Mafa-dependent GABAergic activity promotes mouse neonatal apneas
Apneas are associated with many pathological conditions. Here, the authors show in a mouse model that stabilization of the transcription factor Mafa in brainstem GABAergic neurons may contribute to apnea, by decreasing motor drive to muscles controlling the airways.
Main Authors: | Laure Lecoin, Bowen Dempsey, Alexandra Garancher, Steeve Bourane, Pierre-Louis Ruffault, Marie-Pierre Morin-Surun, Nathalie Rocques, Martyn Goulding, Alain Eychène, Celio Pouponnot, Gilles Fortin, Jean Champagnat |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2022-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-022-30825-3 |
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