Is there a relationship between the urine, vagina, and gut microbiota in patients with an infection of the upper urinary tract?
Introduction. Urinary tract infections of any localization are rarely considered in the context of the endogenous relationship of patient's urine microbiota and the microbiota of nearby biotopes. Nowadays, there are attempts to study the microbial interrelationships of the urinary system with n...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation
2019-04-01
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| Series: | Vestnik Urologii |
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| Online Access: | https://www.urovest.ru/jour/article/view/243 |
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| author | Y. L. Naboka M. I. Kogan I. A. Gudima E. V. Mitusova K. T. Dzhalagoniya S. N. Ivanov |
| author_facet | Y. L. Naboka M. I. Kogan I. A. Gudima E. V. Mitusova K. T. Dzhalagoniya S. N. Ivanov |
| author_sort | Y. L. Naboka |
| collection | DOAJ |
| description | Introduction. Urinary tract infections of any localization are rarely considered in the context of the endogenous relationship of patient's urine microbiota and the microbiota of nearby biotopes. Nowadays, there are attempts to study the microbial interrelationships of the urinary system with nearby biotope to find fundamentally new solutions in the study of the etiology and pathogenesis of diseases, but now this problem remains almost unexplored.Purpose of the study. Analysis of the correlations between various taxa of the microbiota isolated from urine, vagina and intestines in patients with upper urinary tract infection.Materials and methods. According to the inclusion criteria, bacteriological examination of cystic urine, feces and posterior vaginal fornix discharge was performed on 60 women (18-65 years old) with acute obstructive pyelonephritis. The material was taken, transported and examined by standard methods, but with some modifications of nutrient media. Statistical calculations were performed in R "R ver 3.2" ("R Foundation for Statistical Computing", Vienna, Austria) with generally accepted significance coefficients.Results. 26 significant correlation coefficients were found in the urinary tract and the vagina when conducting a comparative correlation analysis between the microbiota taxa, and 21 in the urinary tract and intestine. Significant correlations between the general taxa were direct and a large proportion of them were in optional anaerobic microbiota. 28 significant correlation coefficients were found in most cases between aerobic and anaerobic taxa of microorganisms in the vagina and intestines.Conclusion. The obtained significant correlation coefficients between various microbiota taxa in the three studied biotopes are evidence of the relationship of these loci. However, further research is needed on the phylotyping and genotyping of the microbiota taxa of the urinary tract, vagina and intestines of patients with urinary tract infection. |
| first_indexed | 2024-03-07T14:24:09Z |
| format | Article |
| id | doaj.art-4e5ec55c77de4ea8ae754b0427ee6277 |
| institution | Directory Open Access Journal |
| issn | 2308-6424 |
| language | Russian |
| last_indexed | 2024-03-07T14:24:09Z |
| publishDate | 2019-04-01 |
| publisher | State Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian Federation |
| record_format | Article |
| series | Vestnik Urologii |
| spelling | doaj.art-4e5ec55c77de4ea8ae754b0427ee62772024-03-06T08:56:03ZrusState Budget Educational Institute of Higher Professional Education, Rostov State Medical University, Ministry Health of Russian FederationVestnik Urologii2308-64242019-04-0171384510.21886/2308-6424-2019-7-1-38-45189Is there a relationship between the urine, vagina, and gut microbiota in patients with an infection of the upper urinary tract?Y. L. Naboka0M. I. Kogan1I. A. Gudima2E. V. Mitusova3K. T. Dzhalagoniya4S. N. Ivanov5Rostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityRostov State Medical UniversityIntroduction. Urinary tract infections of any localization are rarely considered in the context of the endogenous relationship of patient's urine microbiota and the microbiota of nearby biotopes. Nowadays, there are attempts to study the microbial interrelationships of the urinary system with nearby biotope to find fundamentally new solutions in the study of the etiology and pathogenesis of diseases, but now this problem remains almost unexplored.Purpose of the study. Analysis of the correlations between various taxa of the microbiota isolated from urine, vagina and intestines in patients with upper urinary tract infection.Materials and methods. According to the inclusion criteria, bacteriological examination of cystic urine, feces and posterior vaginal fornix discharge was performed on 60 women (18-65 years old) with acute obstructive pyelonephritis. The material was taken, transported and examined by standard methods, but with some modifications of nutrient media. Statistical calculations were performed in R "R ver 3.2" ("R Foundation for Statistical Computing", Vienna, Austria) with generally accepted significance coefficients.Results. 26 significant correlation coefficients were found in the urinary tract and the vagina when conducting a comparative correlation analysis between the microbiota taxa, and 21 in the urinary tract and intestine. Significant correlations between the general taxa were direct and a large proportion of them were in optional anaerobic microbiota. 28 significant correlation coefficients were found in most cases between aerobic and anaerobic taxa of microorganisms in the vagina and intestines.Conclusion. The obtained significant correlation coefficients between various microbiota taxa in the three studied biotopes are evidence of the relationship of these loci. However, further research is needed on the phylotyping and genotyping of the microbiota taxa of the urinary tract, vagina and intestines of patients with urinary tract infection.https://www.urovest.ru/jour/article/view/243microbiotaurinary tractvaginaintestinal tractmicrobial interrelationscomparative correlation analysis |
| spellingShingle | Y. L. Naboka M. I. Kogan I. A. Gudima E. V. Mitusova K. T. Dzhalagoniya S. N. Ivanov Is there a relationship between the urine, vagina, and gut microbiota in patients with an infection of the upper urinary tract? Vestnik Urologii microbiota urinary tract vagina intestinal tract microbial interrelations comparative correlation analysis |
| title | Is there a relationship between the urine, vagina, and gut microbiota in patients with an infection of the upper urinary tract? |
| title_full | Is there a relationship between the urine, vagina, and gut microbiota in patients with an infection of the upper urinary tract? |
| title_fullStr | Is there a relationship between the urine, vagina, and gut microbiota in patients with an infection of the upper urinary tract? |
| title_full_unstemmed | Is there a relationship between the urine, vagina, and gut microbiota in patients with an infection of the upper urinary tract? |
| title_short | Is there a relationship between the urine, vagina, and gut microbiota in patients with an infection of the upper urinary tract? |
| title_sort | is there a relationship between the urine vagina and gut microbiota in patients with an infection of the upper urinary tract |
| topic | microbiota urinary tract vagina intestinal tract microbial interrelations comparative correlation analysis |
| url | https://www.urovest.ru/jour/article/view/243 |
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