Expression of Her2/neu in Urothelial Neoplasms and its Association with Histopathological Prognostic Parameters
Background & Aims: Bladder carcinoma is the second common malignancy of the urogenital system. Bladder malignancy encompasses 5.2% of all forms of cancer. According to study, Her2/neu expression can be considered as a prognostic clinical biomarker for bladder cancer. Target therapy using novel a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Urmia University of Medical Sciences
2023-01-01
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| Series: | Journal of Research in Applied and Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijrabms.umsu.ac.ir/article-1-215-en.pdf |
| _version_ | 1827865806025785344 |
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| author | Madhulatha Guntimadugu Vijaya Lakshmi Muram Reddy Durga Kharidehal SyamSundara Rao Byna Mohan Rao Nandam Venkata Sunanda Lakshmi Gelli Bhavana Grandhi |
| author_facet | Madhulatha Guntimadugu Vijaya Lakshmi Muram Reddy Durga Kharidehal SyamSundara Rao Byna Mohan Rao Nandam Venkata Sunanda Lakshmi Gelli Bhavana Grandhi |
| author_sort | Madhulatha Guntimadugu |
| collection | DOAJ |
| description | Background & Aims: Bladder carcinoma is the second common malignancy of the urogenital system. Bladder malignancy encompasses 5.2% of all forms of cancer. According to study, Her2/neu expression can be considered as a prognostic clinical biomarker for bladder cancer. Target therapy using novel and recombinant chemodrugs such as transtuzumab can be applied in Her2/neu positive cases. Current study aimed to evaluate urothelial neoplasms incidence, to assess Her2/neu expression, and to compare its expression with prognostic factors.
Materials & Methods: The present study is a prospective study conducted in the Department of Pathology, Narayana Medical College and General Hospital, Nellore, India, for a period of 2 years from June 2019 to June 2021. All the urothelial neoplasm cases reported during the study period were included, and Her2/neu immunohistochemistry has been assessed for the cases.
Results: Among 71 bladder specimens, 48 had urothelial carcinomas (54% of high grade and 46% of low grade), and 20 had benign neoplasms. Among high-grade carcinomas, 91% were muscle invasive and among low grade, 55% were non-muscle invasive. Lateral wall is the common site of urothelial carcinoma. The mean age for high-grade carcinomas was 61-70 years, and it was associated with higher grades and stages of the tumor. In high grade and low-grade carcinomas, males outnumbered females. A significant correlation observed between tumor grade and stage. A significant association was found between Her2/neu overexpression with the grade and size of the tumor. No association was found between Her2/neu expression and age, gender, stage, and invasion.
Conclusion: It is concluded that identifying the expression of Her2/neu in urothelial carcinoma can help identify eligible candidates for targeted therapy. |
| first_indexed | 2024-03-12T14:53:33Z |
| format | Article |
| id | doaj.art-4e5f8186eb74442096122ca6803b230b |
| institution | Directory Open Access Journal |
| issn | 2717-0098 |
| language | English |
| last_indexed | 2024-03-12T14:53:33Z |
| publishDate | 2023-01-01 |
| publisher | Urmia University of Medical Sciences |
| record_format | Article |
| series | Journal of Research in Applied and Basic Medical Sciences |
| spelling | doaj.art-4e5f8186eb74442096122ca6803b230b2023-08-15T04:59:34ZengUrmia University of Medical SciencesJournal of Research in Applied and Basic Medical Sciences2717-00982023-01-01911123Expression of Her2/neu in Urothelial Neoplasms and its Association with Histopathological Prognostic ParametersMadhulatha Guntimadugu0Vijaya Lakshmi Muram Reddy1Durga Kharidehal2SyamSundara Rao Byna3Mohan Rao Nandam4Venkata Sunanda Lakshmi Gelli5Bhavana Grandhi6 Senior Resident, Department of Pathology, Narayana medical college and Hospital, Nellore, Andhra Pradesh, India Associate Professor, Department of Pathology, Narayana medical college and Hospital, Nellore. Andhra Pradesh, India Professor and HOD, Department of Pathology, Narayana medical college and Hospital, Nellore. Andhra Pradesh, India Professor, Department of Pathology, Narayana medical college and Hospital, Nellore, Andhra Pradesh, India Professor, Department of Pathology, Narayana medical college and Hospital, Nellore. Andhra Pradesh, India Assistant Professor, Narayana medical college and Hospital, Nellore, Andhra Pradesh, India Professor, Department of Pathology of Pathology, Aryana medical college and Hospital, Nellore, Andhra Pradesh, India Background & Aims: Bladder carcinoma is the second common malignancy of the urogenital system. Bladder malignancy encompasses 5.2% of all forms of cancer. According to study, Her2/neu expression can be considered as a prognostic clinical biomarker for bladder cancer. Target therapy using novel and recombinant chemodrugs such as transtuzumab can be applied in Her2/neu positive cases. Current study aimed to evaluate urothelial neoplasms incidence, to assess Her2/neu expression, and to compare its expression with prognostic factors. Materials & Methods: The present study is a prospective study conducted in the Department of Pathology, Narayana Medical College and General Hospital, Nellore, India, for a period of 2 years from June 2019 to June 2021. All the urothelial neoplasm cases reported during the study period were included, and Her2/neu immunohistochemistry has been assessed for the cases. Results: Among 71 bladder specimens, 48 had urothelial carcinomas (54% of high grade and 46% of low grade), and 20 had benign neoplasms. Among high-grade carcinomas, 91% were muscle invasive and among low grade, 55% were non-muscle invasive. Lateral wall is the common site of urothelial carcinoma. The mean age for high-grade carcinomas was 61-70 years, and it was associated with higher grades and stages of the tumor. In high grade and low-grade carcinomas, males outnumbered females. A significant correlation observed between tumor grade and stage. A significant association was found between Her2/neu overexpression with the grade and size of the tumor. No association was found between Her2/neu expression and age, gender, stage, and invasion. Conclusion: It is concluded that identifying the expression of Her2/neu in urothelial carcinoma can help identify eligible candidates for targeted therapy.http://ijrabms.umsu.ac.ir/article-1-215-en.pdftransurethral resection of bladder tumorhematoxylineosinhuman epidermal growth factor receptor 2 |
| spellingShingle | Madhulatha Guntimadugu Vijaya Lakshmi Muram Reddy Durga Kharidehal SyamSundara Rao Byna Mohan Rao Nandam Venkata Sunanda Lakshmi Gelli Bhavana Grandhi Expression of Her2/neu in Urothelial Neoplasms and its Association with Histopathological Prognostic Parameters Journal of Research in Applied and Basic Medical Sciences transurethral resection of bladder tumor hematoxylin eosin human epidermal growth factor receptor 2 |
| title | Expression of Her2/neu in Urothelial Neoplasms and its Association with Histopathological Prognostic Parameters |
| title_full | Expression of Her2/neu in Urothelial Neoplasms and its Association with Histopathological Prognostic Parameters |
| title_fullStr | Expression of Her2/neu in Urothelial Neoplasms and its Association with Histopathological Prognostic Parameters |
| title_full_unstemmed | Expression of Her2/neu in Urothelial Neoplasms and its Association with Histopathological Prognostic Parameters |
| title_short | Expression of Her2/neu in Urothelial Neoplasms and its Association with Histopathological Prognostic Parameters |
| title_sort | expression of her2 neu in urothelial neoplasms and its association with histopathological prognostic parameters |
| topic | transurethral resection of bladder tumor hematoxylin eosin human epidermal growth factor receptor 2 |
| url | http://ijrabms.umsu.ac.ir/article-1-215-en.pdf |
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