Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease
The treatment of neurological disease, such as epilepsy is rather complicated. Emerging therapies such as surgery, gene therapy, stem cell transplantation, and neurostimulation have been developed to replace traditional drug therapy. However, great challenges such as the difficult localization of ep...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2024-03-01
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| Series: | Small Structures |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/sstr.202300403 |
| _version_ | 1827322443939708928 |
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| author | Yangyang Zhao Howai Ngai Fan Wang Yawei Liu Yao Sun Hongjie Zhang Shidong Wang Liang Chen Kai Liu |
| author_facet | Yangyang Zhao Howai Ngai Fan Wang Yawei Liu Yao Sun Hongjie Zhang Shidong Wang Liang Chen Kai Liu |
| author_sort | Yangyang Zhao |
| collection | DOAJ |
| description | The treatment of neurological disease, such as epilepsy is rather complicated. Emerging therapies such as surgery, gene therapy, stem cell transplantation, and neurostimulation have been developed to replace traditional drug therapy. However, great challenges such as the difficult localization of epileptic foci (EF), incomplete excision of lesioned nerves, high drug resistance, and severe side effects limit their clinical applications. As an alternative, bioinorganic materials have been emerged and show great potentials for epilepsy theranostics. Their unique physical properties, including fluorescence, magnetic resonance effect, and surface‐enhanced Raman scattering effect (SERS), give them the ability to image the localization of EF. In addition, the fluorescence and conductivity of bioinorganic materials could be further used for studying pathogenesis. Moreover, bioinorganic materials could serve as intelligent systems to deliver drugs and cooperative therapy for epilepsy. Herein, this review highlights the design and application of bioinorganic materials in the imaging, diagnosis, and therapy of epilepsy. Furthermore, light is shown on the potential bottlenecks and future perspectives of bioinorganic materials in epilepsy theranostics. |
| first_indexed | 2024-04-25T01:24:34Z |
| format | Article |
| id | doaj.art-4e62bf67122b406d992ed0dd5ab100ea |
| institution | Directory Open Access Journal |
| issn | 2688-4062 |
| language | English |
| last_indexed | 2024-04-25T01:24:34Z |
| publishDate | 2024-03-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj.art-4e62bf67122b406d992ed0dd5ab100ea2024-03-09T03:59:17ZengWiley-VCHSmall Structures2688-40622024-03-0153n/an/a10.1002/sstr.202300403Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological DiseaseYangyang Zhao0Howai Ngai1Fan Wang2Yawei Liu3Yao Sun4Hongjie Zhang5Shidong Wang6Liang Chen7Kai Liu8Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100084 ChinaDepartment of Neurosurgery Huashan Hospital Fudan University Shanghai 20040 ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 ChinaState Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 ChinaEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100084 ChinaEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100084 ChinaMusculoskeletal Tumor Center Peking University People's Hospital Beijing 100044 ChinaDepartment of Neurosurgery Huashan Hospital Fudan University Shanghai 20040 ChinaEngineering Research Center of Advanced Rare Earth Materials (Ministry of Education) Department of Chemistry Tsinghua University Beijing 100084 ChinaThe treatment of neurological disease, such as epilepsy is rather complicated. Emerging therapies such as surgery, gene therapy, stem cell transplantation, and neurostimulation have been developed to replace traditional drug therapy. However, great challenges such as the difficult localization of epileptic foci (EF), incomplete excision of lesioned nerves, high drug resistance, and severe side effects limit their clinical applications. As an alternative, bioinorganic materials have been emerged and show great potentials for epilepsy theranostics. Their unique physical properties, including fluorescence, magnetic resonance effect, and surface‐enhanced Raman scattering effect (SERS), give them the ability to image the localization of EF. In addition, the fluorescence and conductivity of bioinorganic materials could be further used for studying pathogenesis. Moreover, bioinorganic materials could serve as intelligent systems to deliver drugs and cooperative therapy for epilepsy. Herein, this review highlights the design and application of bioinorganic materials in the imaging, diagnosis, and therapy of epilepsy. Furthermore, light is shown on the potential bottlenecks and future perspectives of bioinorganic materials in epilepsy theranostics.https://doi.org/10.1002/sstr.202300403bioinorganic materialsdrug deliveryimaging locationneurological disease |
| spellingShingle | Yangyang Zhao Howai Ngai Fan Wang Yawei Liu Yao Sun Hongjie Zhang Shidong Wang Liang Chen Kai Liu Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease Small Structures bioinorganic materials drug delivery imaging location neurological disease |
| title | Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease |
| title_full | Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease |
| title_fullStr | Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease |
| title_full_unstemmed | Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease |
| title_short | Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease |
| title_sort | bioinorganic materials for imaging diagnosis and therapy of neurological disease |
| topic | bioinorganic materials drug delivery imaging location neurological disease |
| url | https://doi.org/10.1002/sstr.202300403 |
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