Recent advances in self-assembling peptide matrices as functional coatings for implantable devices
Nature has evolved numerous supramolecular machineries for modulating various cellular functions. Inspired by the assembly of these sophisticated structures in nature, the controlled assembly of synthetic peptides emerges as a promising approach to therapeutically relevant applications. The self-ass...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Chemistry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2022.1040499/full |
| _version_ | 1811313922305687552 |
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| author | Yuan Tian Lei Lu |
| author_facet | Yuan Tian Lei Lu |
| author_sort | Yuan Tian |
| collection | DOAJ |
| description | Nature has evolved numerous supramolecular machineries for modulating various cellular functions. Inspired by the assembly of these sophisticated structures in nature, the controlled assembly of synthetic peptides emerges as a promising approach to therapeutically relevant applications. The self-assembling biomimetic peptides could form well-ordered architectures through non-covalent interactions such as π-π stacking, van der Waals, electrostatic, and hydrogen bonding. In addition, the peptidic building blocks are highly biocompatible and allow facile chemical manipulation with diverse functionalities. For decades, a serious of engineered self-assembling peptides have been extensively studied as functional hydrogels for various applications. Meanwhile, the surface modification strategies based on self-assembling peptide matrices have also raised the attention of biomaterials researchers due to their programmability and 3D porous morphologies. This concise review will cover recent advances in self-assembling peptide matrices as functional coatings for implantable devices. The opportunities and challenges in this field will also be discussed. |
| first_indexed | 2024-04-13T11:03:13Z |
| format | Article |
| id | doaj.art-4e62e9d9168c4351b796cd8d25ecb5ad |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-13T11:03:13Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-4e62e9d9168c4351b796cd8d25ecb5ad2022-12-22T02:49:21ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462022-11-011010.3389/fchem.2022.10404991040499Recent advances in self-assembling peptide matrices as functional coatings for implantable devicesYuan Tian0Lei Lu1Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu, ChinaSchool and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, ChinaNature has evolved numerous supramolecular machineries for modulating various cellular functions. Inspired by the assembly of these sophisticated structures in nature, the controlled assembly of synthetic peptides emerges as a promising approach to therapeutically relevant applications. The self-assembling biomimetic peptides could form well-ordered architectures through non-covalent interactions such as π-π stacking, van der Waals, electrostatic, and hydrogen bonding. In addition, the peptidic building blocks are highly biocompatible and allow facile chemical manipulation with diverse functionalities. For decades, a serious of engineered self-assembling peptides have been extensively studied as functional hydrogels for various applications. Meanwhile, the surface modification strategies based on self-assembling peptide matrices have also raised the attention of biomaterials researchers due to their programmability and 3D porous morphologies. This concise review will cover recent advances in self-assembling peptide matrices as functional coatings for implantable devices. The opportunities and challenges in this field will also be discussed.https://www.frontiersin.org/articles/10.3389/fchem.2022.1040499/fullself-assembling peptidesfunctional coatingssurface modificationimplantable devicesnanofiber |
| spellingShingle | Yuan Tian Lei Lu Recent advances in self-assembling peptide matrices as functional coatings for implantable devices Frontiers in Chemistry self-assembling peptides functional coatings surface modification implantable devices nanofiber |
| title | Recent advances in self-assembling peptide matrices as functional coatings for implantable devices |
| title_full | Recent advances in self-assembling peptide matrices as functional coatings for implantable devices |
| title_fullStr | Recent advances in self-assembling peptide matrices as functional coatings for implantable devices |
| title_full_unstemmed | Recent advances in self-assembling peptide matrices as functional coatings for implantable devices |
| title_short | Recent advances in self-assembling peptide matrices as functional coatings for implantable devices |
| title_sort | recent advances in self assembling peptide matrices as functional coatings for implantable devices |
| topic | self-assembling peptides functional coatings surface modification implantable devices nanofiber |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2022.1040499/full |
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