Hypoxia induced lactate acidosis modulates tumor microenvironment and lipid reprogramming to sustain the cancer cell survival

Hypoxia induced lactate acidosis modulates tumor microenvironment and lipid reprogramming to sustain the cancer cell survival

It is well known that solid hypoxic tumour cells oxidise glucose through glycolysis, and the end product of this pathway is fermented into lactate which accumulates in the tumour microenvironment (TME). Initially, it was proclaimed that cancer cells cannot use lactate; therefore, they dump it into t...

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Bibliographic Details
Main Authors: Lakhveer Singh, Lakshmi Nair, Dinesh Kumar, Mandeep Kumar Arora, Sakshi Bajaj, Manoj Gadewar, Shashank Shekher Mishra, Santosh Kumar Rath, Amit Kumar Dubey, Gaurav Kaithwas, Manjusha Choudhary, Manjari Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Oncology
Subjects:
hypoxia
HIF-1α
lactate
angiogenesis
invasiveness
resistance
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1034205/full

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