A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatment
Abstract Background Schizotypal personality disorder is characterized by a pervasive pattern of maladaptive behavior that has been associated with the liability for schizophrenia. Little is known about effective psychosocial interventions. This pilot non-inferiority randomized controlled trial aimed...
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-04610-5 |
| _version_ | 1797863867774140416 |
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| author | Simone Cheli Veronica Cavalletti Paul H. Lysaker Giancarlo Dimaggio Nicola Petrocchi Francesca Chiarello Consuelo Enzo Francesco Velicogna Francesco Mancini Gil Goldzweig |
| author_facet | Simone Cheli Veronica Cavalletti Paul H. Lysaker Giancarlo Dimaggio Nicola Petrocchi Francesca Chiarello Consuelo Enzo Francesco Velicogna Francesco Mancini Gil Goldzweig |
| author_sort | Simone Cheli |
| collection | DOAJ |
| description | Abstract Background Schizotypal personality disorder is characterized by a pervasive pattern of maladaptive behavior that has been associated with the liability for schizophrenia. Little is known about effective psychosocial interventions. This pilot non-inferiority randomized controlled trial aimed to compare a novel form of psychotherapy tailored for this disorder and a combination of cognitive therapy and psychopharmacological treatment. The former treatment – namely, Evolutionary Systems Therapy for Schizotypy—integrated evolutionary, metacognitively oriented, and compassion focused approaches. Methods Thirty-three participants were assessed for eligibility, twenty-four randomized on a 1:1 ratio, nineteen included in the final analysis. The treatments lasted 6 months (24 sessions). The primary outcome was change across nine measurements in personality pathology, the secondary outcomes were remission from diagnosis and pre-post changes in general symptomatology and metacognition. Results Primary outcome suggested a non-inferiority of the experimental treatment in respect to control condition. Secondary outcomes reported mixed results. There was no significant difference in terms of remission, but experimental treatment showed a larger reduction of general symptomatology (η2 = 0.558) and a larger increase in metacognition (η2 = 0.734). Conclusions This pilot study reported promising results about the effectiveness of the proposed novel approach. A confirmatory trial on large sample size is needed to provide evidence about relative effectiveness of the two treatment conditions. Trial registration ClinicalTrials.gov; NCT04764708; Registration day 21/02/2021. |
| first_indexed | 2024-04-09T22:43:42Z |
| format | Article |
| id | doaj.art-4e5cb02cb4a14981b293056e1afc905e |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-09T22:43:42Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-4e5cb02cb4a14981b293056e1afc905e2023-03-22T12:01:05ZengBMCBMC Psychiatry1471-244X2023-02-0123111410.1186/s12888-023-04610-5A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatmentSimone Cheli0Veronica Cavalletti1Paul H. Lysaker2Giancarlo Dimaggio3Nicola Petrocchi4Francesca Chiarello5Consuelo Enzo6Francesco Velicogna7Francesco Mancini8Gil Goldzweig9School of Human Health Sciences, University of FlorenceCenter for Psychology and Health (Centro Di Psicologia e Psicoterapia), Tages Charity (Tages Onlus)Department of Psychiatry, Richard L Roudebush VA Medical CenterCentro Di Terapia Metacognitiva InterpersonaleJohn Cabot UniversityCenter for Psychology and Health (Centro Di Psicologia e Psicoterapia), Tages Charity (Tages Onlus)Center for Psychology and Health (Centro Di Psicologia e Psicoterapia), Tages Charity (Tages Onlus)Center for Psychology and Health (Centro Di Psicologia e Psicoterapia), Tages Charity (Tages Onlus)Guglielmo Marconi UniversityThe Academic College of Tel Aviv YaffoAbstract Background Schizotypal personality disorder is characterized by a pervasive pattern of maladaptive behavior that has been associated with the liability for schizophrenia. Little is known about effective psychosocial interventions. This pilot non-inferiority randomized controlled trial aimed to compare a novel form of psychotherapy tailored for this disorder and a combination of cognitive therapy and psychopharmacological treatment. The former treatment – namely, Evolutionary Systems Therapy for Schizotypy—integrated evolutionary, metacognitively oriented, and compassion focused approaches. Methods Thirty-three participants were assessed for eligibility, twenty-four randomized on a 1:1 ratio, nineteen included in the final analysis. The treatments lasted 6 months (24 sessions). The primary outcome was change across nine measurements in personality pathology, the secondary outcomes were remission from diagnosis and pre-post changes in general symptomatology and metacognition. Results Primary outcome suggested a non-inferiority of the experimental treatment in respect to control condition. Secondary outcomes reported mixed results. There was no significant difference in terms of remission, but experimental treatment showed a larger reduction of general symptomatology (η2 = 0.558) and a larger increase in metacognition (η2 = 0.734). Conclusions This pilot study reported promising results about the effectiveness of the proposed novel approach. A confirmatory trial on large sample size is needed to provide evidence about relative effectiveness of the two treatment conditions. Trial registration ClinicalTrials.gov; NCT04764708; Registration day 21/02/2021.https://doi.org/10.1186/s12888-023-04610-5CompassionEvolutionEvolutionary systems therapy for schizotypyMetacognitionSchizotypal personality disorderSchizotypy |
| spellingShingle | Simone Cheli Veronica Cavalletti Paul H. Lysaker Giancarlo Dimaggio Nicola Petrocchi Francesca Chiarello Consuelo Enzo Francesco Velicogna Francesco Mancini Gil Goldzweig A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatment BMC Psychiatry Compassion Evolution Evolutionary systems therapy for schizotypy Metacognition Schizotypal personality disorder Schizotypy |
| title | A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatment |
| title_full | A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatment |
| title_fullStr | A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatment |
| title_full_unstemmed | A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatment |
| title_short | A pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatment |
| title_sort | pilot randomized controlled trial comparing a novel compassion and metacognition approach for schizotypal personality disorder with a combination of cognitive therapy and psychopharmacological treatment |
| topic | Compassion Evolution Evolutionary systems therapy for schizotypy Metacognition Schizotypal personality disorder Schizotypy |
| url | https://doi.org/10.1186/s12888-023-04610-5 |
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