The Implication of Autophagy in Gastric Cancer Progression
Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. The three entirely variable entities have distinct epidemiology, molecular characteristics, prognosis, and strategies for clinical management. However, many gastric tumors appear to be r...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/12/1304 |
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| author | Evangelos Koustas Eleni-Myrto Trifylli Panagiotis Sarantis Nikolaos I. Kontolatis Christos Damaskos Nikolaos Garmpis Christos Vallilas Anna Garmpi Athanasios G. Papavassiliou Michalis V. Karamouzis |
| author_facet | Evangelos Koustas Eleni-Myrto Trifylli Panagiotis Sarantis Nikolaos I. Kontolatis Christos Damaskos Nikolaos Garmpis Christos Vallilas Anna Garmpi Athanasios G. Papavassiliou Michalis V. Karamouzis |
| author_sort | Evangelos Koustas |
| collection | DOAJ |
| description | Gastric cancer is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. The three entirely variable entities have distinct epidemiology, molecular characteristics, prognosis, and strategies for clinical management. However, many gastric tumors appear to be resistant to current chemotherapeutic agents. Moreover, a significant number of gastric cancer patients, with a lack of optimal treatment strategies, have reduced survival. In recent years, multiple research data have highlighted the importance of autophagy, an essential catabolic process of cytoplasmic component digestion, in cancer. The role of autophagy as a tumor suppressor or tumor promoter mechanism remains controversial. The multistep nature of the autophagy process offers a wide array of targetable points for designing novel chemotherapeutic strategies. The purpose of this review is to summarize the current knowledge regarding the interplay between gastric cancer development and the autophagy process and decipher the role of autophagy in this kind of cancer. A plethora of different agents that direct or indirect target autophagy may be a novel therapeutic approach for gastric cancer patients. |
| first_indexed | 2024-03-10T03:43:49Z |
| format | Article |
| id | doaj.art-4e6fecf5634e4172a84cc89b83c0e283 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-10T03:43:49Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-4e6fecf5634e4172a84cc89b83c0e2832023-11-23T09:13:32ZengMDPI AGLife2075-17292021-11-011112130410.3390/life11121304The Implication of Autophagy in Gastric Cancer ProgressionEvangelos Koustas0Eleni-Myrto Trifylli1Panagiotis Sarantis2Nikolaos I. Kontolatis3Christos Damaskos4Nikolaos Garmpis5Christos Vallilas6Anna Garmpi7Athanasios G. Papavassiliou8Michalis V. Karamouzis9Molecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceRenal Transplantation Unit, ‘Laiko’ General Hospital, 11527 Athens, Greece‘N.S. Christeas’ Laboratory of Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceFirst Department of Pathology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceMolecular Oncology Unit, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, GreeceGastric cancer is the fifth most common malignancy and the third leading cause of cancer-related death worldwide. The three entirely variable entities have distinct epidemiology, molecular characteristics, prognosis, and strategies for clinical management. However, many gastric tumors appear to be resistant to current chemotherapeutic agents. Moreover, a significant number of gastric cancer patients, with a lack of optimal treatment strategies, have reduced survival. In recent years, multiple research data have highlighted the importance of autophagy, an essential catabolic process of cytoplasmic component digestion, in cancer. The role of autophagy as a tumor suppressor or tumor promoter mechanism remains controversial. The multistep nature of the autophagy process offers a wide array of targetable points for designing novel chemotherapeutic strategies. The purpose of this review is to summarize the current knowledge regarding the interplay between gastric cancer development and the autophagy process and decipher the role of autophagy in this kind of cancer. A plethora of different agents that direct or indirect target autophagy may be a novel therapeutic approach for gastric cancer patients.https://www.mdpi.com/2075-1729/11/12/1304autophagyautophagy inducersautophagy inhibitorsautophagy regulationchemotherapygastric cancer |
| spellingShingle | Evangelos Koustas Eleni-Myrto Trifylli Panagiotis Sarantis Nikolaos I. Kontolatis Christos Damaskos Nikolaos Garmpis Christos Vallilas Anna Garmpi Athanasios G. Papavassiliou Michalis V. Karamouzis The Implication of Autophagy in Gastric Cancer Progression Life autophagy autophagy inducers autophagy inhibitors autophagy regulation chemotherapy gastric cancer |
| title | The Implication of Autophagy in Gastric Cancer Progression |
| title_full | The Implication of Autophagy in Gastric Cancer Progression |
| title_fullStr | The Implication of Autophagy in Gastric Cancer Progression |
| title_full_unstemmed | The Implication of Autophagy in Gastric Cancer Progression |
| title_short | The Implication of Autophagy in Gastric Cancer Progression |
| title_sort | implication of autophagy in gastric cancer progression |
| topic | autophagy autophagy inducers autophagy inhibitors autophagy regulation chemotherapy gastric cancer |
| url | https://www.mdpi.com/2075-1729/11/12/1304 |
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