Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse
Early life adversity (ELA) is associated with altered neural development and increased risk for the development of psychopathology across the lifespan. Rodent models of ELA are an important tool for investigating the possible mechanistic underpinnings of pathology development. We used a limited bedd...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Behavioral Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00167/full |
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| author | Meghan Gallo Daniel G. Shleifer Livea D. Godoy Livea D. Godoy Dayshalis Ofray Aliyah Olaniyan Talia Campbell Kevin G. Bath |
| author_facet | Meghan Gallo Daniel G. Shleifer Livea D. Godoy Livea D. Godoy Dayshalis Ofray Aliyah Olaniyan Talia Campbell Kevin G. Bath |
| author_sort | Meghan Gallo |
| collection | DOAJ |
| description | Early life adversity (ELA) is associated with altered neural development and increased risk for the development of psychopathology across the lifespan. Rodent models of ELA are an important tool for investigating the possible mechanistic underpinnings of pathology development. We used a limited bedding and nesting model (LBN) to induce stress in the dam and alter dam-pup interactions during a sensitive period in early postnatal development. The primary characteristics previously identified in this model include fragmented and unpredictable maternal care and possibly neglect. However, previous studies have not considered the effects of this manipulation over the full circadian cycle and the evolution of changes of maternal behavior throughout the duration of the manipulation. In the current study, we leverage a novel continuous video monitoring setup to unobtrusively observe and subsequently analyze maternal behaviors. Through this more in-depth analysis, we discovered that LBN dams spent more time than control dams on their nest, returned to their nest more frequently than control dams, and showed intact maternal care. Importantly, a subset of LBN dams (~40%) engaged in abusive-like kicking, a behavioral pattern not previously identified in this paradigm. Exposure to ELA and abusive-like kicking were associated with differences in risk-taking behavior in adulthood. The LBN model of ELA may drive a more complex constellation of effects on maternal behavior driving a pattern of increased dam-pup interactions and increased abuse-like kicking behavior, with unique consequences for pup outcomes. |
| first_indexed | 2024-12-21T05:50:31Z |
| format | Article |
| id | doaj.art-4e82cee8317c457bb0ae0d9c32e29472 |
| institution | Directory Open Access Journal |
| issn | 1662-5153 |
| language | English |
| last_indexed | 2024-12-21T05:50:31Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Behavioral Neuroscience |
| spelling | doaj.art-4e82cee8317c457bb0ae0d9c32e294722022-12-21T19:13:59ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-07-011310.3389/fnbeh.2019.00167464808Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and AbuseMeghan Gallo0Daniel G. Shleifer1Livea D. Godoy2Livea D. Godoy3Dayshalis Ofray4Aliyah Olaniyan5Talia Campbell6Kevin G. Bath7Department of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, United StatesDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, United StatesDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, United StatesPhysiology Department, Ribeirão Preto Medical School, University of São Paulo, São Paulo, BrazilDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, United StatesDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, United StatesDepartment of Neuroscience, Brown University, Providence, RI, United StatesDepartment of Cognitive, Linguistic, and Psychological Sciences, Brown University, Providence, RI, United StatesEarly life adversity (ELA) is associated with altered neural development and increased risk for the development of psychopathology across the lifespan. Rodent models of ELA are an important tool for investigating the possible mechanistic underpinnings of pathology development. We used a limited bedding and nesting model (LBN) to induce stress in the dam and alter dam-pup interactions during a sensitive period in early postnatal development. The primary characteristics previously identified in this model include fragmented and unpredictable maternal care and possibly neglect. However, previous studies have not considered the effects of this manipulation over the full circadian cycle and the evolution of changes of maternal behavior throughout the duration of the manipulation. In the current study, we leverage a novel continuous video monitoring setup to unobtrusively observe and subsequently analyze maternal behaviors. Through this more in-depth analysis, we discovered that LBN dams spent more time than control dams on their nest, returned to their nest more frequently than control dams, and showed intact maternal care. Importantly, a subset of LBN dams (~40%) engaged in abusive-like kicking, a behavioral pattern not previously identified in this paradigm. Exposure to ELA and abusive-like kicking were associated with differences in risk-taking behavior in adulthood. The LBN model of ELA may drive a more complex constellation of effects on maternal behavior driving a pattern of increased dam-pup interactions and increased abuse-like kicking behavior, with unique consequences for pup outcomes.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00167/fullearly life stressearly life adversitylimited beddingabusekickingmaternal care |
| spellingShingle | Meghan Gallo Daniel G. Shleifer Livea D. Godoy Livea D. Godoy Dayshalis Ofray Aliyah Olaniyan Talia Campbell Kevin G. Bath Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse Frontiers in Behavioral Neuroscience early life stress early life adversity limited bedding abuse kicking maternal care |
| title | Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse |
| title_full | Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse |
| title_fullStr | Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse |
| title_full_unstemmed | Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse |
| title_short | Limited Bedding and Nesting Induces Maternal Behavior Resembling Both Hypervigilance and Abuse |
| title_sort | limited bedding and nesting induces maternal behavior resembling both hypervigilance and abuse |
| topic | early life stress early life adversity limited bedding abuse kicking maternal care |
| url | https://www.frontiersin.org/article/10.3389/fnbeh.2019.00167/full |
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