Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar. Here, we use quantitative proteomics to analyze myelin purified from h...

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Bibliographic Details
Main Authors: Vasiliki-Ilya Gargareta, Josefine Reuschenbach, Sophie B Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-05-01
Series:eLife
Subjects:
Oligodendrocyte
myelin sheath
axon-glia interaction
label-free proteomics
scRNA-seq
cross-species comparison
Online Access:https://elifesciences.org/articles/77019

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