ROS mediated malignancy cure performance of morphological, optical, and electrically tuned Sn doped CeO2 nanostructures
To grapple with cancer, implementation of differentially cytotoxic nanomedicines have gained prime attention of the researchers across the globe. Now, ceria (CeO2) at nanoscale has emerged as a cut out therapeutic agent for malignancy treatment. Keeping this in view, we have fabricated SnxCe1-xO2 na...
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| Format: | Article |
| Language: | English |
| Published: |
AIP Publishing LLC
2017-09-01
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| Series: | AIP Advances |
| Online Access: | http://dx.doi.org/10.1063/1.4990790 |
| _version_ | 1818063877595725824 |
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| author | Fazal Abbas Javed Iqbal Qaisar Maqbool Tariq Jan Muhammad Obaid Ullah Bushra Nawaz Mudassar Nazar M. S. Hussain Naqvi Ishaq Ahmad |
| author_facet | Fazal Abbas Javed Iqbal Qaisar Maqbool Tariq Jan Muhammad Obaid Ullah Bushra Nawaz Mudassar Nazar M. S. Hussain Naqvi Ishaq Ahmad |
| author_sort | Fazal Abbas |
| collection | DOAJ |
| description | To grapple with cancer, implementation of differentially cytotoxic nanomedicines have gained prime attention of the researchers across the globe. Now, ceria (CeO2) at nanoscale has emerged as a cut out therapeutic agent for malignancy treatment. Keeping this in view, we have fabricated SnxCe1-xO2 nanostructures by facile, eco-friendly, and biocompatible hydrothermal method. Structural examinations via XRD and FT-IR spectroscopy have revealed single phase cubic-fluorite morphology while SEM analysis has depicted particle size ranging 30-50nm for pristine and doped nanostructures. UV-Vis spectroscopy investigation explored that Sn doping significantly tuned the band gap (eV) energies of SnxCe1-xO2 nanostructures which set up the base for tremendous cellular reactive oxygen species (ROS) generations involved in cancer cells’ death. To observe cytotoxicity, synthesized nanostructures were found selectively more toxic to neuroblastoma cell lines as compared to HEK-293 healthy cells. This study anticipates that SnxCe1-xO2 nanostructures, in future, might be used as nanomedicine for safer cancer therapy. |
| first_indexed | 2024-12-10T14:27:05Z |
| format | Article |
| id | doaj.art-4e59c7f0df3b41fd9638ff0cf6fb6bae |
| institution | Directory Open Access Journal |
| issn | 2158-3226 |
| language | English |
| last_indexed | 2024-12-10T14:27:05Z |
| publishDate | 2017-09-01 |
| publisher | AIP Publishing LLC |
| record_format | Article |
| series | AIP Advances |
| spelling | doaj.art-4e59c7f0df3b41fd9638ff0cf6fb6bae2022-12-22T01:45:03ZengAIP Publishing LLCAIP Advances2158-32262017-09-0179095205095205-1110.1063/1.4990790007709ADVROS mediated malignancy cure performance of morphological, optical, and electrically tuned Sn doped CeO2 nanostructuresFazal Abbas0Javed Iqbal1Qaisar Maqbool2Tariq Jan3Muhammad Obaid Ullah4Bushra Nawaz5Mudassar Nazar6M. S. Hussain Naqvi7Ishaq Ahmad8Department of Physics, Govt. Post Graduate College, Chakwal 48800, PakistanDepartment of Physics, Quaid-i-Azam University, Islamabad 44000, PakistanDepartment of Biotechnology, Virtual University of Pakistan, Lahore 54000, PakistanDepartment of Applied Sciences, National Textile University Faisalabad, 38000, PakistanDepartment of Electronics Engineering, University of Engineering and Technology, Taxila 47080, PakistanDepartment of Electronics Engineering, University of Engineering and Technology, Taxila 47080, PakistanDepartment of Biotechnology, Virtual University of Pakistan, Lahore 54000, PakistanDepartment of Biochemistry, University of Karachi, Karachi 74000, PakistanExperimental Physics Labs, National Center for Physics, Islamabad 44000, PakistanTo grapple with cancer, implementation of differentially cytotoxic nanomedicines have gained prime attention of the researchers across the globe. Now, ceria (CeO2) at nanoscale has emerged as a cut out therapeutic agent for malignancy treatment. Keeping this in view, we have fabricated SnxCe1-xO2 nanostructures by facile, eco-friendly, and biocompatible hydrothermal method. Structural examinations via XRD and FT-IR spectroscopy have revealed single phase cubic-fluorite morphology while SEM analysis has depicted particle size ranging 30-50nm for pristine and doped nanostructures. UV-Vis spectroscopy investigation explored that Sn doping significantly tuned the band gap (eV) energies of SnxCe1-xO2 nanostructures which set up the base for tremendous cellular reactive oxygen species (ROS) generations involved in cancer cells’ death. To observe cytotoxicity, synthesized nanostructures were found selectively more toxic to neuroblastoma cell lines as compared to HEK-293 healthy cells. This study anticipates that SnxCe1-xO2 nanostructures, in future, might be used as nanomedicine for safer cancer therapy.http://dx.doi.org/10.1063/1.4990790 |
| spellingShingle | Fazal Abbas Javed Iqbal Qaisar Maqbool Tariq Jan Muhammad Obaid Ullah Bushra Nawaz Mudassar Nazar M. S. Hussain Naqvi Ishaq Ahmad ROS mediated malignancy cure performance of morphological, optical, and electrically tuned Sn doped CeO2 nanostructures AIP Advances |
| title | ROS mediated malignancy cure performance of morphological, optical, and electrically tuned Sn doped CeO2 nanostructures |
| title_full | ROS mediated malignancy cure performance of morphological, optical, and electrically tuned Sn doped CeO2 nanostructures |
| title_fullStr | ROS mediated malignancy cure performance of morphological, optical, and electrically tuned Sn doped CeO2 nanostructures |
| title_full_unstemmed | ROS mediated malignancy cure performance of morphological, optical, and electrically tuned Sn doped CeO2 nanostructures |
| title_short | ROS mediated malignancy cure performance of morphological, optical, and electrically tuned Sn doped CeO2 nanostructures |
| title_sort | ros mediated malignancy cure performance of morphological optical and electrically tuned sn doped ceo2 nanostructures |
| url | http://dx.doi.org/10.1063/1.4990790 |
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