Clinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its detection in the general population has reached a global scale. Despite the fact that in the early stages the disease is characterized by a relatively mild period, the development during its natural course of...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2018-02-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/viewFile/32840/pdf |
| _version_ | 1819168260025745408 |
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| author | A S Tikhomirova V A Kislyakov I E Baykova I G Nikitin |
| author_facet | A S Tikhomirova V A Kislyakov I E Baykova I G Nikitin |
| author_sort | A S Tikhomirova |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its detection in the general population has reached a global scale. Despite the fact that in the early stages the disease is characterized by a relatively mild period, the development during its natural course of nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma causes deterioration of long-term forecast. Growing evidence indicates that NAFLD is a complex, multifaceted etiology, involving many factors, including genetic. In the present review, we focused on the genetic component of NAFLD, namely, the role of the PNPLA3 gene polymorphism in the development and course of the disease, and States its progression, such as non-alcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma. |
| first_indexed | 2024-12-22T19:00:46Z |
| format | Article |
| id | doaj.art-4e5dc4f804a247229cd58673d46676ff |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-22T19:00:46Z |
| publishDate | 2018-02-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-4e5dc4f804a247229cd58673d46676ff2022-12-21T18:15:57Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422018-02-01902858810.26442/terarkh201890285-8829591Clinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver diseaseA S Tikhomirova0V A Kislyakov1I E Baykova2I G Nikitin3N.I. Pirogov Russian national research medical University, Ministry of health of RussiaN.I. Pirogov Russian national research medical University, Ministry of health of RussiaN.I. Pirogov Russian national research medical University, Ministry of health of RussiaN.I. Pirogov Russian national research medical University, Ministry of health of Russia; Higher Medical rehabilitation center, Ministry of health of RussiaNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its detection in the general population has reached a global scale. Despite the fact that in the early stages the disease is characterized by a relatively mild period, the development during its natural course of nonalcoholic steatohepatitis, cirrhosis and hepatocellular carcinoma causes deterioration of long-term forecast. Growing evidence indicates that NAFLD is a complex, multifaceted etiology, involving many factors, including genetic. In the present review, we focused on the genetic component of NAFLD, namely, the role of the PNPLA3 gene polymorphism in the development and course of the disease, and States its progression, such as non-alcoholic steatohepatitis, liver cirrhosis and hepatocellular carcinoma.https://ter-arkhiv.ru/0040-3660/article/viewFile/32840/pdfpnpla3non-alcoholic fatty liver diseasenonalcoholic steatohepatitisliver cirrhosispnpla3 |
| spellingShingle | A S Tikhomirova V A Kislyakov I E Baykova I G Nikitin Clinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver disease Терапевтический архив pnpla3 non-alcoholic fatty liver disease nonalcoholic steatohepatitis liver cirrhosis pnpla3 |
| title | Clinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver disease |
| title_full | Clinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver disease |
| title_fullStr | Clinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver disease |
| title_full_unstemmed | Clinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver disease |
| title_short | Clinical-morphological parallels of the PNPLA3 gene polymorphism in patients with nonalcoholic fatty liver disease |
| title_sort | clinical morphological parallels of the pnpla3 gene polymorphism in patients with nonalcoholic fatty liver disease |
| topic | pnpla3 non-alcoholic fatty liver disease nonalcoholic steatohepatitis liver cirrhosis pnpla3 |
| url | https://ter-arkhiv.ru/0040-3660/article/viewFile/32840/pdf |
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