Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead
Neural oscillations have been categorized into various frequency bands that are mechanistically associated with different cognitive functions. Specifically, the gamma band frequency is widely implicated to be involved in a wide range of cognitive processes. As such, decreased gamma oscillation has b...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-04-01
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| Series: | Frontiers in Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnint.2023.1146687/full |
| _version_ | 1797845597956341760 |
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| author | Prangya Parimita Sahu Prangya Parimita Sahu Philip Tseng Philip Tseng |
| author_facet | Prangya Parimita Sahu Prangya Parimita Sahu Philip Tseng Philip Tseng |
| author_sort | Prangya Parimita Sahu |
| collection | DOAJ |
| description | Neural oscillations have been categorized into various frequency bands that are mechanistically associated with different cognitive functions. Specifically, the gamma band frequency is widely implicated to be involved in a wide range of cognitive processes. As such, decreased gamma oscillation has been associated with cognitive declines in neurological diseases, such as memory dysfunction in Alzheimer’s disease (AD). Recently, studies have attempted to artificially induce gamma oscillations by using 40 Hz sensory entrainment stimulation. These studies reported attenuation of amyloid load, hyper-phosphorylation of tau protein, and improvement in overall cognition in both AD patients and mouse models. In this review, we discuss the advancements in the use of sensory stimulation in animal models of AD and as a therapeutic strategy in AD patients. We also discuss future opportunities, as well as challenges, for using such strategies in other neurodegenerative and neuropsychiatric diseases. |
| first_indexed | 2024-04-09T17:41:36Z |
| format | Article |
| id | doaj.art-4e7b1b5fd7cc4ab2802928acf3aa6e4c |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-04-09T17:41:36Z |
| publishDate | 2023-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-4e7b1b5fd7cc4ab2802928acf3aa6e4c2023-04-17T04:28:26ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452023-04-011710.3389/fnint.2023.11466871146687Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges aheadPrangya Parimita Sahu0Prangya Parimita Sahu1Philip Tseng2Philip Tseng3Graduate Institute of Mind, Brain and Consciousness, Taipei Medical University, Taipei, TaiwanBrain and Consciousness Research Center, Shuang Ho Hospital, Taipei Medical University, Taipei, TaiwanCross College Elite Program, National Cheng Kung University, Tainan, TaiwanResearch Center for Mind, Brain and Learning, National Chengchi University, Taipei, TaiwanNeural oscillations have been categorized into various frequency bands that are mechanistically associated with different cognitive functions. Specifically, the gamma band frequency is widely implicated to be involved in a wide range of cognitive processes. As such, decreased gamma oscillation has been associated with cognitive declines in neurological diseases, such as memory dysfunction in Alzheimer’s disease (AD). Recently, studies have attempted to artificially induce gamma oscillations by using 40 Hz sensory entrainment stimulation. These studies reported attenuation of amyloid load, hyper-phosphorylation of tau protein, and improvement in overall cognition in both AD patients and mouse models. In this review, we discuss the advancements in the use of sensory stimulation in animal models of AD and as a therapeutic strategy in AD patients. We also discuss future opportunities, as well as challenges, for using such strategies in other neurodegenerative and neuropsychiatric diseases.https://www.frontiersin.org/articles/10.3389/fnint.2023.1146687/fullsensory entrainmentbrain stimulation40 Hz stimulationGENUSvisuoauditory stimulation |
| spellingShingle | Prangya Parimita Sahu Prangya Parimita Sahu Philip Tseng Philip Tseng Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead Frontiers in Integrative Neuroscience sensory entrainment brain stimulation 40 Hz stimulation GENUS visuoauditory stimulation |
| title | Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead |
| title_full | Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead |
| title_fullStr | Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead |
| title_full_unstemmed | Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead |
| title_short | Gamma sensory entrainment for cognitive improvement in neurodegenerative diseases: opportunities and challenges ahead |
| title_sort | gamma sensory entrainment for cognitive improvement in neurodegenerative diseases opportunities and challenges ahead |
| topic | sensory entrainment brain stimulation 40 Hz stimulation GENUS visuoauditory stimulation |
| url | https://www.frontiersin.org/articles/10.3389/fnint.2023.1146687/full |
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