Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies
Pregnancy toxemia is a nutritional metabolic disease during late gestation in small ruminants. The condition is characterized by disorders in carbohydrate and fat metabolism. Obese and multiparous ewes are particularly susceptible to pregnancy toxemia, which may lead to maternal death, abortion, or...
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MDPI AG
2023-01-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/13/2/149 |
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| author | Xiaoyu Ji Ning Liu Yuqin Wang Ke Ding Shucheng Huang Cai Zhang |
| author_facet | Xiaoyu Ji Ning Liu Yuqin Wang Ke Ding Shucheng Huang Cai Zhang |
| author_sort | Xiaoyu Ji |
| collection | DOAJ |
| description | Pregnancy toxemia is a nutritional metabolic disease during late gestation in small ruminants. The condition is characterized by disorders in carbohydrate and fat metabolism. Obese and multiparous ewes are particularly susceptible to pregnancy toxemia, which may lead to maternal death, abortion, or premature birth. Highly productive multiparous meat ewes are major breeding animals, which has led to an increased incidence of the disease. However, the pathogenesis of pregnancy toxemia remains unclear and adequate disease prevention and treatment strategies are absent. Investigating the pathogenesis of pregnancy toxemia, especially the metabolic pathways of hepatic lipids, is key to an improved understanding of the condition. This review provides a snapshot of the genes that are associated with lipid metabolism in the ovine liver, including genes involved in fatty acid oxidation, acetyl coenzyme metabolism, and triglyceride synthesis; describes the interrelationships between these genes; and summarizes the diagnosis, prevention, and treatment of pregnancy toxemia. |
| first_indexed | 2024-03-11T08:26:08Z |
| format | Article |
| id | doaj.art-4e7a8e4b08c14d35bfc705563e51aea1 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-11T08:26:08Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-4e7a8e4b08c14d35bfc705563e51aea12023-11-16T22:03:35ZengMDPI AGMetabolites2218-19892023-01-0113214910.3390/metabo13020149Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management StrategiesXiaoyu Ji0Ning Liu1Yuqin Wang2Ke Ding3Shucheng Huang4Cai Zhang5College of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, ChinaCollege of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450002, ChinaCollege of Animal Science and Technology, Henan University of Science and Technology, Luoyang 471023, ChinaPregnancy toxemia is a nutritional metabolic disease during late gestation in small ruminants. The condition is characterized by disorders in carbohydrate and fat metabolism. Obese and multiparous ewes are particularly susceptible to pregnancy toxemia, which may lead to maternal death, abortion, or premature birth. Highly productive multiparous meat ewes are major breeding animals, which has led to an increased incidence of the disease. However, the pathogenesis of pregnancy toxemia remains unclear and adequate disease prevention and treatment strategies are absent. Investigating the pathogenesis of pregnancy toxemia, especially the metabolic pathways of hepatic lipids, is key to an improved understanding of the condition. This review provides a snapshot of the genes that are associated with lipid metabolism in the ovine liver, including genes involved in fatty acid oxidation, acetyl coenzyme metabolism, and triglyceride synthesis; describes the interrelationships between these genes; and summarizes the diagnosis, prevention, and treatment of pregnancy toxemia.https://www.mdpi.com/2218-1989/13/2/149pregnancy toxemianutritional metabolic diseaselipid metabolismdiagnosissmall ruminants |
| spellingShingle | Xiaoyu Ji Ning Liu Yuqin Wang Ke Ding Shucheng Huang Cai Zhang Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies Metabolites pregnancy toxemia nutritional metabolic disease lipid metabolism diagnosis small ruminants |
| title | Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies |
| title_full | Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies |
| title_fullStr | Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies |
| title_full_unstemmed | Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies |
| title_short | Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies |
| title_sort | pregnancy toxemia in ewes a review of molecular metabolic mechanisms and management strategies |
| topic | pregnancy toxemia nutritional metabolic disease lipid metabolism diagnosis small ruminants |
| url | https://www.mdpi.com/2218-1989/13/2/149 |
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