levels (standardized β = –0.074, p = .023), but the association disappeared after adjustment for body mass index, waist circumference, blood glucose, and homeostasis model assessment of insulin resistance (p = .327). Conclusions: Serum osteocalcin level was not independently associated with blood pressure in a Chinese population.http://dx.doi.org/10.1080/08037051.2017.1408005osteocalcinsystolic blood pressurediastolic blood pressurehypertensionmetabolism |
| spellingShingle | Yiting Xu Xiaojing Ma Qin Xiong Xiang Hu Xueli Zhang Yeqing Yuan Yuqian Bao Association between serum osteocalcin level and blood pressure in a Chinese population Blood Pressure osteocalcin systolic blood pressure diastolic blood pressure hypertension metabolism |
| title | Association between serum osteocalcin level and blood pressure in a Chinese population |
| title_full | Association between serum osteocalcin level and blood pressure in a Chinese population |
| title_fullStr | Association between serum osteocalcin level and blood pressure in a Chinese population |
| title_full_unstemmed | Association between serum osteocalcin level and blood pressure in a Chinese population |
| title_short | Association between serum osteocalcin level and blood pressure in a Chinese population |
| title_sort | association between serum osteocalcin level and blood pressure in a chinese population |
| topic | osteocalcin systolic blood pressure diastolic blood pressure hypertension metabolism |
| url | http://dx.doi.org/10.1080/08037051.2017.1408005 |
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