Inhibition of PTP1B Promotes M2 Polarization via MicroRNA-26a/MKP1 Signaling Pathway in Murine Macrophages

Inhibition of PTP1B Promotes M2 Polarization via MicroRNA-26a/MKP1 Signaling Pathway in Murine Macrophages

Sepsis is a life-threatening condition that often occurs in the intensive care unit. The excessive activation of the host's immune system at early stages contributes to multiple organ damage. Mitogen-activated protein kinase phosphatase-1 (MKP1) exerts an important effect on the inflammatory pr...

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Bibliographic Details
Main Authors: Xiaolong Xu, Xuerui Wang, Yuhong Guo, Yunjing Bai, Shasha He, Ning Wang, Yan Lin, Marc Fisher, Qingquan Liu, Yongming Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
sepsis
PTP1B
MKP1
miR-26a
murine macrophage
polarization
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01930/full

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