Autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer
Abstract Prostate cancer is a common malignant tumor, which can spread to multiple organs in the body. Metastatic disease is the dominant reason of death for patients with prostate cancer. Prostate cancer usually transfers to bone. Bone metastases are related to pathologic fracture, pain, and reduce...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-10-01
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| Series: | Cell Death and Disease |
| Online Access: | https://doi.org/10.1038/s41419-021-04181-x |
| _version_ | 1818689345015513088 |
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| author | YouZhi Wang Ning Wu Ning Jiang |
| author_facet | YouZhi Wang Ning Wu Ning Jiang |
| author_sort | YouZhi Wang |
| collection | DOAJ |
| description | Abstract Prostate cancer is a common malignant tumor, which can spread to multiple organs in the body. Metastatic disease is the dominant reason of death for patients with prostate cancer. Prostate cancer usually transfers to bone. Bone metastases are related to pathologic fracture, pain, and reduced survival. There are many known targets for prostate cancer treatment, including androgen receptor (AR) axis, but drug resistance and metastasis eventually develop in advanced disease, suggesting the necessity to better understand the resistance mechanisms and consider multi-target medical treatment. Because of the limitations of approved treatments, further research into other potential targets is necessary. Metastasis is an important marker of cancer development, involving numerous factors, such as AKT, EMT, ECM, tumor angiogenesis, the development of inflammatory tumor microenvironment, and defect in programmed cell death. In tumor metastasis, programmed cell death (autophagy, apoptosis, and necroptosis) plays a key role. Malignant cancer cells have to overcome the different forms of cell death to transfer. The article sums up the recent studies on the mechanism of bone metastasis involving key regulatory factors such as macrophages and AKT and further discusses as to how regulating autophagy is crucial in relieving prostate cancer bone metastasis. |
| first_indexed | 2024-12-17T12:08:37Z |
| format | Article |
| id | doaj.art-4e66efe90bd34fce93a39b370ab3fc76 |
| institution | Directory Open Access Journal |
| issn | 2041-4889 |
| language | English |
| last_indexed | 2024-12-17T12:08:37Z |
| publishDate | 2021-10-01 |
| publisher | Nature Publishing Group |
| record_format | Article |
| series | Cell Death and Disease |
| spelling | doaj.art-4e66efe90bd34fce93a39b370ab3fc762022-12-21T21:49:31ZengNature Publishing GroupCell Death and Disease2041-48892021-10-0112101810.1038/s41419-021-04181-xAutophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancerYouZhi Wang0Ning Wu1Ning Jiang2Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical UniversityThe First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and TherapyDepartment of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical UniversityAbstract Prostate cancer is a common malignant tumor, which can spread to multiple organs in the body. Metastatic disease is the dominant reason of death for patients with prostate cancer. Prostate cancer usually transfers to bone. Bone metastases are related to pathologic fracture, pain, and reduced survival. There are many known targets for prostate cancer treatment, including androgen receptor (AR) axis, but drug resistance and metastasis eventually develop in advanced disease, suggesting the necessity to better understand the resistance mechanisms and consider multi-target medical treatment. Because of the limitations of approved treatments, further research into other potential targets is necessary. Metastasis is an important marker of cancer development, involving numerous factors, such as AKT, EMT, ECM, tumor angiogenesis, the development of inflammatory tumor microenvironment, and defect in programmed cell death. In tumor metastasis, programmed cell death (autophagy, apoptosis, and necroptosis) plays a key role. Malignant cancer cells have to overcome the different forms of cell death to transfer. The article sums up the recent studies on the mechanism of bone metastasis involving key regulatory factors such as macrophages and AKT and further discusses as to how regulating autophagy is crucial in relieving prostate cancer bone metastasis.https://doi.org/10.1038/s41419-021-04181-x |
| spellingShingle | YouZhi Wang Ning Wu Ning Jiang Autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer Cell Death and Disease |
| title | Autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer |
| title_full | Autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer |
| title_fullStr | Autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer |
| title_full_unstemmed | Autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer |
| title_short | Autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer |
| title_sort | autophagy provides a conceptual therapeutic framework for bone metastasis from prostate cancer |
| url | https://doi.org/10.1038/s41419-021-04181-x |
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