PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions
Abstract Charge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-88992-0 |
| _version_ | 1818717128371470336 |
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| author | Sonia T. Nicolaou Max Hebditch Owen J. Jonathan Chandra S. Verma Jim Warwicker |
| author_facet | Sonia T. Nicolaou Max Hebditch Owen J. Jonathan Chandra S. Verma Jim Warwicker |
| author_sort | Sonia T. Nicolaou |
| collection | DOAJ |
| description | Abstract Charge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence would assist in the functional interpretation of IDPs and IDRs. PhosIDP is a web tool that shows variation of charge and fold propensity upon phosphorylation. In combination with the displayed location of protein domains, the information provided by the web tool can lead to functional inferences for the consequences of phosphorylation. IDRs are components of many proteins that form biological condensates. It is shown that IDR charge, and its modulation by phosphorylation, is more tightly controlled for proteins that are essential for condensate formation than for those present in condensates but inessential. |
| first_indexed | 2024-12-17T19:30:14Z |
| format | Article |
| id | doaj.art-4e6fab92ba564343bcfe957238eafca2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T19:30:14Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4e6fab92ba564343bcfe957238eafca22022-12-21T21:35:16ZengNature PortfolioScientific Reports2045-23222021-05-011111710.1038/s41598-021-88992-0PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regionsSonia T. Nicolaou0Max Hebditch1Owen J. Jonathan2Chandra S. Verma3Jim Warwicker4School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Institute of Biotechnology, University of ManchesterSchool of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Institute of Biotechnology, University of ManchesterSchool of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Institute of Biotechnology, University of ManchesterBioinformatics Institute, Agency for Science, Technology, and Research (A*STAR)School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Institute of Biotechnology, University of ManchesterAbstract Charge is a key determinant of intrinsically disordered protein (IDP) and intrinsically disordered region (IDR) properties. IDPs and IDRs are enriched in sites of phosphorylation, which alters charge. Visualizing the degree to which phosphorylation modulates the charge profile of a sequence would assist in the functional interpretation of IDPs and IDRs. PhosIDP is a web tool that shows variation of charge and fold propensity upon phosphorylation. In combination with the displayed location of protein domains, the information provided by the web tool can lead to functional inferences for the consequences of phosphorylation. IDRs are components of many proteins that form biological condensates. It is shown that IDR charge, and its modulation by phosphorylation, is more tightly controlled for proteins that are essential for condensate formation than for those present in condensates but inessential.https://doi.org/10.1038/s41598-021-88992-0 |
| spellingShingle | Sonia T. Nicolaou Max Hebditch Owen J. Jonathan Chandra S. Verma Jim Warwicker PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions Scientific Reports |
| title | PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions |
| title_full | PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions |
| title_fullStr | PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions |
| title_full_unstemmed | PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions |
| title_short | PhosIDP: a web tool to visualize the location of phosphorylation sites in disordered regions |
| title_sort | phosidp a web tool to visualize the location of phosphorylation sites in disordered regions |
| url | https://doi.org/10.1038/s41598-021-88992-0 |
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