How to switch a master switch
The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2013-07-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/01159 |
| _version_ | 1818028301914996736 |
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| author | Christopher Hein Alfred Wittinghofer Volker Dötsch |
| author_facet | Christopher Hein Alfred Wittinghofer Volker Dötsch |
| author_sort | Christopher Hein |
| collection | DOAJ |
| description | The crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras. |
| first_indexed | 2024-12-10T05:01:38Z |
| format | Article |
| id | doaj.art-4e6f549d7d6f4d639e196f61b16a1382 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-12-10T05:01:38Z |
| publishDate | 2013-07-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-4e6f549d7d6f4d639e196f61b16a13822022-12-22T02:01:23ZengeLife Sciences Publications LtdeLife2050-084X2013-07-01210.7554/eLife.01159How to switch a master switchChristopher Hein0Alfred Wittinghofer1Volker Dötsch2Institute of Biophysical Chemistry and the Buchmann Institute of Molecular Life Sciences, Goethe University, Frankfurt, GermanyMax Planck Institute of Molecular Physiology, Dortmund, GermanyInstitute of Biophysical Chemistry and the Buchmann Institute of Molecular Life Sciences, Goethe University, Frankfurt, GermanyThe crystal structure of a nucleotide exchange factor in white blood cells reveals an autoinhibitory mechanism that reinforces the switch-like behaviour of the signalling protein Ras.https://elifesciences.org/articles/01159cell signallingnucleotide exchange factordiacylglycerol |
| spellingShingle | Christopher Hein Alfred Wittinghofer Volker Dötsch How to switch a master switch eLife cell signalling nucleotide exchange factor diacylglycerol |
| title | How to switch a master switch |
| title_full | How to switch a master switch |
| title_fullStr | How to switch a master switch |
| title_full_unstemmed | How to switch a master switch |
| title_short | How to switch a master switch |
| title_sort | how to switch a master switch |
| topic | cell signalling nucleotide exchange factor diacylglycerol |
| url | https://elifesciences.org/articles/01159 |
| work_keys_str_mv | AT christopherhein howtoswitchamasterswitch AT alfredwittinghofer howtoswitchamasterswitch AT volkerdotsch howtoswitchamasterswitch |