A serum interleukin-6-based analysis of patients with nasopharyngeal swab reverse-transcriptase polymerase chain reaction negative for SARS-COV-2 infection with CO-RADS 4 and 5 on computed tomography of the chest
Background: Serum interleukin 6 (IL-6) levels have been studied in the diagnostic evaluation of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19). Methods: We studied the utility of treatment with tocilizumab in COVID-19 patients (n=19) with a negative n...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-01-01
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| Series: | Journal of Clinical and Scientific Research |
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| Online Access: | http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2023;volume=12;issue=1;spage=45;epage=50;aulast=Koti |
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| author | K V Koti Reddy Pavan Kumar S Sadasiv Raju Srilakshmi Gaddam S Lakshmi Sailaja A Priyanka K Rohit Gupta P Subramanyam Aishwarya Lakshmi Pavuluri K Dinakar Reddy B Anil Kumar C Kelika Babu G Charishma K Devi Prashanthi R Ram |
| author_facet | K V Koti Reddy Pavan Kumar S Sadasiv Raju Srilakshmi Gaddam S Lakshmi Sailaja A Priyanka K Rohit Gupta P Subramanyam Aishwarya Lakshmi Pavuluri K Dinakar Reddy B Anil Kumar C Kelika Babu G Charishma K Devi Prashanthi R Ram |
| author_sort | K V Koti Reddy |
| collection | DOAJ |
| description | Background: Serum interleukin 6 (IL-6) levels have been studied in the diagnostic evaluation of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19).
Methods: We studied the utility of treatment with tocilizumab in COVID-19 patients (n=19) with a negative nasopharyngeal swab real time reverse transcriptase polymerase chain reaction (RT-PCR) test for SARS-CoV-2 who had suggestive computed tomography (CT) findings, namely, COVID-19 Reporting and Data System (CO-RADS) 4,5.
Results: Receiver operator characteristic (ROC) curve analysis showed that serum IL 6 at a cut-off of >56.9 pg/L was a predictor of mortality in nasopharyngeal swab RT-PCR negative patients with suggestive CT findings. Tocilizumab had no significant effect on the mortality.
Conclusions: In nasopharyngeal swab RT-PCR negative patients with suggestive chest CT findings, elevated serum IL-6 levels > 56.9 pg/L predicted mortality. However, treatment with tocilizumab had no effect on mortality. |
| first_indexed | 2024-03-12T22:15:50Z |
| format | Article |
| id | doaj.art-4e66a626f93b4c47a658956718ec01fd |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-03-12T22:15:50Z |
| publishDate | 2023-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-4e66a626f93b4c47a658956718ec01fd2023-07-23T11:19:40ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572023-01-01121455010.4103/jcsr.jcsr_10_21A serum interleukin-6-based analysis of patients with nasopharyngeal swab reverse-transcriptase polymerase chain reaction negative for SARS-COV-2 infection with CO-RADS 4 and 5 on computed tomography of the chestK V Koti ReddyPavan KumarS Sadasiv RajuSrilakshmi GaddamS Lakshmi SailajaA PriyankaK Rohit GuptaP SubramanyamAishwarya Lakshmi PavuluriK Dinakar ReddyB Anil KumarC Kelika BabuG CharishmaK Devi PrashanthiR RamBackground: Serum interleukin 6 (IL-6) levels have been studied in the diagnostic evaluation of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) disease (COVID-19). Methods: We studied the utility of treatment with tocilizumab in COVID-19 patients (n=19) with a negative nasopharyngeal swab real time reverse transcriptase polymerase chain reaction (RT-PCR) test for SARS-CoV-2 who had suggestive computed tomography (CT) findings, namely, COVID-19 Reporting and Data System (CO-RADS) 4,5. Results: Receiver operator characteristic (ROC) curve analysis showed that serum IL 6 at a cut-off of >56.9 pg/L was a predictor of mortality in nasopharyngeal swab RT-PCR negative patients with suggestive CT findings. Tocilizumab had no significant effect on the mortality. Conclusions: In nasopharyngeal swab RT-PCR negative patients with suggestive chest CT findings, elevated serum IL-6 levels > 56.9 pg/L predicted mortality. However, treatment with tocilizumab had no effect on mortality.http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2023;volume=12;issue=1;spage=45;epage=50;aulast=Koticomputed tomographyco radsnegativereverse transcriptase polymerase chain reactionsars cov 2 infectionserum interleukin 6tocilizumab |
| spellingShingle | K V Koti Reddy Pavan Kumar S Sadasiv Raju Srilakshmi Gaddam S Lakshmi Sailaja A Priyanka K Rohit Gupta P Subramanyam Aishwarya Lakshmi Pavuluri K Dinakar Reddy B Anil Kumar C Kelika Babu G Charishma K Devi Prashanthi R Ram A serum interleukin-6-based analysis of patients with nasopharyngeal swab reverse-transcriptase polymerase chain reaction negative for SARS-COV-2 infection with CO-RADS 4 and 5 on computed tomography of the chest Journal of Clinical and Scientific Research computed tomography co rads negative reverse transcriptase polymerase chain reaction sars cov 2 infection serum interleukin 6 tocilizumab |
| title | A serum interleukin-6-based analysis of patients with nasopharyngeal swab reverse-transcriptase polymerase chain reaction negative for SARS-COV-2 infection with CO-RADS 4 and 5 on computed tomography of the chest |
| title_full | A serum interleukin-6-based analysis of patients with nasopharyngeal swab reverse-transcriptase polymerase chain reaction negative for SARS-COV-2 infection with CO-RADS 4 and 5 on computed tomography of the chest |
| title_fullStr | A serum interleukin-6-based analysis of patients with nasopharyngeal swab reverse-transcriptase polymerase chain reaction negative for SARS-COV-2 infection with CO-RADS 4 and 5 on computed tomography of the chest |
| title_full_unstemmed | A serum interleukin-6-based analysis of patients with nasopharyngeal swab reverse-transcriptase polymerase chain reaction negative for SARS-COV-2 infection with CO-RADS 4 and 5 on computed tomography of the chest |
| title_short | A serum interleukin-6-based analysis of patients with nasopharyngeal swab reverse-transcriptase polymerase chain reaction negative for SARS-COV-2 infection with CO-RADS 4 and 5 on computed tomography of the chest |
| title_sort | serum interleukin 6 based analysis of patients with nasopharyngeal swab reverse transcriptase polymerase chain reaction negative for sars cov 2 infection with co rads 4 and 5 on computed tomography of the chest |
| topic | computed tomography co rads negative reverse transcriptase polymerase chain reaction sars cov 2 infection serum interleukin 6 tocilizumab |
| url | http://www.jcsr.co.in/article.asp?issn=2277-5706;year=2023;volume=12;issue=1;spage=45;epage=50;aulast=Koti |
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