Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine
Abstract Captopril (CAP) is a safe, cost-effective, and environmentally organic compound that can be used as an effective organo-catalyst. Functional groups of captopril make it capable to attach to solid support and acting as promoters in organic transformations. In this work, captopril was attache...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-47794-2 |
| _version_ | 1797452909377486848 |
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| author | Fatemeh Rezaei Heshmatollah Alinezhad Behrooz Maleki |
| author_facet | Fatemeh Rezaei Heshmatollah Alinezhad Behrooz Maleki |
| author_sort | Fatemeh Rezaei |
| collection | DOAJ |
| description | Abstract Captopril (CAP) is a safe, cost-effective, and environmentally organic compound that can be used as an effective organo-catalyst. Functional groups of captopril make it capable to attach to solid support and acting as promoters in organic transformations. In this work, captopril was attached to the surface of magnetic graphene nitride by employing a linker agent. The synthesized composite efficiently catalyzed two multicomponent reactions including the synthesis of 1,2,3,6-tetrahydropyrimidine and 2-amino-4H-chromene derivatives. A large library of functional targeted products was synthesized in mild reaction conditions. More importantly, this catalyst was stable and magnetically recycled and reused for at least five runs without losing catalytic activity. |
| first_indexed | 2024-03-09T15:15:29Z |
| format | Article |
| id | doaj.art-4e6511e3b65b432fb05e2f0a1f95ea30 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:15:29Z |
| publishDate | 2023-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4e6511e3b65b432fb05e2f0a1f95ea302023-11-26T13:05:49ZengNature PortfolioScientific Reports2045-23222023-11-0113111710.1038/s41598-023-47794-2Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidineFatemeh Rezaei0Heshmatollah Alinezhad1Behrooz Maleki2Department of Organic Chemistry, Faculty of Chemistry, University of MazandaranDepartment of Organic Chemistry, Faculty of Chemistry, University of MazandaranDepartment of Organic Chemistry, Faculty of Chemistry, University of MazandaranAbstract Captopril (CAP) is a safe, cost-effective, and environmentally organic compound that can be used as an effective organo-catalyst. Functional groups of captopril make it capable to attach to solid support and acting as promoters in organic transformations. In this work, captopril was attached to the surface of magnetic graphene nitride by employing a linker agent. The synthesized composite efficiently catalyzed two multicomponent reactions including the synthesis of 1,2,3,6-tetrahydropyrimidine and 2-amino-4H-chromene derivatives. A large library of functional targeted products was synthesized in mild reaction conditions. More importantly, this catalyst was stable and magnetically recycled and reused for at least five runs without losing catalytic activity.https://doi.org/10.1038/s41598-023-47794-2 |
| spellingShingle | Fatemeh Rezaei Heshmatollah Alinezhad Behrooz Maleki Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine Scientific Reports |
| title | Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine |
| title_full | Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine |
| title_fullStr | Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine |
| title_full_unstemmed | Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine |
| title_short | Captopril supported on magnetic graphene nitride, a sustainable and green catalyst for one-pot multicomponent synthesis of 2-amino-4H-chromene and 1,2,3,6-tetrahydropyrimidine |
| title_sort | captopril supported on magnetic graphene nitride a sustainable and green catalyst for one pot multicomponent synthesis of 2 amino 4h chromene and 1 2 3 6 tetrahydropyrimidine |
| url | https://doi.org/10.1038/s41598-023-47794-2 |
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