SARS-CoV-2–specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodies

SARS-CoV-2–specific memory B cells can persist in the elderly who have lost detectable neutralizing antibodies

Memory B cells (MBCs) can provide a recall response able to supplement waning antibodies (Abs) with an affinity-matured response better able to neutralize variant viruses. We studied a cohort of elderly care home residents and younger staff (median age of 87 years and 56 years, respectively), who ha...

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Bibliographic Details
Main Authors: Anna Jeffery-Smith, Alice R. Burton, Sabela Lens, Chloe Rees-Spear, Jessica Davies, Monika Patel, Robin Gopal, Luke Muir, Felicity Aiano, Katie J. Doores, J. Yimmy Chow, Shamez N. Ladhani, Maria Zambon, Laura E. McCoy, Mala K. Maini
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-01-01
Series:The Journal of Clinical Investigation
Subjects:
COVID-19
Immunology
Online Access:https://doi.org/10.1172/JCI152042

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