UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin

UCHL3 promotes hepatocellular carcinoma cell migration by de-ubiquitinating and stabilizing Vimentin

BackgroundHepatocellular carcinoma (HCC) is a common malignant tumor associated with a poor prognosis. Ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) has been reported to promote diverse tumors, but little is known about its role in HCC.MethodsExpression levels of UCHL3 in Huh7 and Hep3B cells wer...

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Bibliographic Details
Main Authors: Qiancheng Ma, Qiliang Lu, Xiangxiang Lei, Jie Zhao, Wen Sun, Jun Wang, Qing Zhu, Dongsheng Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Oncology
Subjects:
HCC
UCHL3
Vimentin
de-ubiquitination
migration
cancer stem cells
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1088475/full

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