Statins Do Not Directly Inhibit the Activity of Major Epigenetic Modifying Enzymes

Statins Do Not Directly Inhibit the Activity of Major Epigenetic Modifying Enzymes

The potential anticancer effects of statins—a widely used class of cholesterol lowering drugs—has generated significant interest, as has the use of epigenetic modifying drugs such as HDAC and DNMT inhibitors. We set out to investigate the effect of statin drugs on epigenetic modifications in multipl...

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Bibliographic Details
Main Authors: Stephanie Bridgeman, Wendy Northrop, Gaewyn Ellison, Thiru Sabapathy, Phillip E. Melton, Philip Newsholme, Cyril D. S. Mamotte
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
HMG-CoA reductase inhibitors
epigenetics
histone acetylation
DNA methylation
HDAC inhibitors
DNMT inhibitors
Online Access:https://www.mdpi.com/2072-6694/11/4/516

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