Nucleosome-directed replication origin licensing independent of a consensus DNA sequence
Most eukaryotes do not use a consensus DNA sequence as binding sites for the origin recognition complex (ORC) to initiate DNA replication, however budding yeast do. Here the authors show S. cerevisiae ORC can bind nucleosomes near nucleosome-free regions and recruit replicative helicases to form a p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32657-7 |
| _version_ | 1817998877147529216 |
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| author | Sai Li Michael R. Wasserman Olga Yurieva Lu Bai Michael E. O’Donnell Shixin Liu |
| author_facet | Sai Li Michael R. Wasserman Olga Yurieva Lu Bai Michael E. O’Donnell Shixin Liu |
| author_sort | Sai Li |
| collection | DOAJ |
| description | Most eukaryotes do not use a consensus DNA sequence as binding sites for the origin recognition complex (ORC) to initiate DNA replication, however budding yeast do. Here the authors show S. cerevisiae ORC can bind nucleosomes near nucleosome-free regions and recruit replicative helicases to form a pre-replication complex independent of the DNA sequence. |
| first_indexed | 2024-04-14T03:00:09Z |
| format | Article |
| id | doaj.art-4e7f00dcc6604bff9c1adf9f7d3dc6ca |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T03:00:09Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4e7f00dcc6604bff9c1adf9f7d3dc6ca2022-12-22T02:15:56ZengNature PortfolioNature Communications2041-17232022-08-0113111510.1038/s41467-022-32657-7Nucleosome-directed replication origin licensing independent of a consensus DNA sequenceSai Li0Michael R. Wasserman1Olga Yurieva2Lu Bai3Michael E. O’Donnell4Shixin Liu5Laboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller UniversityLaboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller UniversityLaboratory of DNA Replication, The Rockefeller UniversityCenter for Eukaryotic Gene Regulation, The Pennsylvania State UniversityLaboratory of DNA Replication, The Rockefeller UniversityLaboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller UniversityMost eukaryotes do not use a consensus DNA sequence as binding sites for the origin recognition complex (ORC) to initiate DNA replication, however budding yeast do. Here the authors show S. cerevisiae ORC can bind nucleosomes near nucleosome-free regions and recruit replicative helicases to form a pre-replication complex independent of the DNA sequence.https://doi.org/10.1038/s41467-022-32657-7 |
| spellingShingle | Sai Li Michael R. Wasserman Olga Yurieva Lu Bai Michael E. O’Donnell Shixin Liu Nucleosome-directed replication origin licensing independent of a consensus DNA sequence Nature Communications |
| title | Nucleosome-directed replication origin licensing independent of a consensus DNA sequence |
| title_full | Nucleosome-directed replication origin licensing independent of a consensus DNA sequence |
| title_fullStr | Nucleosome-directed replication origin licensing independent of a consensus DNA sequence |
| title_full_unstemmed | Nucleosome-directed replication origin licensing independent of a consensus DNA sequence |
| title_short | Nucleosome-directed replication origin licensing independent of a consensus DNA sequence |
| title_sort | nucleosome directed replication origin licensing independent of a consensus dna sequence |
| url | https://doi.org/10.1038/s41467-022-32657-7 |
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