Lymph-Venous Anastomosis for Breast Cancer-Related Lymphoedema after Docetaxel-Based Chemotherapy
Docetaxel-based chemotherapy, which is administered before or after axillary lymph node dissection (ALND) in breast cancer patients with positive axillary lymph nodes, is reported as an independent risk factor for development of breast cancer-related lymphoedema (BCRL). Severe hardening of the soft...
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| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/11/5/1409 |
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| author | Yuma Fuse Ryo Karakawa Tomoyuki Yano Hidehiko Yoshimatsu |
| author_facet | Yuma Fuse Ryo Karakawa Tomoyuki Yano Hidehiko Yoshimatsu |
| author_sort | Yuma Fuse |
| collection | DOAJ |
| description | Docetaxel-based chemotherapy, which is administered before or after axillary lymph node dissection (ALND) in breast cancer patients with positive axillary lymph nodes, is reported as an independent risk factor for development of breast cancer-related lymphoedema (BCRL). Severe hardening of the soft tissue, which is a typical manifestation of BCRL with a history of docetaxel-based chemotherapy, has been considered a contraindication for lymph-venous anastomosis (LVA). This study aimed to evaluate the efficacy of LVA for BCRL with a history of the use of docetaxel. Twenty-six consecutive BCRL patients who underwent LVA were reviewed retrospectively. All patients underwent ALND. Amongst 23 patients who had chemotherapy for breast cancer, docetaxel-based chemotherapy was administered in 12 patients. The postoperative change of the limb circumferences and the improvement of subjective symptoms were assessed. Overall, patients showed improvements of the limb circumferences at the wrist, the elbow, and 5 cm above and below the elbow. There were no statistical differences of the postoperative changes of the circumferences between the docetaxel-administered and non-administered groups (0.25% vs. 2.8% at 5 cm above the elbow (<i>p</i> = 0.23), −0.4% vs. 0.7% at 5 cm below the elbow (<i>p</i> = 0.56), and 2.5% vs. 2.5 % at the wrist (<i>p</i> = 0.82)). LVA is comparably effective for lymphedematous patients who had undergone docetaxel-based chemotherapy before or after ALND. |
| first_indexed | 2024-03-09T20:33:56Z |
| format | Article |
| id | doaj.art-4e806dc07057454abe4ad3f8e753ef0d |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-09T20:33:56Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-4e806dc07057454abe4ad3f8e753ef0d2023-11-23T23:15:28ZengMDPI AGJournal of Clinical Medicine2077-03832022-03-01115140910.3390/jcm11051409Lymph-Venous Anastomosis for Breast Cancer-Related Lymphoedema after Docetaxel-Based ChemotherapyYuma Fuse0Ryo Karakawa1Tomoyuki Yano2Hidehiko Yoshimatsu3Department of Plastic and Reconstructive Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo 135-8550, JapanDepartment of Plastic and Reconstructive Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo 135-8550, JapanDepartment of Plastic and Reconstructive Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo 135-8550, JapanDepartment of Plastic and Reconstructive Surgery, Cancer Institute Hospital of the Japanese Foundation for Cancer Research, Tokyo 135-8550, JapanDocetaxel-based chemotherapy, which is administered before or after axillary lymph node dissection (ALND) in breast cancer patients with positive axillary lymph nodes, is reported as an independent risk factor for development of breast cancer-related lymphoedema (BCRL). Severe hardening of the soft tissue, which is a typical manifestation of BCRL with a history of docetaxel-based chemotherapy, has been considered a contraindication for lymph-venous anastomosis (LVA). This study aimed to evaluate the efficacy of LVA for BCRL with a history of the use of docetaxel. Twenty-six consecutive BCRL patients who underwent LVA were reviewed retrospectively. All patients underwent ALND. Amongst 23 patients who had chemotherapy for breast cancer, docetaxel-based chemotherapy was administered in 12 patients. The postoperative change of the limb circumferences and the improvement of subjective symptoms were assessed. Overall, patients showed improvements of the limb circumferences at the wrist, the elbow, and 5 cm above and below the elbow. There were no statistical differences of the postoperative changes of the circumferences between the docetaxel-administered and non-administered groups (0.25% vs. 2.8% at 5 cm above the elbow (<i>p</i> = 0.23), −0.4% vs. 0.7% at 5 cm below the elbow (<i>p</i> = 0.56), and 2.5% vs. 2.5 % at the wrist (<i>p</i> = 0.82)). LVA is comparably effective for lymphedematous patients who had undergone docetaxel-based chemotherapy before or after ALND.https://www.mdpi.com/2077-0383/11/5/1409breast cancer-related lymphedemalymph-venous anastomosisdocetaxel-based chemotherapy |
| spellingShingle | Yuma Fuse Ryo Karakawa Tomoyuki Yano Hidehiko Yoshimatsu Lymph-Venous Anastomosis for Breast Cancer-Related Lymphoedema after Docetaxel-Based Chemotherapy Journal of Clinical Medicine breast cancer-related lymphedema lymph-venous anastomosis docetaxel-based chemotherapy |
| title | Lymph-Venous Anastomosis for Breast Cancer-Related Lymphoedema after Docetaxel-Based Chemotherapy |
| title_full | Lymph-Venous Anastomosis for Breast Cancer-Related Lymphoedema after Docetaxel-Based Chemotherapy |
| title_fullStr | Lymph-Venous Anastomosis for Breast Cancer-Related Lymphoedema after Docetaxel-Based Chemotherapy |
| title_full_unstemmed | Lymph-Venous Anastomosis for Breast Cancer-Related Lymphoedema after Docetaxel-Based Chemotherapy |
| title_short | Lymph-Venous Anastomosis for Breast Cancer-Related Lymphoedema after Docetaxel-Based Chemotherapy |
| title_sort | lymph venous anastomosis for breast cancer related lymphoedema after docetaxel based chemotherapy |
| topic | breast cancer-related lymphedema lymph-venous anastomosis docetaxel-based chemotherapy |
| url | https://www.mdpi.com/2077-0383/11/5/1409 |
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