Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure.
We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observati...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2017-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5665530?pdf=render |
| _version_ | 1819048111692054528 |
|---|---|
| author | Michiharu Sakamoto Naoki Morimoto Chizuru Jinno Atsushi Mahara Shuichi Ogino Shigehiko Suzuki Kenji Kusumoto Tetsuji Yamaoka |
| author_facet | Michiharu Sakamoto Naoki Morimoto Chizuru Jinno Atsushi Mahara Shuichi Ogino Shigehiko Suzuki Kenji Kusumoto Tetsuji Yamaoka |
| author_sort | Michiharu Sakamoto |
| collection | DOAJ |
| description | We report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later. Color changes of the nevus specimens were evaluated. In the 200 MPa group, the specimen color gradually regressed and turned white, and brightness values were significantly higher in the 200 MPa group than in the control group after 6 months. This indicated that melanin pigments in the pressurized nevus tissue had spontaneously degraded and regressed. Therefore, it is not necessary to remove melanin pigments in HHP-treated nevus tissue. |
| first_indexed | 2024-12-21T11:11:04Z |
| format | Article |
| id | doaj.art-4e56d2b7eecc4cb7ae0e7ce64b42efe3 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T11:11:04Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4e56d2b7eecc4cb7ae0e7ce64b42efe32022-12-21T19:06:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011211e018695810.1371/journal.pone.0186958Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure.Michiharu SakamotoNaoki MorimotoChizuru JinnoAtsushi MaharaShuichi OginoShigehiko SuzukiKenji KusumotoTetsuji YamaokaWe report a novel treatment for giant congenital melanocytic nevi (GCMN) that involves the reuse of resected nevus tissue after high hydrostatic pressurization (HHP). However, the remaining melanin pigments in the inactivated nevus tissue pose a problem; therefore, we performed a long-term observation of the color change of inactivated nevus tissue after HHP. Pressurized nevus specimens (200 MPa group, n = 9) and non-pressurized nevus tissues (control group, n = 9) were subcutaneously implanted into nude mice (BALB/c-nu) and then harvested 3, 6, and 12 months later. Color changes of the nevus specimens were evaluated. In the 200 MPa group, the specimen color gradually regressed and turned white, and brightness values were significantly higher in the 200 MPa group than in the control group after 6 months. This indicated that melanin pigments in the pressurized nevus tissue had spontaneously degraded and regressed. Therefore, it is not necessary to remove melanin pigments in HHP-treated nevus tissue.http://europepmc.org/articles/PMC5665530?pdf=render |
| spellingShingle | Michiharu Sakamoto Naoki Morimoto Chizuru Jinno Atsushi Mahara Shuichi Ogino Shigehiko Suzuki Kenji Kusumoto Tetsuji Yamaoka Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure. PLoS ONE |
| title | Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure. |
| title_full | Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure. |
| title_fullStr | Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure. |
| title_full_unstemmed | Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure. |
| title_short | Melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure. |
| title_sort | melanin pigments in the melanocytic nevus regress spontaneously after inactivation by high hydrostatic pressure |
| url | http://europepmc.org/articles/PMC5665530?pdf=render |
| work_keys_str_mv | AT michiharusakamoto melaninpigmentsinthemelanocyticnevusregressspontaneouslyafterinactivationbyhighhydrostaticpressure AT naokimorimoto melaninpigmentsinthemelanocyticnevusregressspontaneouslyafterinactivationbyhighhydrostaticpressure AT chizurujinno melaninpigmentsinthemelanocyticnevusregressspontaneouslyafterinactivationbyhighhydrostaticpressure AT atsushimahara melaninpigmentsinthemelanocyticnevusregressspontaneouslyafterinactivationbyhighhydrostaticpressure AT shuichiogino melaninpigmentsinthemelanocyticnevusregressspontaneouslyafterinactivationbyhighhydrostaticpressure AT shigehikosuzuki melaninpigmentsinthemelanocyticnevusregressspontaneouslyafterinactivationbyhighhydrostaticpressure AT kenjikusumoto melaninpigmentsinthemelanocyticnevusregressspontaneouslyafterinactivationbyhighhydrostaticpressure AT tetsujiyamaoka melaninpigmentsinthemelanocyticnevusregressspontaneouslyafterinactivationbyhighhydrostaticpressure |