Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine
During foetal life, the liver plays the important roles of connection and transient hematopoietic function. Foetal liver cells develop in an environment called a hematopoietic stem cell niche composed of several cell types, where stem cells can proliferate and give rise to mature blood cells. Embryo...
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-08-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/8/8/914 |
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| author | Antonella Giancotti Marco Monti Lorenzo Nevi Samira Safarikia Valentina D’Ambrosio Roberto Brunelli Cristina Pajno Sara Corno Violante Di Donato Angela Musella Michele Francesco Chiappetta Daniela Bosco Pierluigi Benedetti Panici Domenico Alvaro Vincenzo Cardinale |
| author_facet | Antonella Giancotti Marco Monti Lorenzo Nevi Samira Safarikia Valentina D’Ambrosio Roberto Brunelli Cristina Pajno Sara Corno Violante Di Donato Angela Musella Michele Francesco Chiappetta Daniela Bosco Pierluigi Benedetti Panici Domenico Alvaro Vincenzo Cardinale |
| author_sort | Antonella Giancotti |
| collection | DOAJ |
| description | During foetal life, the liver plays the important roles of connection and transient hematopoietic function. Foetal liver cells develop in an environment called a hematopoietic stem cell niche composed of several cell types, where stem cells can proliferate and give rise to mature blood cells. Embryologically, at about the third week of gestation, the liver appears, and it grows rapidly from the fifth to 10th week under WNT/β-Catenin signaling pathway stimulation, which induces hepatic progenitor cells proliferation and differentiation into hepatocytes. Development of new strategies and identification of new cell sources should represent the main aim in liver regenerative medicine and cell therapy. Cells isolated from organs with endodermal origin, like the liver, bile ducts, and pancreas, could be preferable cell sources. Furthermore, stem cells isolated from these organs could be more susceptible to differentiate into mature liver cells after transplantation with respect to stem cells isolated from organs or tissues with a different embryological origin. The foetal liver possesses unique features given the co-existence of cells having endodermal and mesenchymal origin, and it could be highly available source candidate for regenerative medicine in both the liver and pancreas. Taking into account these advantages, the foetal liver can be the highest potential and available cell source for cell therapy regarding liver diseases and diabetes. |
| first_indexed | 2024-03-12T06:19:38Z |
| format | Article |
| id | doaj.art-4e8334d130384fc7a0b910604911f4b6 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:19:38Z |
| publishDate | 2019-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4e8334d130384fc7a0b910604911f4b62023-09-03T02:19:27ZengMDPI AGCells2073-44092019-08-018891410.3390/cells8080914cells8080914Functions and the Emerging Role of the Foetal Liver into Regenerative MedicineAntonella Giancotti0Marco Monti1Lorenzo Nevi2Samira Safarikia3Valentina D’Ambrosio4Roberto Brunelli5Cristina Pajno6Sara Corno7Violante Di Donato8Angela Musella9Michele Francesco Chiappetta10Daniela Bosco11Pierluigi Benedetti Panici12Domenico Alvaro13Vincenzo Cardinale14Department of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Translation and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Translation and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Translation and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Pathological Anatomy and Cytodiagnostic, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Maternal and Child Health and Urologic Sciences, Umberto I Hospital, Sapienza University of Rome, 00161 Rome, ItalyDepartment of Translation and Precision Medicine, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome-Polo Pontino, 00185 Rome, ItalyDuring foetal life, the liver plays the important roles of connection and transient hematopoietic function. Foetal liver cells develop in an environment called a hematopoietic stem cell niche composed of several cell types, where stem cells can proliferate and give rise to mature blood cells. Embryologically, at about the third week of gestation, the liver appears, and it grows rapidly from the fifth to 10th week under WNT/β-Catenin signaling pathway stimulation, which induces hepatic progenitor cells proliferation and differentiation into hepatocytes. Development of new strategies and identification of new cell sources should represent the main aim in liver regenerative medicine and cell therapy. Cells isolated from organs with endodermal origin, like the liver, bile ducts, and pancreas, could be preferable cell sources. Furthermore, stem cells isolated from these organs could be more susceptible to differentiate into mature liver cells after transplantation with respect to stem cells isolated from organs or tissues with a different embryological origin. The foetal liver possesses unique features given the co-existence of cells having endodermal and mesenchymal origin, and it could be highly available source candidate for regenerative medicine in both the liver and pancreas. Taking into account these advantages, the foetal liver can be the highest potential and available cell source for cell therapy regarding liver diseases and diabetes.https://www.mdpi.com/2073-4409/8/8/914foetal liverfoetal organoidsregenerative medicinefoetal liver embryogenesisfoetal stem cells |
| spellingShingle | Antonella Giancotti Marco Monti Lorenzo Nevi Samira Safarikia Valentina D’Ambrosio Roberto Brunelli Cristina Pajno Sara Corno Violante Di Donato Angela Musella Michele Francesco Chiappetta Daniela Bosco Pierluigi Benedetti Panici Domenico Alvaro Vincenzo Cardinale Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine Cells foetal liver foetal organoids regenerative medicine foetal liver embryogenesis foetal stem cells |
| title | Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine |
| title_full | Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine |
| title_fullStr | Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine |
| title_full_unstemmed | Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine |
| title_short | Functions and the Emerging Role of the Foetal Liver into Regenerative Medicine |
| title_sort | functions and the emerging role of the foetal liver into regenerative medicine |
| topic | foetal liver foetal organoids regenerative medicine foetal liver embryogenesis foetal stem cells |
| url | https://www.mdpi.com/2073-4409/8/8/914 |
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