Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats
We investigated the effect of etoricoxib, a selective cyclooxygenase-2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhibitor, on experimental periodontitis, and compared their gastrointestinal side effects. A ligature was placed around the second upper left molars of female Wistar ra...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2007-01-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100015 |
| _version_ | 1811310227496108032 |
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| author | M.C.F. Azoubel A.M.A. Menezes D. Bezerra R.B. Oriá R.A. Ribeiro G.A.C. Brito |
| author_facet | M.C.F. Azoubel A.M.A. Menezes D. Bezerra R.B. Oriá R.A. Ribeiro G.A.C. Brito |
| author_sort | M.C.F. Azoubel |
| collection | DOAJ |
| description | We investigated the effect of etoricoxib, a selective cyclooxygenase-2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhibitor, on experimental periodontitis, and compared their gastrointestinal side effects. A ligature was placed around the second upper left molars of female Wistar rats (160 to 200 g). Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day. The weight and survival rate were monitored. Alveolar bone loss (ABL) was measured as the sum of distances between the cusp tips and the alveolar bone. The gastric mucosa was examined macroscopically and the periodontium and gastric and intestinal mucosa were examined by histopathology. The ongoing ABL was significantly inhibited (P < 0.05) by 3 and 9 mg/kg etoricoxib and by indomethacin: control = 4.08 ± 0.47 mm; etoricoxib (3 mg/kg) = 1.89 ± 0.26 mm; etoricoxib (9 mg/kg) = 1.02 ± 0.14 mm; indomethacin = 0.64 ± 0.15 mm. Histopathology of periodontium showed that etoricoxib and indomethacin reduced inflammatory cell infiltration, ABL, and cementum and collagen fiber destruction. Macroscopic and histopathological analysis of gastric and intestinal mucosa demonstrated that etoricoxib induces less damage than indomethacin. Animals that received indomethacin presented weight loss starting on the 7th day, and higher mortality rate (58.3%) compared to etoricoxib (0%). Treatment with etoricoxib, even starting when ABL is detected, reduces inflammation and cementum and bone resorption, with fewer gastrointestinal side effects. |
| first_indexed | 2024-04-13T09:54:44Z |
| format | Article |
| id | doaj.art-4e7870a622584fd0bfae62b7c84c1843 |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-04-13T09:54:44Z |
| publishDate | 2007-01-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-4e7870a622584fd0bfae62b7c84c18432022-12-22T02:51:27ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2007-01-01401117125Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in ratsM.C.F. AzoubelA.M.A. MenezesD. BezerraR.B. OriáR.A. RibeiroG.A.C. BritoWe investigated the effect of etoricoxib, a selective cyclooxygenase-2 inhibitor, and indomethacin, a non-selective cyclooxygenase inhibitor, on experimental periodontitis, and compared their gastrointestinal side effects. A ligature was placed around the second upper left molars of female Wistar rats (160 to 200 g). Animals (6 per group) were treated daily with oral doses of 3 or 9 mg/kg etoricoxib, 5 mg/kg indomethacin, or 0.2 mL saline, starting 5 days after the induction of periodontitis, when bone resorption was detected, until the sacrifice on the 11th day. The weight and survival rate were monitored. Alveolar bone loss (ABL) was measured as the sum of distances between the cusp tips and the alveolar bone. The gastric mucosa was examined macroscopically and the periodontium and gastric and intestinal mucosa were examined by histopathology. The ongoing ABL was significantly inhibited (P < 0.05) by 3 and 9 mg/kg etoricoxib and by indomethacin: control = 4.08 ± 0.47 mm; etoricoxib (3 mg/kg) = 1.89 ± 0.26 mm; etoricoxib (9 mg/kg) = 1.02 ± 0.14 mm; indomethacin = 0.64 ± 0.15 mm. Histopathology of periodontium showed that etoricoxib and indomethacin reduced inflammatory cell infiltration, ABL, and cementum and collagen fiber destruction. Macroscopic and histopathological analysis of gastric and intestinal mucosa demonstrated that etoricoxib induces less damage than indomethacin. Animals that received indomethacin presented weight loss starting on the 7th day, and higher mortality rate (58.3%) compared to etoricoxib (0%). Treatment with etoricoxib, even starting when ABL is detected, reduces inflammation and cementum and bone resorption, with fewer gastrointestinal side effects.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100015Alveolar bone lossInflammationPeriodontitisCyclooxygenase inhibitorsEtoricoxibIndomethacin |
| spellingShingle | M.C.F. Azoubel A.M.A. Menezes D. Bezerra R.B. Oriá R.A. Ribeiro G.A.C. Brito Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats Brazilian Journal of Medical and Biological Research Alveolar bone loss Inflammation Periodontitis Cyclooxygenase inhibitors Etoricoxib Indomethacin |
| title | Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats |
| title_full | Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats |
| title_fullStr | Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats |
| title_full_unstemmed | Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats |
| title_short | Comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats |
| title_sort | comparison of etoricoxib and indomethacin for the treatment of experimental periodontitis in rats |
| topic | Alveolar bone loss Inflammation Periodontitis Cyclooxygenase inhibitors Etoricoxib Indomethacin |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000100015 |
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