Exercise-Induced Adaptations to Adipose Tissue Thermogenesis
Exercise training results in beneficial adaptations to numerous tissues and offers protection against metabolic disorders including obesity and type 2 diabetes. Multiple studies have indicated that both white (WAT) and brown (BAT) adipose tissue may play an important role to mediate the beneficial e...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-04-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2020.00270/full |
| _version_ | 1831691356145188864 |
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| author | Pablo Vidal Kristin I. Stanford |
| author_facet | Pablo Vidal Kristin I. Stanford |
| author_sort | Pablo Vidal |
| collection | DOAJ |
| description | Exercise training results in beneficial adaptations to numerous tissues and offers protection against metabolic disorders including obesity and type 2 diabetes. Multiple studies have indicated that both white (WAT) and brown (BAT) adipose tissue may play an important role to mediate the beneficial effects of exercise. Studies from both rodents and humans have identified exercise-induced changes in WAT including increased mitochondrial activity and glucose uptake, an altered endocrine profile, and in rodents, a beiging of the WAT. Studies investigating the effects of exercise on BAT have resulted in conflicting data in terms of mitochondrial activity, glucose uptake, and thermogenic activity in rodents and humans, and remain an important area of investigation. This review discusses the exercise-induced adaptations to white and brown adipose tissue, distinguishing important differences between rodents and humans and highlighting the latest studies in the field and their implications. |
| first_indexed | 2024-12-20T11:27:22Z |
| format | Article |
| id | doaj.art-4e591750e1644316be2f4ed6519c3ed0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-20T11:27:22Z |
| publishDate | 2020-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-4e591750e1644316be2f4ed6519c3ed02022-12-21T19:42:19ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922020-04-011110.3389/fendo.2020.00270534015Exercise-Induced Adaptations to Adipose Tissue ThermogenesisPablo VidalKristin I. StanfordExercise training results in beneficial adaptations to numerous tissues and offers protection against metabolic disorders including obesity and type 2 diabetes. Multiple studies have indicated that both white (WAT) and brown (BAT) adipose tissue may play an important role to mediate the beneficial effects of exercise. Studies from both rodents and humans have identified exercise-induced changes in WAT including increased mitochondrial activity and glucose uptake, an altered endocrine profile, and in rodents, a beiging of the WAT. Studies investigating the effects of exercise on BAT have resulted in conflicting data in terms of mitochondrial activity, glucose uptake, and thermogenic activity in rodents and humans, and remain an important area of investigation. This review discusses the exercise-induced adaptations to white and brown adipose tissue, distinguishing important differences between rodents and humans and highlighting the latest studies in the field and their implications.https://www.frontiersin.org/article/10.3389/fendo.2020.00270/fullexerciseobesitywhite adipose tissue (WAT)brown adipose tissue (BAT)thermogenesis |
| spellingShingle | Pablo Vidal Kristin I. Stanford Exercise-Induced Adaptations to Adipose Tissue Thermogenesis Frontiers in Endocrinology exercise obesity white adipose tissue (WAT) brown adipose tissue (BAT) thermogenesis |
| title | Exercise-Induced Adaptations to Adipose Tissue Thermogenesis |
| title_full | Exercise-Induced Adaptations to Adipose Tissue Thermogenesis |
| title_fullStr | Exercise-Induced Adaptations to Adipose Tissue Thermogenesis |
| title_full_unstemmed | Exercise-Induced Adaptations to Adipose Tissue Thermogenesis |
| title_short | Exercise-Induced Adaptations to Adipose Tissue Thermogenesis |
| title_sort | exercise induced adaptations to adipose tissue thermogenesis |
| topic | exercise obesity white adipose tissue (WAT) brown adipose tissue (BAT) thermogenesis |
| url | https://www.frontiersin.org/article/10.3389/fendo.2020.00270/full |
| work_keys_str_mv | AT pablovidal exerciseinducedadaptationstoadiposetissuethermogenesis AT kristinistanford exerciseinducedadaptationstoadiposetissuethermogenesis |