The role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementia
Dementia is a syndrome of acquired intellectual deficit resulting in significant impairment of social or occupational functioning. Vascular dementia (VaD) is the second most common causes of dementia after Alzheimer’s disease, causing around 15% of cases. However, unlike Alzheimer’s disease an invol...
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| Format: | Article |
| Language: | English |
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PAGEPress Publications
2022-01-01
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| Series: | Geriatric Care |
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| Online Access: | https://www.pagepressjournals.org/index.php/gc/article/view/9891 |
| _version_ | 1818214392504778752 |
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| author | Angelo Di Salvo |
| author_facet | Angelo Di Salvo |
| author_sort | Angelo Di Salvo |
| collection | DOAJ |
| description | Dementia is a syndrome of acquired intellectual deficit resulting in significant impairment of social or occupational functioning. Vascular dementia (VaD) is the second most common causes of dementia after Alzheimer’s disease, causing around 15% of cases. However, unlike Alzheimer’s disease an involvement of the cerebral cholinergic system in the pathophysiology of VaD has been hypothesized and there is no standard treatment. In the Vascular Dementia Italian Sulodexide Study (VA.D.I.S.S.) the positive results obtained with the sulodexide are worthy of note. In this study 40 elderly subjects with recent onset (less than 9 month) slight to moderate mental deterioration due to vascular origin were observed for nine months during oral treatment with sulodexide and choline alphoscerate with the aim of analyzing whether therapeutic effects can be enhanced. These preliminary results suggest that the additional therapy of choline alphoscerate with sulodexide represents a way to increase the beneficial effects of cholinergic therapies in the VaD and improve all the different examinate score: mini mental state evaluation (MMSE), basic activities of daily living (ADL), instrumental activities of daily living (IADL). |
| first_indexed | 2024-12-12T06:19:27Z |
| format | Article |
| id | doaj.art-4e62aafb66d34b62a95e0cfcdcc8619e |
| institution | Directory Open Access Journal |
| issn | 2465-1109 2465-1397 |
| language | English |
| last_indexed | 2024-12-12T06:19:27Z |
| publishDate | 2022-01-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Geriatric Care |
| spelling | doaj.art-4e62aafb66d34b62a95e0cfcdcc8619e2022-12-22T00:34:56ZengPAGEPress PublicationsGeriatric Care2465-11092465-13972022-01-017410.4081/gc.2021.9891The role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementiaAngelo Di Salvo0Simple Long-Term Care Unit, Bianchi’s Hospital of Corleone, ASP PalermoDementia is a syndrome of acquired intellectual deficit resulting in significant impairment of social or occupational functioning. Vascular dementia (VaD) is the second most common causes of dementia after Alzheimer’s disease, causing around 15% of cases. However, unlike Alzheimer’s disease an involvement of the cerebral cholinergic system in the pathophysiology of VaD has been hypothesized and there is no standard treatment. In the Vascular Dementia Italian Sulodexide Study (VA.D.I.S.S.) the positive results obtained with the sulodexide are worthy of note. In this study 40 elderly subjects with recent onset (less than 9 month) slight to moderate mental deterioration due to vascular origin were observed for nine months during oral treatment with sulodexide and choline alphoscerate with the aim of analyzing whether therapeutic effects can be enhanced. These preliminary results suggest that the additional therapy of choline alphoscerate with sulodexide represents a way to increase the beneficial effects of cholinergic therapies in the VaD and improve all the different examinate score: mini mental state evaluation (MMSE), basic activities of daily living (ADL), instrumental activities of daily living (IADL).https://www.pagepressjournals.org/index.php/gc/article/view/9891Sulodexidecholine alphosceratevascular dementiasmall vessel disease. |
| spellingShingle | Angelo Di Salvo The role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementia Geriatric Care Sulodexide choline alphoscerate vascular dementia small vessel disease. |
| title | The role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementia |
| title_full | The role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementia |
| title_fullStr | The role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementia |
| title_full_unstemmed | The role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementia |
| title_short | The role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementia |
| title_sort | role of association between the cholinergic precursor choline alphoscerate and sulodexide in vascular dementia |
| topic | Sulodexide choline alphoscerate vascular dementia small vessel disease. |
| url | https://www.pagepressjournals.org/index.php/gc/article/view/9891 |
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