Circulating chemerin levels in preeclampsia: a systematic review and meta-analysis
Abstract Background Preeclampsia (PE) is a new-onset pregnancy-specific disorder with a high prevalence that leads to over 70 000 maternal and 500 000 foetal fatalities worldwide each year. The level of chemerin, a newly identified adipokine, is increased in diabetic and obese patients. Currently, t...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | Lipids in Health and Disease |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12944-023-01941-w |
| _version_ | 1797451681774960640 |
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| author | Yangxue Yin Shuangshuang Xie Qin Xu Lingyun Liao Hongqin Chen Rong Zhou |
| author_facet | Yangxue Yin Shuangshuang Xie Qin Xu Lingyun Liao Hongqin Chen Rong Zhou |
| author_sort | Yangxue Yin |
| collection | DOAJ |
| description | Abstract Background Preeclampsia (PE) is a new-onset pregnancy-specific disorder with a high prevalence that leads to over 70 000 maternal and 500 000 foetal fatalities worldwide each year. The level of chemerin, a newly identified adipokine, is increased in diabetic and obese patients. Currently, there are several studies describing the relationship between maternal circulating chemerin levels and PE. Therefore, this study aimed to assess their association in pooled samples. Methods Four databases were systematically searched to identify potential studies that reported circulating chemerin levels in PE and normal pregnancy groups. Standardized mean differences (SMDs), 95% confidence intervals (CIs), and 95% prediction intervals (PIs) were calculated using a random-effects meta-analysis. The probability of heterogeneity was also investigated by sensitivity analysis, subgroup analysis, and meta-regression. Results Thirteen studies in 11 articles with a total of 860 PE patients and 1309 women with normal pregnancies met the inclusion criteria. The results of the meta-analysis revealed that circulating chemerin, which levels in PE patients were considerably higher than those in controls (SMD = 1.39, 95% CI: 1.02, 1.77, 95% PI: -0.07, 2.86). Moreover, sensitivity analysis determined that the outcomes of the overall pooled results were not affected after the elimination of any study. Notably, subgroup analysis demonstrated a similar expression pattern irrespective of geographic location, severity, timing of sampling, and sample size. Last, there were no factors that significantly impacted the overall estimate, according to meta-regression. Conclusions This meta-analysis is the first to assess circulating chemerin levels in PE patients. The findings indicate that circulating chemerin levels may be a potential marker to diagnose PE. |
| first_indexed | 2024-03-09T14:58:02Z |
| format | Article |
| id | doaj.art-4e5d6046a9bd426a86cd1b57fc2c05c8 |
| institution | Directory Open Access Journal |
| issn | 1476-511X |
| language | English |
| last_indexed | 2024-03-09T14:58:02Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Lipids in Health and Disease |
| spelling | doaj.art-4e5d6046a9bd426a86cd1b57fc2c05c82023-11-26T14:05:36ZengBMCLipids in Health and Disease1476-511X2023-10-0122111210.1186/s12944-023-01941-wCirculating chemerin levels in preeclampsia: a systematic review and meta-analysisYangxue Yin0Shuangshuang Xie1Qin Xu2Lingyun Liao3Hongqin Chen4Rong Zhou5Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of EducationDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of EducationDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of EducationDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of EducationDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of EducationDepartment of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) of Ministry of EducationAbstract Background Preeclampsia (PE) is a new-onset pregnancy-specific disorder with a high prevalence that leads to over 70 000 maternal and 500 000 foetal fatalities worldwide each year. The level of chemerin, a newly identified adipokine, is increased in diabetic and obese patients. Currently, there are several studies describing the relationship between maternal circulating chemerin levels and PE. Therefore, this study aimed to assess their association in pooled samples. Methods Four databases were systematically searched to identify potential studies that reported circulating chemerin levels in PE and normal pregnancy groups. Standardized mean differences (SMDs), 95% confidence intervals (CIs), and 95% prediction intervals (PIs) were calculated using a random-effects meta-analysis. The probability of heterogeneity was also investigated by sensitivity analysis, subgroup analysis, and meta-regression. Results Thirteen studies in 11 articles with a total of 860 PE patients and 1309 women with normal pregnancies met the inclusion criteria. The results of the meta-analysis revealed that circulating chemerin, which levels in PE patients were considerably higher than those in controls (SMD = 1.39, 95% CI: 1.02, 1.77, 95% PI: -0.07, 2.86). Moreover, sensitivity analysis determined that the outcomes of the overall pooled results were not affected after the elimination of any study. Notably, subgroup analysis demonstrated a similar expression pattern irrespective of geographic location, severity, timing of sampling, and sample size. Last, there were no factors that significantly impacted the overall estimate, according to meta-regression. Conclusions This meta-analysis is the first to assess circulating chemerin levels in PE patients. The findings indicate that circulating chemerin levels may be a potential marker to diagnose PE.https://doi.org/10.1186/s12944-023-01941-wPreeclampsiaChemerinAdipokineSystematic reviewMeta-analysis |
| spellingShingle | Yangxue Yin Shuangshuang Xie Qin Xu Lingyun Liao Hongqin Chen Rong Zhou Circulating chemerin levels in preeclampsia: a systematic review and meta-analysis Lipids in Health and Disease Preeclampsia Chemerin Adipokine Systematic review Meta-analysis |
| title | Circulating chemerin levels in preeclampsia: a systematic review and meta-analysis |
| title_full | Circulating chemerin levels in preeclampsia: a systematic review and meta-analysis |
| title_fullStr | Circulating chemerin levels in preeclampsia: a systematic review and meta-analysis |
| title_full_unstemmed | Circulating chemerin levels in preeclampsia: a systematic review and meta-analysis |
| title_short | Circulating chemerin levels in preeclampsia: a systematic review and meta-analysis |
| title_sort | circulating chemerin levels in preeclampsia a systematic review and meta analysis |
| topic | Preeclampsia Chemerin Adipokine Systematic review Meta-analysis |
| url | https://doi.org/10.1186/s12944-023-01941-w |
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