Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based Study
Aging is accompanied by changes in the quantity and quality of sleep. Obstructive sleep apnea (OSA) is also more prevalent in the older population. Although severe OSA has been linked to a higher risk of cardiovascular disease regardless of adult age, clinical consequences of mild-to-moderate OSA in...
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| Format: | Article |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.802554/full |
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| author | Mayra dos Santos Silva Dalva Poyares Luciana Oliveira Silva Ksdy M. Souza Monica L. Andersen Maurice M. Ohayon Sergio Tufik Ronaldo D. Piovezan |
| author_facet | Mayra dos Santos Silva Dalva Poyares Luciana Oliveira Silva Ksdy M. Souza Monica L. Andersen Maurice M. Ohayon Sergio Tufik Ronaldo D. Piovezan |
| author_sort | Mayra dos Santos Silva |
| collection | DOAJ |
| description | Aging is accompanied by changes in the quantity and quality of sleep. Obstructive sleep apnea (OSA) is also more prevalent in the older population. Although severe OSA has been linked to a higher risk of cardiovascular disease regardless of adult age, clinical consequences of mild-to-moderate OSA in the older adults are still uncertain.ObjectivesTo investigate the relationships between severity and metabolic, cognitive, and functional characteristics in community-dwelling older adults from a representative sample of the city of São Paulo.MethodsIn total, 199 participants of the first follow-up of the São Paulo Epidemiologic Sleep Study (EPISONO, São Paulo, Brazil) >60 years were cross-sectionally assessed through questionnaires, physical evaluations, laboratory tests, and full in-lab polysomnography (PSG). Three groups according to the OSA severity were compared according to sociodemographic characteristics, anthropometric measures, PSG parameters, the frequency of comorbidities, and the use of medications.ResultsParticipants' age ranged from 60 to 87 years with a mean of 70.02 ± 7.31, 59.8% female. In the univariate analysis, body mass index (BMI, kg/m2) (p = 0.049) and waist circumference (p = 0.005) were significantly higher in the participants with moderate OSA, but not among those with severe OSA. Participants with severe OSA had a higher arousal index (p = 0.007). Multivariate analysis showed that severe OSA was significantly associated with hypertension (p = 0.005), heart diseases (p = 0.025), and the use of two or more medications (p = 0.035).ConclusionIn a population-based study, severe, but not mild-to-moderate, OSA in older adults was associated with hypertension and the use of more medications. As age advances, anthropometric indicators of obesity may not increase the risk of severe OSA. |
| first_indexed | 2024-04-13T03:42:25Z |
| format | Article |
| id | doaj.art-4e76c1844745403583c43dd52d8bf8f6 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-13T03:42:25Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neurology |
| spelling | doaj.art-4e76c1844745403583c43dd52d8bf8f62022-12-22T03:04:07ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-05-011310.3389/fneur.2022.802554802554Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based StudyMayra dos Santos Silva0Dalva Poyares1Luciana Oliveira Silva2Ksdy M. Souza3Monica L. Andersen4Maurice M. Ohayon5Sergio Tufik6Ronaldo D. Piovezan7Department of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilPsych/Public Mental Health and Population Sciences, Stanford University, Stanford, CA, United StatesDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilDepartment of Psychobiology, Universidade Federal de São Paulo, São Paulo, BrazilAging is accompanied by changes in the quantity and quality of sleep. Obstructive sleep apnea (OSA) is also more prevalent in the older population. Although severe OSA has been linked to a higher risk of cardiovascular disease regardless of adult age, clinical consequences of mild-to-moderate OSA in the older adults are still uncertain.ObjectivesTo investigate the relationships between severity and metabolic, cognitive, and functional characteristics in community-dwelling older adults from a representative sample of the city of São Paulo.MethodsIn total, 199 participants of the first follow-up of the São Paulo Epidemiologic Sleep Study (EPISONO, São Paulo, Brazil) >60 years were cross-sectionally assessed through questionnaires, physical evaluations, laboratory tests, and full in-lab polysomnography (PSG). Three groups according to the OSA severity were compared according to sociodemographic characteristics, anthropometric measures, PSG parameters, the frequency of comorbidities, and the use of medications.ResultsParticipants' age ranged from 60 to 87 years with a mean of 70.02 ± 7.31, 59.8% female. In the univariate analysis, body mass index (BMI, kg/m2) (p = 0.049) and waist circumference (p = 0.005) were significantly higher in the participants with moderate OSA, but not among those with severe OSA. Participants with severe OSA had a higher arousal index (p = 0.007). Multivariate analysis showed that severe OSA was significantly associated with hypertension (p = 0.005), heart diseases (p = 0.025), and the use of two or more medications (p = 0.035).ConclusionIn a population-based study, severe, but not mild-to-moderate, OSA in older adults was associated with hypertension and the use of more medications. As age advances, anthropometric indicators of obesity may not increase the risk of severe OSA.https://www.frontiersin.org/articles/10.3389/fneur.2022.802554/fullsleep apneaagingolder adultshypertensionbody mas index |
| spellingShingle | Mayra dos Santos Silva Dalva Poyares Luciana Oliveira Silva Ksdy M. Souza Monica L. Andersen Maurice M. Ohayon Sergio Tufik Ronaldo D. Piovezan Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based Study Frontiers in Neurology sleep apnea aging older adults hypertension body mas index |
| title | Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based Study |
| title_full | Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based Study |
| title_fullStr | Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based Study |
| title_full_unstemmed | Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based Study |
| title_short | Associations of the Severity of Obstructive Sleep Apnea With Age-Related Comorbidities: A Population-Based Study |
| title_sort | associations of the severity of obstructive sleep apnea with age related comorbidities a population based study |
| topic | sleep apnea aging older adults hypertension body mas index |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.802554/full |
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