Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis

Identification of disease- and headache-specific mediators and pathways in migraine using blood transcriptomic and metabolomic analysis

Abstract Background Recent data suggest that gene expression profiles of peripheral white blood cells can reflect changes in the brain. We aimed to analyze the transcriptome of peripheral blood mononuclear cells (PBMC) and changes of plasma metabolite levels of migraineurs in a self-controlled manne...

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Main Authors: Timea Aczél, Tamás Körtési, József Kun, Péter Urbán, Witold Bauer, Róbert Herczeg, Róbert Farkas, Krisztián Kovács, Barna Vásárhelyi, Gellért B. Karvaly, Attila Gyenesei, Bernadett Tuka, János Tajti, László Vécsei, Kata Bölcskei, Zsuzsanna Helyes
Format: Article
Language:English
Published: BMC 2021-10-01
Series:The Journal of Headache and Pain
Subjects:
Migraine
Transcriptomic analysis
Peripheral blood mononuclear cells
Cytokines
Mitochondrial dysfunction
Online Access:https://doi.org/10.1186/s10194-021-01285-9

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