Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases
Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2022.892682/full |
| _version_ | 1819046119369342976 |
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| author | Marija Gjorgjievska Sanja Mehandziska Aleksandra Stajkovska Slavica Pecioska-Dokuzovska Anica Dimovska Idriz Durmish Sara Ismail Teodora Pavlovska Antonija Stojchevska Haris Amedi Jasna Andonova Marija Nikolovska Sara Velickovikj Zan Mitrev Ivan Kungulovski Goran Kungulovski |
| author_facet | Marija Gjorgjievska Sanja Mehandziska Aleksandra Stajkovska Slavica Pecioska-Dokuzovska Anica Dimovska Idriz Durmish Sara Ismail Teodora Pavlovska Antonija Stojchevska Haris Amedi Jasna Andonova Marija Nikolovska Sara Velickovikj Zan Mitrev Ivan Kungulovski Goran Kungulovski |
| author_sort | Marija Gjorgjievska |
| collection | DOAJ |
| description | Trends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR identified omicron BA.1 at early time-points, which was replaced by omicron BA.2 at later time-points of the infection. The timeline of our data supports the proposition that BA.2 outcompetes BA.1 in a real-life scenario, and in time becomes the dominant variant in the upper respiratory tract of the host. |
| first_indexed | 2024-12-21T10:39:24Z |
| format | Article |
| id | doaj.art-4e68982b4a8e456286e5f9241642272a |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-21T10:39:24Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-4e68982b4a8e456286e5f9241642272a2022-12-21T19:06:58ZengFrontiers Media S.A.Frontiers in Genetics1664-80212022-04-011310.3389/fgene.2022.892682892682Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection CasesMarija Gjorgjievska0Sanja Mehandziska1Aleksandra Stajkovska2Slavica Pecioska-Dokuzovska3Anica Dimovska4Idriz Durmish5Sara Ismail6Teodora Pavlovska7Antonija Stojchevska8Haris Amedi9Jasna Andonova10Marija Nikolovska11Sara Velickovikj12Zan Mitrev13Ivan Kungulovski14Goran Kungulovski15Zan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaBio Engineering LLC, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaZan Mitrev Clinic, Skopje, North MacedoniaBio Engineering LLC, Skopje, North MacedoniaBio Engineering LLC, Skopje, North MacedoniaTrends from around the world suggest that the omicron BA.2 subvariant is increasing in proportion to the original BA.1 subvariant. Here we report two cases of co-infection with omicron BA.1 and omicron BA.2 in co-exposed individuals. In both individuals, genome sequencing and/or S-gene specific PCR identified omicron BA.1 at early time-points, which was replaced by omicron BA.2 at later time-points of the infection. The timeline of our data supports the proposition that BA.2 outcompetes BA.1 in a real-life scenario, and in time becomes the dominant variant in the upper respiratory tract of the host.https://www.frontiersin.org/articles/10.3389/fgene.2022.892682/fullCOVID-19co-infectionomicronnext-generation sequencingSARS- CoV2 |
| spellingShingle | Marija Gjorgjievska Sanja Mehandziska Aleksandra Stajkovska Slavica Pecioska-Dokuzovska Anica Dimovska Idriz Durmish Sara Ismail Teodora Pavlovska Antonija Stojchevska Haris Amedi Jasna Andonova Marija Nikolovska Sara Velickovikj Zan Mitrev Ivan Kungulovski Goran Kungulovski Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases Frontiers in Genetics COVID-19 co-infection omicron next-generation sequencing SARS- CoV2 |
| title | Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases |
| title_full | Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases |
| title_fullStr | Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases |
| title_full_unstemmed | Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases |
| title_short | Case Report: Omicron BA.2 Subvariant of SARS-CoV-2 Outcompetes BA.1 in Two Co-infection Cases |
| title_sort | case report omicron ba 2 subvariant of sars cov 2 outcompetes ba 1 in two co infection cases |
| topic | COVID-19 co-infection omicron next-generation sequencing SARS- CoV2 |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2022.892682/full |
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