2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism

2′,3′,4′-Trihydroxychalcone changes estrogen receptor α regulation of genes and breast cancer cell proliferation by a reprogramming mechanism

Abstract Background Menopausal hormone therapy (MHT) is recommended for only five years to treat vasomotor symptoms and vulvovaginal atrophy because of safety concerns with long-term treatment. We investigated the ability of 2′,3′,4′-trihydroxychalcone (2′,3′,4′-THC) to modulate estrogen receptor (E...

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Bibliographic Details
Main Authors: Candice B. Herber, Chaoshen Yuan, Anthony Chang, Jen-Chywan Wang, Isaac Cohen, Dale C. Leitman
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Molecular Medicine
Subjects:
Breast cancer
Estradiol
Estrogen
Estrogen receptor
Cell proliferation
Menopause hormone therapy
Online Access:https://doi.org/10.1186/s10020-022-00470-z

Internet

https://doi.org/10.1186/s10020-022-00470-z

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