Influence of urinary tract infection on infiltration of bladder tumors by immune cells
Background. Tumor-infiltrating immune cells have been associated with outcomes in various tumors, including urothelial carcinoma. It is supposed that the accompanying urinary infection can influence the local immunity activity, leading to changes of features of bladder tumor course. Objective of the...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2014-06-01
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| Series: | Морфологія |
| Subjects: | |
| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2014-08-02/14mrnpik.pdf |
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| author | Molchanov R.N. Shponka I.S. |
| author_facet | Molchanov R.N. Shponka I.S. |
| author_sort | Molchanov R.N. |
| collection | DOAJ |
| description | Background. Tumor-infiltrating immune cells have been associated with outcomes in various tumors, including urothelial carcinoma. It is supposed that the accompanying urinary infection can influence the local immunity activity, leading to changes of features of bladder tumor course. Objective of the research was studying of the urinary tract infection influence on an infiltration of a tumor with immune cells. Methods. Immunohistochemical research of CD3+, CD4+, CD8+, CD20+, CD68+ markers expression in tumor specimens, received from 44 patients with a bladder cancer was made. The patients were divided on two groups in conformity with absence (I) or presence (II) of urinary tract infection. Results. It is established that in group I specimens 96,0±4,9 % СD3+, 98,6±0,9% СD4+, 82,6±12,6% CD8+ and 78,7±9,29% CD68+ immunocytes were revealed in stromal compartment of tumor, while in group II - 97,0±2,1%, 98,3±0,8% и 84,4±13,1% and 81,9±6,2% respectively. The difference was not statistically significant (p>0,05). СD20+ cells were revealed only in stromal compartment of tumor, and they formed foci in group II specimens (p>0,05). Conclusion. T-cells are prevailing among immunocytes, infiltrating a superficial bladder cancer. In stromal compartment prevail СD4+, while in epithelial - СD8+ T-lymphocytes and СD68+ macrophages. The accompanying urinary tract infection had no statistically significant influence on intensity and selectivity of infiltration of a tissue of tumor with СD3+, СD4+, CD8+, СD68+ immunocytes. The significant augmentation of infiltration of the stromal compartment of tumor with СD20+ B-lymphocytes with formation of lymphatic follicles in patients with urinary tract infection, can be an element of a chronic interstitial inflammation.
Citation: Molchanov RN, Shponka IS. [Influence of urinary tract infection on infiltration of bladder tumors by immune cells]. Morphologia. 2014;8(2):37-44. Russian. |
| first_indexed | 2024-12-12T10:58:06Z |
| format | Article |
| id | doaj.art-4e7afc43d527497c84301699e7dde7f6 |
| institution | Directory Open Access Journal |
| issn | 1997-9665 1997-9665 |
| language | Russian |
| last_indexed | 2024-12-12T10:58:06Z |
| publishDate | 2014-06-01 |
| publisher | Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
| record_format | Article |
| series | Морфологія |
| spelling | doaj.art-4e7afc43d527497c84301699e7dde7f62022-12-22T00:26:36ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical AcademyМорфологія1997-96651997-96652014-06-01823744Influence of urinary tract infection on infiltration of bladder tumors by immune cellsMolchanov R.N.0Shponka I.S.1State establishment “Dnipropetrovsk medical academy of Health Ministry of Ukraine”State establishment “Dnipropetrovsk medical academy of Health Ministry of Ukraine”Background. Tumor-infiltrating immune cells have been associated with outcomes in various tumors, including urothelial carcinoma. It is supposed that the accompanying urinary infection can influence the local immunity activity, leading to changes of features of bladder tumor course. Objective of the research was studying of the urinary tract infection influence on an infiltration of a tumor with immune cells. Methods. Immunohistochemical research of CD3+, CD4+, CD8+, CD20+, CD68+ markers expression in tumor specimens, received from 44 patients with a bladder cancer was made. The patients were divided on two groups in conformity with absence (I) or presence (II) of urinary tract infection. Results. It is established that in group I specimens 96,0±4,9 % СD3+, 98,6±0,9% СD4+, 82,6±12,6% CD8+ and 78,7±9,29% CD68+ immunocytes were revealed in stromal compartment of tumor, while in group II - 97,0±2,1%, 98,3±0,8% и 84,4±13,1% and 81,9±6,2% respectively. The difference was not statistically significant (p>0,05). СD20+ cells were revealed only in stromal compartment of tumor, and they formed foci in group II specimens (p>0,05). Conclusion. T-cells are prevailing among immunocytes, infiltrating a superficial bladder cancer. In stromal compartment prevail СD4+, while in epithelial - СD8+ T-lymphocytes and СD68+ macrophages. The accompanying urinary tract infection had no statistically significant influence on intensity and selectivity of infiltration of a tissue of tumor with СD3+, СD4+, CD8+, СD68+ immunocytes. The significant augmentation of infiltration of the stromal compartment of tumor with СD20+ B-lymphocytes with formation of lymphatic follicles in patients with urinary tract infection, can be an element of a chronic interstitial inflammation. Citation: Molchanov RN, Shponka IS. [Influence of urinary tract infection on infiltration of bladder tumors by immune cells]. Morphologia. 2014;8(2):37-44. Russian.http://www.morphology.dp.ua/_pub/MORPHO-2014-08-02/14mrnpik.pdfbladder tumorinflammationtumor infiltrating immunocytes |
| spellingShingle | Molchanov R.N. Shponka I.S. Influence of urinary tract infection on infiltration of bladder tumors by immune cells Морфологія bladder tumor inflammation tumor infiltrating immunocytes |
| title | Influence of urinary tract infection on infiltration of bladder tumors by immune cells |
| title_full | Influence of urinary tract infection on infiltration of bladder tumors by immune cells |
| title_fullStr | Influence of urinary tract infection on infiltration of bladder tumors by immune cells |
| title_full_unstemmed | Influence of urinary tract infection on infiltration of bladder tumors by immune cells |
| title_short | Influence of urinary tract infection on infiltration of bladder tumors by immune cells |
| title_sort | influence of urinary tract infection on infiltration of bladder tumors by immune cells |
| topic | bladder tumor inflammation tumor infiltrating immunocytes |
| url | http://www.morphology.dp.ua/_pub/MORPHO-2014-08-02/14mrnpik.pdf |
| work_keys_str_mv | AT molchanovrn influenceofurinarytractinfectiononinfiltrationofbladdertumorsbyimmunecells AT shponkais influenceofurinarytractinfectiononinfiltrationofbladdertumorsbyimmunecells |