Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study
An association between hematological cancers and inflammatory bowel disease (IBD) has previously been suggested, but the risk of IBD in patients with myeloproliferative neoplasms (MPNs) is unknown. We conducted a nationwide population-based cohort study using Danish registries, to estimate the risk...
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MDPI AG
2020-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/12/9/2700 |
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| author | Marie Bak Tine Jess Esben Meulengracht Flachs Ann-Dorthe Zwisler Knud Juel Henrik Frederiksen |
| author_facet | Marie Bak Tine Jess Esben Meulengracht Flachs Ann-Dorthe Zwisler Knud Juel Henrik Frederiksen |
| author_sort | Marie Bak |
| collection | DOAJ |
| description | An association between hematological cancers and inflammatory bowel disease (IBD) has previously been suggested, but the risk of IBD in patients with myeloproliferative neoplasms (MPNs) is unknown. We conducted a nationwide population-based cohort study using Danish registries, to estimate the risk of IBD in individuals diagnosed with essential thrombocythemia, polycythemia vera, myelofibrosis or unclassifiable MPN during 1994–2013. MPN patients were matched 1:10 with sex- and age-matched comparisons. Everyone was followed until a diagnosis of IBD, death/emigration, or 31 December 2013. The risk of IBD overall and according to MPN subtype was calculated using Cox regression and presented as hazard ratios (HRs) with 95% confidence intervals (CI). Of 8207 MPN patients followed for 45,232 person-years, 80 were diagnosed with IBD (61 ulcerative colitis, 19 Crohn’s disease). The rate of IBD per 1000 person-years was 1.8 (95% CI:1.4–2.2) in patients vs. 0.8 (95% CI:0.7–0.8) in comparisons, and the absolute 10-year risk of IBD was 0.8% (95% CI:0.6–1.0) in patients vs. 0.4% (95% CI:0.4–0.5) in comparisons. The HR of IBD was 2.4 (95% CI:2.1–2.9) with similar HRs for ulcerative colitis and Crohn’s disease. MPN subtype risks varied from 2.1 (95% CI:1.6–2.7) to 2.8 (95% CI:2.1–3.7). Our unselected cohort study showed a more than 2-fold increased risk of IBD in MPN patients. |
| first_indexed | 2024-03-10T16:10:31Z |
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| language | English |
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| publishDate | 2020-09-01 |
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| series | Cancers |
| spelling | doaj.art-4e5d6d4b4dff4c5aa27bcc4cf22e54732023-11-20T14:30:28ZengMDPI AGCancers2072-66942020-09-01129270010.3390/cancers12092700Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort StudyMarie Bak0Tine Jess1Esben Meulengracht Flachs2Ann-Dorthe Zwisler3Knud Juel4Henrik Frederiksen5Department of Haematology, Zealand University Hospital, University of Copenhagen, 4000 Roskilde, DenmarkDepartment of Epidemiology Research, Statens Serum Institut, 2300 Copenhagen, DenmarkDepartment of Occupational and Environmental Medicine, Bispebjerg Hospital, University of Copenhagen, 2400 Copenhagen, DenmarkDanish Knowledge Centre for Rehabilitation and Palliative Care, University of Southern Denmark and Odense University Hospital, 5800 Nyborg, DenmarkNational Institute of Public Health, University of Southern Denmark, 1455 Copenhagen, DenmarkDepartment of Haematology, Odense University Hospital, 5000 Odense, DenmarkAn association between hematological cancers and inflammatory bowel disease (IBD) has previously been suggested, but the risk of IBD in patients with myeloproliferative neoplasms (MPNs) is unknown. We conducted a nationwide population-based cohort study using Danish registries, to estimate the risk of IBD in individuals diagnosed with essential thrombocythemia, polycythemia vera, myelofibrosis or unclassifiable MPN during 1994–2013. MPN patients were matched 1:10 with sex- and age-matched comparisons. Everyone was followed until a diagnosis of IBD, death/emigration, or 31 December 2013. The risk of IBD overall and according to MPN subtype was calculated using Cox regression and presented as hazard ratios (HRs) with 95% confidence intervals (CI). Of 8207 MPN patients followed for 45,232 person-years, 80 were diagnosed with IBD (61 ulcerative colitis, 19 Crohn’s disease). The rate of IBD per 1000 person-years was 1.8 (95% CI:1.4–2.2) in patients vs. 0.8 (95% CI:0.7–0.8) in comparisons, and the absolute 10-year risk of IBD was 0.8% (95% CI:0.6–1.0) in patients vs. 0.4% (95% CI:0.4–0.5) in comparisons. The HR of IBD was 2.4 (95% CI:2.1–2.9) with similar HRs for ulcerative colitis and Crohn’s disease. MPN subtype risks varied from 2.1 (95% CI:1.6–2.7) to 2.8 (95% CI:2.1–3.7). Our unselected cohort study showed a more than 2-fold increased risk of IBD in MPN patients.https://www.mdpi.com/2072-6694/12/9/2700inflammatory bowel diseasemyeloproliferative disorderscomorbidityregistry-basedcohort study |
| spellingShingle | Marie Bak Tine Jess Esben Meulengracht Flachs Ann-Dorthe Zwisler Knud Juel Henrik Frederiksen Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study Cancers inflammatory bowel disease myeloproliferative disorders comorbidity registry-based cohort study |
| title | Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study |
| title_full | Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study |
| title_fullStr | Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study |
| title_full_unstemmed | Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study |
| title_short | Risk of Inflammatory Bowel Disease in Patients with Chronic Myeloproliferative Neoplasms: A Danish Nationwide Cohort Study |
| title_sort | risk of inflammatory bowel disease in patients with chronic myeloproliferative neoplasms a danish nationwide cohort study |
| topic | inflammatory bowel disease myeloproliferative disorders comorbidity registry-based cohort study |
| url | https://www.mdpi.com/2072-6694/12/9/2700 |
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