Mafa-dependent GABAergic activity promotes mouse neonatal apneas
Apneas are associated with many pathological conditions. Here, the authors show in a mouse model that stabilization of the transcription factor Mafa in brainstem GABAergic neurons may contribute to apnea, by decreasing motor drive to muscles controlling the airways.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30825-3 |
| _version_ | 1818469319996080128 |
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| author | Laure Lecoin Bowen Dempsey Alexandra Garancher Steeve Bourane Pierre-Louis Ruffault Marie-Pierre Morin-Surun Nathalie Rocques Martyn Goulding Alain Eychène Celio Pouponnot Gilles Fortin Jean Champagnat |
| author_facet | Laure Lecoin Bowen Dempsey Alexandra Garancher Steeve Bourane Pierre-Louis Ruffault Marie-Pierre Morin-Surun Nathalie Rocques Martyn Goulding Alain Eychène Celio Pouponnot Gilles Fortin Jean Champagnat |
| author_sort | Laure Lecoin |
| collection | DOAJ |
| description | Apneas are associated with many pathological conditions. Here, the authors show in a mouse model that stabilization of the transcription factor Mafa in brainstem GABAergic neurons may contribute to apnea, by decreasing motor drive to muscles controlling the airways. |
| first_indexed | 2024-04-13T21:22:08Z |
| format | Article |
| id | doaj.art-4e5a7c519af7455ca59539ab8c61aa59 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T21:22:08Z |
| publishDate | 2022-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4e5a7c519af7455ca59539ab8c61aa592022-12-22T02:29:27ZengNature PortfolioNature Communications2041-17232022-06-0113111510.1038/s41467-022-30825-3Mafa-dependent GABAergic activity promotes mouse neonatal apneasLaure Lecoin0Bowen Dempsey1Alexandra Garancher2Steeve Bourane3Pierre-Louis Ruffault4Marie-Pierre Morin-Surun5Nathalie Rocques6Martyn Goulding7Alain Eychène8Celio Pouponnot9Gilles Fortin10Jean Champagnat11Institut Curie CNRS UMR 3347, Inserm U1021, UPSaclay, bat 110 Centre UniversitaireUMR 9194 CNRS Neuro-PSI, Institut de Neurobiologie Alfred Fessard, 1 avenue de la terrasseInstitut Curie CNRS UMR 3347, Inserm U1021, UPSaclay, bat 110 Centre UniversitaireMolecular Neurobiology Laboratory, The Salk Institute for Biological StudiesDevelopmental Biology and Signal Transduction Group, Max Delbrück Center for Molecular MedicineUMR 9194 CNRS Neuro-PSI, Institut de Neurobiologie Alfred Fessard, 1 avenue de la terrasseInstitut Curie CNRS UMR 3347, Inserm U1021, UPSaclay, bat 110 Centre UniversitaireMolecular Neurobiology Laboratory, The Salk Institute for Biological StudiesInstitut Curie CNRS UMR 3347, Inserm U1021, UPSaclay, bat 110 Centre UniversitaireInstitut Curie CNRS UMR 3347, Inserm U1021, UPSaclay, bat 110 Centre UniversitaireUMR 9194 CNRS Neuro-PSI, Institut de Neurobiologie Alfred Fessard, 1 avenue de la terrasseUMR 9194 CNRS Neuro-PSI, Institut de Neurobiologie Alfred Fessard, 1 avenue de la terrasseApneas are associated with many pathological conditions. Here, the authors show in a mouse model that stabilization of the transcription factor Mafa in brainstem GABAergic neurons may contribute to apnea, by decreasing motor drive to muscles controlling the airways.https://doi.org/10.1038/s41467-022-30825-3 |
| spellingShingle | Laure Lecoin Bowen Dempsey Alexandra Garancher Steeve Bourane Pierre-Louis Ruffault Marie-Pierre Morin-Surun Nathalie Rocques Martyn Goulding Alain Eychène Celio Pouponnot Gilles Fortin Jean Champagnat Mafa-dependent GABAergic activity promotes mouse neonatal apneas Nature Communications |
| title | Mafa-dependent GABAergic activity promotes mouse neonatal apneas |
| title_full | Mafa-dependent GABAergic activity promotes mouse neonatal apneas |
| title_fullStr | Mafa-dependent GABAergic activity promotes mouse neonatal apneas |
| title_full_unstemmed | Mafa-dependent GABAergic activity promotes mouse neonatal apneas |
| title_short | Mafa-dependent GABAergic activity promotes mouse neonatal apneas |
| title_sort | mafa dependent gabaergic activity promotes mouse neonatal apneas |
| url | https://doi.org/10.1038/s41467-022-30825-3 |
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