Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca
Aim of study: The purpose of the study was to evaluate the association of thyroid dysfunction occurring in pediatric patients treated for brain tumors. Patients and methods: A total of 255 patients with brain tumors were treated between 2001 and 2018 at the “Prof. Dr. Ion ChiricuțăR...
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| Format: | Article |
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MDPI AG
2020-03-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/3/142 |
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| author | Maria Margareta Cosnarovici Andra Piciu Eduard-Alexandru Bonci Marius-Ioan Bădan Claudiu-Iulian Bădulescu Andreea-Ioana Stefan Alexandru Mester Rodica Cosnarovici Maria-Iulia Larg |
| author_facet | Maria Margareta Cosnarovici Andra Piciu Eduard-Alexandru Bonci Marius-Ioan Bădan Claudiu-Iulian Bădulescu Andreea-Ioana Stefan Alexandru Mester Rodica Cosnarovici Maria-Iulia Larg |
| author_sort | Maria Margareta Cosnarovici |
| collection | DOAJ |
| description | Aim of study: The purpose of the study was to evaluate the association of thyroid dysfunction occurring in pediatric patients treated for brain tumors. Patients and methods: A total of 255 patients with brain tumors were treated between 2001 and 2018 at the “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca. Due to a minimum follow-up of 4 years, we studied 184 out of the 255 patients. The cohort included 69 girls (37.5%) and 109 boys (62.5%), with a median age of 8.4 years. The evaluated tumors included medulloblastomas (47 patients), astrocytomas (44 patients), ependymomas (22 patients), gliomas (20 patients), germ cell tumors (12 patients), primitive neuroectodermal tumors (4 patients), as well as other types of tumors (15 patients); in 20 of the cases, biopsy could not be performed. Results: There was a 60% overall survival rate; among the 120 surviving patients, 11 (9.1%) were diagnosed with iatrogenic thyroid disease. We observed an important number of iatrogenic thyroid disease cases in this group of patients, thus revealing the importance of long-term thyroid function evaluation in all children who finalized their treatment for brain tumors. Through this study, we aimed to provide an accurate image of the methodology of monitoring for thyroid dysfunction in childhood brain tumor survivors. Conclusion: Given the fact that the probability of developing thyroid dysfunction in the pediatric population treated for brain tumors is not rare, we recommend that childhood brain tumor survivors be monitored for iatrogenic thyroid disease, in order to provide early diagnosis and treatment. |
| first_indexed | 2024-04-11T13:36:21Z |
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| id | doaj.art-4e7609d9d14246749e287648c70a99e1 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-04-11T13:36:21Z |
| publishDate | 2020-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-4e7609d9d14246749e287648c70a99e12022-12-22T04:21:28ZengMDPI AGDiagnostics2075-44182020-03-0110314210.3390/diagnostics10030142diagnostics10030142Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-NapocaMaria Margareta Cosnarovici0Andra Piciu1Eduard-Alexandru Bonci2Marius-Ioan Bădan3Claudiu-Iulian Bădulescu4Andreea-Ioana Stefan5Alexandru Mester6Rodica Cosnarovici7Maria-Iulia Larg8Department of Medical Oncology Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Medical Oncology Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Surgical Oncology Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Anatomy and Pathology Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Anatomy and Pathology Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania2nd Pediatric Departament Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Oral Health Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaDepartment of Pediatric Oncology “Prof.Dr.IonChiricuță”, Institute of Oncology, 400012 Cluj-Napoca; RomaniaPhD School Iuliu Hațieganu, University of Medicine and Pharmacy, 400012 Cluj-Napoca, RomaniaAim of study: The purpose of the study was to evaluate the association of thyroid dysfunction occurring in pediatric patients treated for brain tumors. Patients and methods: A total of 255 patients with brain tumors were treated between 2001 and 2018 at the “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca. Due to a minimum follow-up of 4 years, we studied 184 out of the 255 patients. The cohort included 69 girls (37.5%) and 109 boys (62.5%), with a median age of 8.4 years. The evaluated tumors included medulloblastomas (47 patients), astrocytomas (44 patients), ependymomas (22 patients), gliomas (20 patients), germ cell tumors (12 patients), primitive neuroectodermal tumors (4 patients), as well as other types of tumors (15 patients); in 20 of the cases, biopsy could not be performed. Results: There was a 60% overall survival rate; among the 120 surviving patients, 11 (9.1%) were diagnosed with iatrogenic thyroid disease. We observed an important number of iatrogenic thyroid disease cases in this group of patients, thus revealing the importance of long-term thyroid function evaluation in all children who finalized their treatment for brain tumors. Through this study, we aimed to provide an accurate image of the methodology of monitoring for thyroid dysfunction in childhood brain tumor survivors. Conclusion: Given the fact that the probability of developing thyroid dysfunction in the pediatric population treated for brain tumors is not rare, we recommend that childhood brain tumor survivors be monitored for iatrogenic thyroid disease, in order to provide early diagnosis and treatment.https://www.mdpi.com/2075-4418/10/3/142childrenthyroid dysfunctionbrain tumorsfollow-up |
| spellingShingle | Maria Margareta Cosnarovici Andra Piciu Eduard-Alexandru Bonci Marius-Ioan Bădan Claudiu-Iulian Bădulescu Andreea-Ioana Stefan Alexandru Mester Rodica Cosnarovici Maria-Iulia Larg Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca Diagnostics children thyroid dysfunction brain tumors follow-up |
| title | Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca |
| title_full | Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca |
| title_fullStr | Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca |
| title_full_unstemmed | Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca |
| title_short | Post-Treatment Thyroid Diseases in Children with Brain Tumors: A Single-Center Experience at “Prof. Dr. Ion Chiricuță” Institute of Oncology, Cluj-Napoca |
| title_sort | post treatment thyroid diseases in children with brain tumors a single center experience at prof dr ion chiricuta institute of oncology cluj napoca |
| topic | children thyroid dysfunction brain tumors follow-up |
| url | https://www.mdpi.com/2075-4418/10/3/142 |
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