Acetaldehyde as the first hit of addictive behaviour
Unhealthy alcohol use is common in the Western society, which puts risk of health consequences, causing multiple behavioural injuries. Increasing evidence focuses on acetaldehyde, the first metabolite of ethanol, as the mediator of the several behavioural actions of alcohol, including its rewarding...
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| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2016-12-01
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| Series: | Journal of Biological Research |
| Subjects: | |
| Online Access: | http://www.pagepressjournals.org/index.php/jbr/article/view/6206 |
| _version_ | 1818305141535670272 |
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| author | Angela Cavallaro Gianluca Lavanco Carla Cannizzaro Anna Brancato Danila Di Majo Marco Giammanco Francesco Martines Irene Miccichè Fulvio Plescia |
| author_facet | Angela Cavallaro Gianluca Lavanco Carla Cannizzaro Anna Brancato Danila Di Majo Marco Giammanco Francesco Martines Irene Miccichè Fulvio Plescia |
| author_sort | Angela Cavallaro |
| collection | DOAJ |
| description | Unhealthy alcohol use is common in the Western society, which puts risk of health consequences, causing multiple behavioural injuries. Increasing evidence focuses on acetaldehyde, the first metabolite of ethanol, as the mediator of the several behavioural actions of alcohol, including its rewarding and motivational effects. In particular, acetaldehyde induces dopamine release in the nucleus accumbens modulating primary alcohol rewarding effect, drug seeking, and relapse behaviour. Recent behavioural studies point at acetaldehyde as a drug of abuse since its oral self-administration is induced and maintained in an operant/conflict paradigm. These findings provide further evidence on the role played by the acetaldehyde as a mediator of the effects of alcohol and focus attention on this molecule to arrange a more effective strategy, aimed at the prevention and treatment of alcohol abuse. Thus, the aim of this review is to summarize latest results on the role of acetaldehyde as the mediator of ethanol-central effects focusing on its capacity to induce an addictive behaviour. |
| first_indexed | 2024-12-13T06:21:52Z |
| format | Article |
| id | doaj.art-4e6d2df59e524a9f9b3ce328c57bd997 |
| institution | Directory Open Access Journal |
| issn | 1826-8838 2284-0230 |
| language | English |
| last_indexed | 2024-12-13T06:21:52Z |
| publishDate | 2016-12-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Journal of Biological Research |
| spelling | doaj.art-4e6d2df59e524a9f9b3ce328c57bd9972022-12-21T23:56:49ZengPAGEPress PublicationsJournal of Biological Research1826-88382284-02302016-12-0189210.4081/jbr.2016.62065058Acetaldehyde as the first hit of addictive behaviourAngela Cavallaro0Gianluca Lavanco1Carla Cannizzaro2Anna Brancato3Danila Di Majo4Marco Giammanco5Francesco Martines6Irene Miccichè7Fulvio Plescia8Department of Sciences for Health Promotion and Mother and Child Care Giuseppe D’Alessandro, University of Palermo, PalermoDepartment of Sciences for Health Promotion and Mother and Child Care Giuseppe D’Alessandro, University of Palermo, PalermoDepartment of Sciences for Health Promotion and Mother and Child Care Giuseppe D’Alessandro, University of Palermo, PalermoDepartment of Sciences for Health Promotion and Mother and Child Care Giuseppe D’Alessandro, University of Palermo, PalermoDepartment of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, PalermoDepartment of Experimental Biomedicine and Clinical Neurosciences, University of Palermo, PalermoDepartment of Experimental Biomedicine and Clinical Neurosciences, ENT Section, University of Palermo, PalermoDepartment of Sciences for Health Promotion and Mother and Child Care Giuseppe D’Alessandro, University of Palermo, PalermoDepartment of Sciences for Health Promotion and Mother and Child Care Giuseppe D’Alessandro, University of Palermo, PalermoUnhealthy alcohol use is common in the Western society, which puts risk of health consequences, causing multiple behavioural injuries. Increasing evidence focuses on acetaldehyde, the first metabolite of ethanol, as the mediator of the several behavioural actions of alcohol, including its rewarding and motivational effects. In particular, acetaldehyde induces dopamine release in the nucleus accumbens modulating primary alcohol rewarding effect, drug seeking, and relapse behaviour. Recent behavioural studies point at acetaldehyde as a drug of abuse since its oral self-administration is induced and maintained in an operant/conflict paradigm. These findings provide further evidence on the role played by the acetaldehyde as a mediator of the effects of alcohol and focus attention on this molecule to arrange a more effective strategy, aimed at the prevention and treatment of alcohol abuse. Thus, the aim of this review is to summarize latest results on the role of acetaldehyde as the mediator of ethanol-central effects focusing on its capacity to induce an addictive behaviour.http://www.pagepressjournals.org/index.php/jbr/article/view/6206AcetaldehydeEthanol-related effectsAddictive behaviour |
| spellingShingle | Angela Cavallaro Gianluca Lavanco Carla Cannizzaro Anna Brancato Danila Di Majo Marco Giammanco Francesco Martines Irene Miccichè Fulvio Plescia Acetaldehyde as the first hit of addictive behaviour Journal of Biological Research Acetaldehyde Ethanol-related effects Addictive behaviour |
| title | Acetaldehyde as the first hit of addictive behaviour |
| title_full | Acetaldehyde as the first hit of addictive behaviour |
| title_fullStr | Acetaldehyde as the first hit of addictive behaviour |
| title_full_unstemmed | Acetaldehyde as the first hit of addictive behaviour |
| title_short | Acetaldehyde as the first hit of addictive behaviour |
| title_sort | acetaldehyde as the first hit of addictive behaviour |
| topic | Acetaldehyde Ethanol-related effects Addictive behaviour |
| url | http://www.pagepressjournals.org/index.php/jbr/article/view/6206 |
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